Creutzfeldt-Jakob Disease Flashcards
1
Q
What is a chill way to describe CJD?
A
Most common human prion disease
2
Q
What is CJD?
A
Transmissible prion neurodegenerative proteinopathy
- One of the prion proteins becomes misfolded
- This misfolding then spreads throughout the body
3
Q
Types of CJD?
A
Sporadic
Variant
Iatrogenic
Genetic
4
Q
Describe sporadic CJD?
A
Rapid onset dementia
Neurological signs
Myoclonus
Age of onset- 60s
Very aggressive
5
Q
Describe variant CJD?
A
Painful sensory disturbance
Neuropsychiatric decline
Age of onset is 20s
Duration is 14 months
6
Q
Describe iatrogenic CJD?
A
Cerebellar/visual onset
Multifocal neurological decline
Age of onset - 30s
< 2 years duration
7
Q
Describe genetic CJD?
A
May mimic sCJID Specific subtypes: -GSS: Prolonged ataxic syndrome -FFI: Insomnia ANY AGE
8
Q
EEG in CJD?
A
Characteristic pseudo periodic sharp wave activity
