CSF

Question 1

Normal CSF protein

Answer 1

15-45 mg/dl
* protein is filtered out

Question 2

Elevated CSF protein indicates

Answer 2

Meningitis

Question 3

Normal Glucose in CSF

Answer 3

60% to 70% of plasma concentration

• blood collection should be done 2 hours before the spinal tap. Plasma glucose must be run simultaneously*

Question 4

Normal CSF lactate

Answer 4

10 to 24 mg/dL

Question 5

For monitoring of antibiotic treatment in CSF

Answer 5

CSF lactate

Question 6

Normal Glutamine in CSF

Answer 6

8 to 18 mg/dl

associated with liver disorders

Question 7

Gold standard for ID of Meningitis

Answer 7

Culture

Question 8

Acid Fast Staining in CSF is for

Answer 8

Tuberculosis meningitis

Question 9

India Ink in CSF

Answer 9

For Cryptococcus

Question 10

More sensitive and highly specific test for CSF (potential use in urine and whole blood)
Use before symptom onset

Answer 10

Antigen Detection

Question 11

CSF Testing:
* marked elevation in protein
* marked decrease in glucose
* >35mg/dL lactate
* WBC: elevated neutrophils

Answer 11

Bacterial Infection

Question 12

Limulus lysate Test

Answer 12

Detect endotoxin (specific for bacteria that produce endotoxin)

Question 13

Volume of CSF produced per hour

Answer 13

20 mL

Question 14

Total CSF volume

Answer 14

Adults: 90 - 150 mL
Neonates: 10 - 60 mL

Question 15

At what level does the spinal cord end? At what level should CSF be collected?

Answer 15

Lower border of L

.CSF is collected between L3-L4 or L4-L5. The interspace between L4-L5 is at the level of the iliac crest