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CV 1 - Martin Pharm > CV ANS Drugs > Flashcards

CV ANS Drugs Flashcards

(50 cards)

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1
Q

Norepinephrine

A

a1=a2, B1»B2, Sympathomimetic (Agonist)

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2
Q

Epinephrine

A

a1=a2, B1=B2, Sympathomimetic (Agonist)

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3
Q

Isoproterenol

A

B1=B2»»a, Sympathomimetic (Agonist)

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4
Q

Phenylephrine

A

a1>a2»»>B, a-selective agonist, Sympathomimetic (Agonist)

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5
Q

Albuterol

A

B2»B1»»a, B2-selective agonist, Sympathomimetic (Agonist)

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6
Q

Dopamine

A

D1=D2»B»a, Dopamine agonist, Sympathomimetic (Agonist)

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7
Q

Propranolol

A

B1+B2»>a, Nonselective B-Adrenergic Antagonist

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8
Q

Atenolol

A

B1»B2, B1-Selective B-Adrenergic Antagonist

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9
Q

Metoprolol

A

B1»B2, B1-Selective B-Adrenergic Antagonist

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10
Q

Phentolamine

A

a1=a2, Nonselective a-Adrenergic Antagonist

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11
Q

Prazosin

A

a1»»a2, a1-Selective a-Adrenergic Antagonist

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12
Q

Carvedilol

A

B1=B2>=a1>a2, Mixed Antagonist

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13
Q

Acetylcholine

A

Muscarinic and Nicotinic Agonist (Muscarinic Cholinergic Agonist) - very short acting

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14
Q

Bethanechol

A

M1-5»»Nm,Nn (Muscarinic Cholinergic Agonist)

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15
Q

Methacholine

A

M1-5»Nm,Nn (Muscarinic Cholinergic Agonist)

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16
Q

Atropine (Oral, Parenteral, Ophthalmic)

A

M1=M2=M3»»Nm,Nn (Muscarinic Receptor Antagonist)

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17
Q

Ipratropium (Inhalation only)

A

(Muscarinic Receptor Antagonist)

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18
Q

Tiotropium (Inhalation only)

A

(Muscarinic Receptor Antagonist)

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19
Q

Parasympathetic Endings

A

Cardiac and smooth muscle, gland cells, nerve terminals

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20
Q

Sympathetic Endings

A

Sweat glands, cardiac and smooth muscle, gland cells, nerve terminals, renal vascular smooth muscle

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21
Q

Cholinergic Nerves (ACh)

Study These Flashcards
A

All Preganglionic to all ganglia, Post para, Post symp to sweat glands, Somatic muscle

22
Q

Adrenergic Nerves (NE)

Study These Flashcards
A

Post symp to cardiac and smooth muscle, and gland cells (effector junctions)

23
Q

Adrenal Medulla

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A

Symp leads to release of NE and E into circulation

24
Q

G Protein receptors

Study These Flashcards
A

All adrenergic, All M Cholinergic - signal cascade

25
Catecholamines
(5) Epinephrine, Norepinephrine, Isoproterenol, Dopamine, Dobutamine - metabolize quickly, not effective orally, do not penetrate CNS easily
26
Dobutamine
B1>B2>>a, B1-Selective Agonist, Sympathomimetic (Agonist)
27
Non-catecholamines
Phenylephrine, Albuterol
28
Alpha Adrenergic effects
Constrict blood vessels (a1>a2)
29
Beta Adrenergic effects - B1
Inotropic (strengthen contraction) and chronotropic (increase rate)
30
Beta Adrenergic effects - B2
Relax bronchioles and relax certain blood vessels
31
Epinephrine as Prototype (a and B agonist) on HEART and Vessels
Increase heart rate, increase force of contraction, increase signal conduction, increase O2 consumption, increase work of heart. Coronary vessel dilate and other constrict.
32
Epinephrin reversal
Low dose activates B2 and causes vessel relaxation, high does activate a1 causing vessel constriction
33
Epinephrine on BP (low dose - high dose behave like NE)
Systole increase and Diastole slight decrease, mean is same
34
Epinephrine on smooth muscle
Bronchiole relaxation
35
Epinephrine clinically
Pediatric Asthma (bronchodilater, vasoconstricter, inhibit histamine release via B2); anaphylactic shock
36
Norepinephrine on Heart and Vessels
Positive inotropic (direct,) negative chronotropic (indirect,) vasoconstrict and increase BP
37
Isoproterenol on Heart and Vessels
Increased HR and Force of contraction, vasodilate (increase systole and decrease diastole with overall decrease,) relax bronchioles
38
Dopamine on kidneys
Vasodilate renal vascular beds
39
Dobutamine effectiveness
Less than NE
40
Phenylephrine on Vessels
Vasoconstriction, reflex bradycardia
41
Phentolamine on Vessels
Decrease BP, reflex tachycardia
42
Prazosin on Vessels
Decrease BP, less reflex tachycardia
43
Propranolol Effects (Beta Blocker)
Decrease HR and CO, decrease conduction, decrease exercise tolerance, decrease depol, blocks dilation of vessels and blocks bronchodilation, decrease lipolysis and glycogenolysis
44
Propranolol Clinical Uses
Angina (decrease CO and O2 demands,) HTN, Arrhythmias, post MI
45
Atenolol
Blocks B1 WAY more than B2
46
Muscarinic effects
Decrease spontaneous depol (neg chronotropy,) decrease conduction velocity, decrease atrial contractile strength, dilate vessels, contract bronchioles
47
Muscarinic block
Atropine
48
Ipratroprium
Can't be absorbed across membranes, used for COPD
49
Atropine Effects
Tachycardia, bronchodilation/relaxation
50
Clinical Use of Antimuscarinics
Reverse reflex bradycardia

CV 1 - Martin Pharm (1 decks)

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