COVID and Flu tx Flashcards
(13 cards)
What does Tamiflu (Oseltamivir) do for the flu?
Shorten duration of symptoms by 24 hours if started within 48 hours of symptom onset
Prevents serious complications like PNA or hospitalization
Reduce ear infections in children <12
AIs of Tamiflu
Vomitting, headache
Who needs PEP for tamiflu
High risk patients who are unvaccinated during an outbreak
Who needs Post Exposure Prophy for tamiflu
High risk patients
Start within 48 hours of exposure
Continue for 1 week after last exposure if vaccinated, 2 if unvaccinated
When to use tamiflu for suspected influenza
- Severe or progressive, complicated illnesses
- <5 or >65
- Chronic health conditions like asthma, diabetes, CVD, lung disease, kidney and liver disease, cancer
- Pregnancy
Which IV option is available for the flu
Peramivir (Rapivab)
Which kind of an antiviral is tamiflu/peramivir
Neuraminidase inhibitors (active against influenza A and B
What are the COVID treatments
nirmatrelvir-ritonavir (Paxlovid)
Molnuprivair
Remdesivir (IV)
What does nirmatrelvir-ritonavir do
First line treatment for mild to moderate covid with high risk of progression to severe covid
Does not prevent long covid
What DDI’s occur with nirmatrelvir-ritonavir
DO NOT take with: Amioderone, clopidogrel, rivaroxaban
Avoid with: apixaban, atorvostatin, simvastatin, rosuvastatin, lovastatin, salmeterol, codeine
When to use molnupiravir instead of nirmatrelvir-ritonavir
Alternate with high risk progression to severe covid for patients who have DDIs that mean cant use paxlovid
Start within 5 days of sx onset
AIs of molnupriavir
Fetal toxicity– use contraception for 4 days for women and 3 months for men
IV remdesivir indications
hospitalization due to covid
Hypoxia
Alternate with risk of severe progression.
AI: liver injury, hepatitis
