Current Topics in Gynecology

Question 1

STEM CELLS AND THERAPIES IN GYNECOLOGY

Answer 1

stem cells (progenitor cells). Stem cells have the potential to be used in the field of regenerative medicine

Question 2

Use of Stem Cells

Answer 2

Treatment of
inherited genetic disorders.
hematological diseases.

Question 3

Properties of Stem Cells

Answer 3

undergoing numerous cell divisions maintaining the undifferentiated state.

Multipotency: Capacity to differentiate into a mature cell type.

Question 4

Totipotent Stem Cells

Answer 4

• Totipotent Stem Cells are from the morula can differentiate into embryonic and extraembryonic cell types. • Totipotent cells can produce a complete and viable organism.

Question 6

Pleuripotent Stem Cells

Answer 6

Descendent of totipotent cells. These cells can differentiate on tissues derived from any of the three germ layers
including fetal tissues (placenta, umbilical cord, amnion, amniotic fluid cells).

Question 7

Embryonic Stell Cells

Answer 7

Embryonic Stell Cells are pluripotent. These cells are derived from the inner cell mass of a blastocyst.

Question 8

Multipotent Stem Cells

Answer 8

differentiate into various tissues originating from a single germ layer
(mesenchymal cells or hemopoietic stem cells that produce RBC WBC platelets).

Question 9

Unipotent cells produce

Answer 9

Only their own cell type.
They have greater self-renewal property than fully mature cells.

Question 10

Embryonic Stem (ES)

Answer 10

Cells have the potentials to be used in regenerative medicine

Question 11

Multipotent Stem Cells

Answer 11

can be obtained from several fetal tissues (following medical termination of pregnancy or at birth).

Question 12

USE OF EMBRYONIC STEM (ES) CELLS IN REGENERATIVE MEDICINE

Answer 12

• Regeneration of urogenital tract tissues
• Biomaterial
• mullerian duct reconstruction

Question 13

Regeneration of urogenital tract tissues ?

Answer 13

• Treatment of stress urinary incontinence (SUI)
(when pressure on the bladder from physical activity or movement causes urine to leak)
- Regenerate urinary sphinter

• Bladder reconstruction
- Regenration of bladder walls

Question 14

Biomaterials? Used?

Answer 14

generate new muscles/tissues which can perform in an integrated manner with the existing tissues to provide mechanical support to the pelvic organs.

Used in
pelvic organ prolapse (POP) urinary incontinence

Question 15

Müllerian ducts reconstruction?

Answer 15

Progenitor cells can be used for uterine malformations.

Autologous cells (from vaginal biopsy) can be expanded and functional vagina can be reconstructed for a woman with vaginal agenesis.