Course summary CNS drugs

Question 1

Antidepressants: names

Answer 1

SSRI: citalopram
SSNRI: duloxetine

Question 2

Antipsychotics (also called neuroleptics); Names

Answer 2

Typical (first-generation): haloperidol
Atypical (second-generation): risperidone

Question 3

Neurodegenerative Disorders; Names

Answer 3

Parkinson: L-DOPA (levodopa)

Question 4

D. Anxiolytics/benzodiazepines names

Answer 4

Benzodiazepines: diazepam

Question 5

E.ADHD names

Answer 5

methylphenidate

Question 6

In what way can we make drugs that can pass through the BBB?

Answer 6

1: Paracellular diffusion, water soluble, can pass through tight junctions

2: Passive diffusion, high lipophilicity and low molecular weight

3: Protein transporters

etc

Question 7

Describe the mechanisms of action of Benzodiazepins

Answer 7

They are a positive allosteric modulator of GABA which means they increase the affinity of GABA and decrease dectivation of the channel. GABA is the primary inhibitory neurotransmitter in the brain. Benzodiazepins modulates the synapses in the limbic system. They induce tolernce and dependance but have a safe profile.

Question 8

Describe the mechanism of action of L-DOPA

Answer 8

Parkinson: L-DOPA (levodopa), is in a class of medications called central nervous system agents. It works by being converted to dopamine in the brain. Carbidopa is in a class of medications called decarboxylase inhibitors. It works by preventing levodopa from being broken down before it reaches the brain.