CP 58 - Diseases of MSK Part 2 Flashcards
(6 cards)
1
Q
what are some of the components of muscle fibres
A
basal lamina, plasma membrane, mitochondria , sarcoplasmic reticulum, myofibrils, myonuclei
2
Q
where is dystrophin present?
A
it is the protein portion of the plasma membreane
3
Q
what are some functional systems which are present in the muscles?
A
ion fluxes, neuromuscular transmission, excitation-contraction coupling, oxidative phosphorylation, mRNA transport
4
Q
what are some of the symptoms for muscle diseases?
A
Limited symptoms Wasting Pain Cramping Fasciculations Weakness
5
Q
what are some of the investigations which can be used to investigate muscle disease?
A
clinical exam (neurological) electromyograph - needle inserted into muscles to see electricity conduction nerve conductions studies MRI serum/blood investigations biopsy
6
Q
where are the common sites of biopsy?
A
deltoid, biceps, quadriceps for needle biopsy
