CT 2 - Depression And Mood Disorders Flashcards
(43 cards)
What are the main symptoms of depression
Persistent low mood (for at least 2 weeks)
Anhedonia (lack of interest or pleasure)
Anergia (lack of energy and fatigue to do anything)
Others include:
Sleep disruption
Lowered self esteem
Lack of appetite
Feelings of guilt
Poor concentration
Suicidal ideation and self harm
Maybe an episode or if recurrent then coined as unipolar depressive disorder
What are the risk factors for suicide
FHX of mental health problems
Previous suicide attempt
Severity of depression
Anxiety and feelings of hopelessness
Personality disorders
Alcohol abuse
Being male
What are the risks factors for developing depression
Heritability
W>M
ACEs
Personality (neuroticism)
Lack of social support + lonely
Physical illness
Give examples of SSRIs
Sertraline (first line for adults)
Citalopram
Fluoxetine (first line for children and teens)
Paroxetine
Take 2-4 weeks to work.
* be careful as increase suicidal ideation especially in younger people.
Increase risk of bleeding and can cause hyponatremia
Which SSRI has a longer Half life and greater drug interactions
Fluoxetine
Citalopram increases QT interval
What are the side effects of SSRIs
D +V
Agitation and restlessness
Increase risk of GI bleeding
Drowsiness
Sexual dysfunction eg impotence
What is serotonin syndrome
Symptoms caused by excessive serotonin:
Hypertension
Hyperthermia
Tachycardia
Hyperreflexia
Increased tone
Which combinations of drugs can result in serotonin syndrome
Triptans (migraine med) + SSRI
St John’s wort + SSRI
Tramadol + SSRI
MAOI’s + SSRI
Examples of TCA’s
Amitriptyline
Clomipramine
Amoxapine
TCA overload causes prolonged QT
Side effects of TCAs
Blurred vision
Dry mouth
Constipation
Rash
Examples of monoamine NT’s
Serotonin
Dopamine
NA
Adrenaline
How do MAOI’s work and what are they used for
They block an enzyme (monoamine oxidase) which breaks down the monoamines. Results in increased levels in synapse.
Used for panic disorders and social phobia
How do MAOI’s work and what are they used for
They block an enzyme (monoamine oxidase) which breaks down the monoamines. Results in increased levels in synapse.
Used for panic disorders and social phobia
Examples of MAOI’s
Rasagiline
Selegiline
Hydrazine
Phenelzine
What other drug can be used for major depression that is not included in the normal classes of anti-depressants
Mirtazapine (A2 receptor antagonist)
Examples of SNRIs
Venlafaxine
Duloxetine
Uses for SNRIs
Major depressive disorder
Anxiety disorder
OCD
ADHD
Neuropathic pain +fibromyalgia
What are the side effects associated with SNRIs
Same as SSRIs
Increased risk of hypertension but milder sexual dysfunction
Examples of mood stabilisers
1) anti-convulsants like Sodium valproate, lamotrigine, carbamazepine (SE include teratogenic, weight changes and lamotrigine can cause a rash (Steven’s Johnson syndrome)
2) Lithium (gold standard. Can cause kidney failure, nephrogenic diabetes insipidus and hypothyroidism)
3) anti-psychotics can also be used as mood stabilisers
What are the side effects of MAOI;s
Cheese reaction: fatal hypertensive crisis = tyramine found in common foods like can interact with drug to cause excess release of NA leading to severe vasoconstriction leading to high blood pressure
Which drug is reserved for treatment resistant schizophrenia
Clozapine
Which anti-psychotics are prolactin sparing or may even lower prolactin levels
Clozapine
Aripiprazole
What are symptoms of hyperprolactinemia
Irregular periods
Weight gain***
Infertility
Loss of libido
Galactorrhoea
Gynaecomastia
Can be treated with adding aripiprazole or a dopamine agonist such as bromocriptine or cabergoline
as a result of typical anti-psychotics Low levels of dopamine in which pathway leads to extrapyramidal symptoms
Nigrostriatal pathway