Crohns

Question 1

Causes

Answer 1

Environmental and genetic
Commoner in certain populations and ashkenazi jews
HLA-DR1 and DQw5 association
Increased risk in smokers

Question 2

Features

Answer 2

Terminal ileum with skip lesions throughout bowel
Commonest in females
Bowel has transmural fissures, ulcers and granulomas. Bowel has cobblestone appearance

Question 3

Complications

Answer 3

Strictures causing intestinal obstruction
Adhesions causing obstruction
Perforation and abscess due to fissures
Anal fistulae, fissures and skin tags
Carcinoma
Bleeding
Malabsorption especially after extensive small bowel resection