CSO Meds, Supps, Fxn Foods, Cultures Flashcards
(40 cards)
CYP3A4
Inducer = St. John’s wort
Inhibitor = grapefruit juice
Busulfan
Avoid aspirin-containing OTC medications
Xeloda / Capecitabine
Caution with warfarin
Vitamin B6 – may help prevent/reduce hand-foot syndrome
Cetuximab / Erbitux
Watch Mg and Ca closely!
Cisplatin / Platinol
HYDRATION! to prevent renal toxicity
Watch RENAL fxn and lytes (mg, ca, na, K+)
Cyclophosphamide / Cytoxan
HYDRATION! Educate pts to empty bladder every 2-3 hours during night
Increases the effect of anti-coagulants
Dasatinib
Avoid CYP3A4 inducers and inhibitors
Erlotinib
Avoid CYP3A4 inducers and inhibitors
Flurouracil / 5-FU / Adrucil
Only IV bolus infusions
Melt ICE CHIPS in mouth 10-15 min before and after = to prevent oral mucositis
Vit B6 may help reduce hand-foot syndrome
Imatinib / Gleevac
Avoid CYP3A4 inducers and inhibitors
Melphalan
Premedicate with antinausea 1 hour before oral dose
Small frequent meals
Methotrexate
- *Avoid folic acid** and it’s derivatives during methotrexate drug therapy
- *Avoid ETOH** = increases liver toxicity.
Procarbazine / Hydrochloride / Mutalane
- *Low Tyramine** diet during and 2 weeks after = Tyramine can cause HTN or intracranial hemorrhage
- *Avoid ETOH**
Tamoxifen / Nolvadex
Avoid antacids within 2 hours
Avoid CYP3A4 inducers and inhibitors
Thalidomide / Thalomid
Avoid barbiturates and ETOH
Vinblastine / Velban / Vincristine
Avoid CYP3A4 inducers and inhibitors
Can cause constipation = may need stool softeners / laxatives
Zometa / Zoledronic Acid
Calcium 500 mg and Vitamin D 400 IU
Aloe
May cause diarrhea. May be useful for constipation.
Aloe may delay radiation dermatitis in H&N patients.
Alpha -lipoic acid
Antioxidant important for energy production that is naturally synthesized in the body.
May improve insulin sensitivity, reduce neuropathic symptoms and triglycerides and improve QOL.
Examples: Spinach, broccoli, brewer’s yeast
Black Cohosh
Supresses symptoms (eg. HOT FLASHES) associated with menopause and cancer treatment
Insufficient evidence to support the use of black cohosh in cancer treatments.
Coenzyme Q10
Antioxidant
May reduce renal toxiticity and cardiotoxicity of doxyrubicin.
May have pro-coagulant effects. Can influence efficacy of warfarin. And thus, CONTRAIDICATED IN PATIENTS WHO TAKE WARFARIN!
Curcumin
Found in tumeric
Inhibits proliferation of breast cancer cells.
May act to enhance apoptosis.
Enchances anticancer effects of 5-FU and the combination of 5-FU and cisplatin.
Some are combined with piperine (black pepper spice) to improve absorption.
Flaxseed
Source of Alpha-Linolenic Acid (Omega-3 fatty acid). Rich in lignans
Soluble and insoluble fibers
Has phytoestrogenic and antioxidant properties. May enhance effects of Tamoxifen.
May affect absorption of some drugs. Medications should be taken 1-2 hours before or after consuming flaxseed.
May help reduce tumor growth in breast cancer
May help lower PSA and slow growth of prostate cancer cells.
Garlic
May stimulate apoptosis.
Shows potential as anticancer treatments, however insufficient evidence.
May interfere with activity of some meds, particularly ANTICOAGULANT DRUGS.