CRP

Question 1

Crucial biomarkers for inflammation and infection

Answer 1

C-REACTIVE PROTEIN

Question 2

they are responses provided by immune response if inflammation
or infection is encountered.

Answer 2

Acute-phase reactants/proteins (APRs/APPs)

Question 3

primary inducer for inflammatory
response

Answer 3

Interleukin 1

Question 4

responsible for activating acute-phase
protein

Answer 4

Interleukin 6

Question 5

CRP are synthesized in the

Answer 5

LIVER

Question 6

CRP Normal range:

Answer 6

<10mg/L

Question 7

If the value is greater than 10mg/L, the body is having what?

Answer 7

inflammation or infection.

Question 8

What is the difference between POSITIVE AND NEGATIVE APPs

Answer 8

Negative acute phase protein
“decreases” in inflammation

Positive acute phase protein
“increases” in inflammation

Question 9

more inflammation in the body causes

Answer 9

higher CRP level

Question 9

T OR F
CRP is very specific

Answer 9

F
not specific

Question 10

CRP tests can help monitor ____________ and ___________

Answer 10

disease progress & flares

Question 11

An extremely elevated CRP is suggestive of a possible ___________. (>1000mg/L)

Answer 11

bacterial
infection

Question 12

CRP gene is found on

Answer 12

chromosome 1, short arm

Question 13

CRP has the highest affinity for

Answer 13

─ Phosphocholine on bacteria

─ Mixture of sphingomyelin and phosphatidylcholine in eukaryotic membranes.

Question 14

T or F
CRP can recognize both intrinsic and extrinsic ligands

Answer 14

T

Question 15

3 Functions of CRP

Answer 15

Anti-infective
Anti-inflammatory actions
Scavenging Action

Question 16

Differentiate CRP and ESR based on the following:

Production
Sensitivity
Specificity
Reference range

Answer 16

CRP
rapid, more sensitive, more specific, mg/L

ESR
delayed, moderately sensitive, less specific, mm/h

Question 17

A function of CRP the is characterized by binding avidly to cell that are undergoing apoptosis or necrosis.

Answer 17

Scavenging Action

Question 18

PROCESSES INDUCED BY CRP

OPERA V

Answer 18

Activation of complement cascade
RAAS activation
Vascular wall damage
Prothrombotic state
Endothelial dysfunction
Opsonization of oxidized LDL

Question 19

FACTORS AFFECTING CRP LEVELS

Answer 19

Gender
Body mass effect
Ethnicity
Exercise
Alcohol consumption

Question 20

T or F
Women have higher CRP levels than men

Answer 20

T

Question 21

T or F
The higher the weight, the lower level of CRP

Answer 21

F
the higher

Question 22

T or F
After exercise CRP levels decrease

Answer 22

T

Question 23

METHODS FOR DETECTION OF CRP

(VIRE)

Answer 23

Visual agglutination
Immunoturbidimetry
Rapid immunodiffusion
ELISA

Question 24

Utilizes antigen-antibody interaction on a solid surface

Answer 24

ELISA

Question 25

Relies on the formation of antigen-antibody complexes causing turbidity

Answer 25

Immunoturbidimetry

Question 26

Based on immunoprecipitation, where CRP diffuses towards specific antibodies in a gel medium, forming visible precipitin bands

Answer 26

Rapid immunodiffusion

Question 27

Involves the clumping of latex particles coated with CRP specific antibodies

Answer 27

Visual agglutination

Question 28

- Osteoarthritis - Predictive coronary events (esp. in stable angina) - Proinflammatory or prothrombotic effects

Answer 28

Elevated CRP levels

Question 29

- SLE - Scleroderma - Sjogren Syndrome - Dermatomyositis/ Polymyositis

Answer 29

Mild elevation of CRP levels

Question 30

- Helpful tool in determining the response to antibiotic therapy and duration of treatment

Answer 30

Normalization of CRP levels

Question 31

- Elevated levels were seen in majority of kidney or heart transplant - Highly elevated GVHD

Answer 31

Transplant

Question 32

- An increase is associated with a poorer short term prognosis

Answer 32

Cerebral vein or sinus thrombosis

Question 33

________ with platelet counts (>400,000/uL) and CRP levels (>2.45 mg/dl) have been found to be the strongest laboratory predictors of positive temporal artery biopsy

Answer 33

Thrombocystosis

Question 34

- Level peaks 3 days after onset of pain - Level of 150 mg/L distinguishes mild from sever disease

Answer 34

Pancreatitis

Question 35

More sensitive than CRP especially for cardiovascular injury

Answer 35

HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP)

Question 36

HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) NORMAL RANGE

Answer 36

Normal range: <0.3 mg/dl

Question 37

USES OF HS-CRP

Answer 37

1. Performing risk assessment for cardiovascular disease 2. Determine risk of hypotension

Question 38

these are pathogenic possibilities or risk factors

Answer 38

extrinsic ligands

Question 39

these are certain molecules that are normally found inside the body

Answer 39

intrinsic/self-ligands