CV Drugs Flashcards

(99 cards)

1
Q

Diuretics MOA `

A

Alter excretion or reabsorption of electrolytes in kidney

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2
Q

Diuretics uses

A

edema with HF, cirrhosis, estrogen therapy; hypertension, renal disease, cerebral edema, glaucoma, seizures

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3
Q

Diuretics SE

A

dizzy, headache, orthostatic hypotension, electrolyte imbalance, glycosuria, anorexia

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4
Q

Diuretics CI

A

electrolyte imbalance, severe kidney/liver disease, anuria

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5
Q

Diuretics caution

A

renal dysfunction, preg/lact

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6
Q

Diuretics interact

A

primidone, cisplatin, aminoglycoside, anticoagulants, NSAID, salicylates, hydantoins, ACE inhibitors, allopurinol, anesthetics

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7
Q

Loop diuretics ex

A

bumetanide, ethacrynic acid, furosemide, torsemide

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8
Q

K-sparing diuretics ex

A

amiloride, spironolactone, triamterene

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9
Q

Thiazide diuretics ex

A

-thiazide, chlorthalidone, indipamide, metolazone

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10
Q

carbonic anhydrase inhibitors (diuretics) ex

A

acetazolamide, methazolamide

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11
Q

osmotic diuretics ex

A

glycerin, isosorbide, mannitol, urea

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12
Q

statins uses

A

hyperlipidemia, primary prevention of coronary events, secondary prevention of cv events

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13
Q

statins SE

A

headache, dizzy, insomnia, memory impairment, flatulence, abdominal pain, hyperglycemia

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14
Q

statins CI

A

preg/lact

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15
Q

statins cautions

A

alcoholism, acute infection, hypotension, trauma, endocrine disorder, visual disturbance, myopathy

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16
Q

statins interact

A

macrolides, amiodarone, niacin, protease inhibitor, verapamil, warfarin

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17
Q

PCSK9 inhibitors ex

A

alirocumab, evolocumab (new drugs)

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18
Q

Bile acid resins uses

A

hyperlipidemia, gallstone dissolution, pruritus with partial biliary obstruction

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19
Q

bile acid resins SE

A

constipation, increased bleeding tendencies

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20
Q

bile acid resins CI

A

complete biliary obstruction

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21
Q

bile acid resins precautions

A

diabetes, peptic ulcer, preg/lact

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22
Q

bile acid resins interact

A

anticoagulants, thyroid hormone, vitamins KADE

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23
Q

bile acid resins ex

A

cholestyramine, colestipol, colesevelam

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24
Q

fibrates ex

A

fenofibrate, gemfibrozil

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25
fibrates use
hyperlipidemia
26
fibrates SE
gallbladder stones, inflammation of gallbladder
27
fibrates CI
severe renal/hepatic disease, primary biliary cirrhosis
28
fibrates precautions
preg/lact
29
fibrates interact
anticoagulants, cyclosporine, statins, sulfonylureas
30
niacin/ezetimibe use
adjunct antihyperlipidemics
31
niacin/ezetimibe SE
abdominal pain, flushing, itching
32
niacin/ezetimibe CI
peptic ulcer, hepatic dysfunction, arterial bleeding
33
niacin/ezetimibe precautions
renal disease, alcohol, angina, gout, preg/lact
34
antihypertensive types
diuretics, beta blockers, anti adrenergics, CCBs, ACE inhibitors, ARBs, vasodilators
35
antihypertensive antiadrenergics ex
clonidine, methyldopa, doxazosin, prazosin
36
CCBs ex
-dipine, verapmil, dilitiazem
37
ACE inhibitors ex
-pril
38
ARBs ex
-sartan
39
antihypertensive vasodilators ex
hydralazine, minoxidil
40
antihypertensives SE `
dizzy, URI, cough, abdominal pain, anorexia, constipation, rash, tachycardia, hypotension, proteinuria, neutropenia
41
ACE inhibitors uses
hypertension, heart failure
42
ACE inhibitors CI
renal disease, salt/volume depletion, bilateral stenosis, angioedema, preg/lact
43
ACE inhibitors precautions
diuretics, sodium depletion, hypovolemia, coronary/cerebrovascular insufficiency, dialysis
44
ARBs CI
renal disease, salt/volume depletion, bilateral stenosis, angioedema, preg/lact
45
ARBs uses
hypertension, heart failure
46
ARBs precautions
hypovolemia, diuretics
47
Beta blockers uses
hypertension, heart failure
48
CCBs uses
hypertension, angina
49
CCBs precautions
HF, preg/lact
50
CCBs interact
cimetidine, ranitidine, theophylline, digoxin, rifampin
51
CCBs SE
no serious ones
52
ARBs interact
fluconazole, indomethacin
53
ACE inhibitors interact
NSAID, rifampin, allopurinol, digoxin, loop diuretics, lithium, hypoglycemics, potassium-sparing diuretics
54
Nitrates MOA
vasodilation
55
nitrates uses
treat, prevent, and relieve pain from angina
56
nitrates SE
headache, dizzy, restless, rash, flushing, hypotension
57
nitrates CI
severe anemia, closed-angle glaucoma, postural hypertension, MI, head trauma, cerebral hemorrhage, constrictive pericarditis
58
nitrates precautions
severe head trauma, hypothyroidism, preg/lact
59
nitrates interact
aspirin, CCBs, dihydroergotamine, heparin, phosphodiesterase inhibitors, alcohol
60
nitrates ex
isosorbide, nitroglycerin
61
Misc antianginal drugs
ivabradine, ranolazine
62
anticoagulants ex
warfarin, heparin
63
anticoagulants uses
preventing and treating DVT, atrial fibrillation with clots, PE, treating MI, preventing clots in surgery
64
anticoagulants SE
abdominal pain, alopecia, rash, hepatitis, jaundice, thrombocytopenia, blood dyscrasias
65
anticoagulants CI
active bleeding, hemorrhagic disease, TB, leukemia, hypotension, GI ulcers, recent eye or CNS surgery, aneurysm, severe renal/hepatic disease, preg/lact
66
anticoagulants precautions
fever, HF, diarrhea, diabetes, malignancy, hypertension, psychoses, depression
67
anticoagulants interact
NSAIDs, aspirin, acetaminophen, penicillin, GNATs, isoniazid, tetracycline, cephalosporins, beta blockers, loop diuretics, disulfiram, cimetidine, contraceptives, barbiturates, diuretics
68
antiplatelets MOA
decrease platelet aggregation
69
antiplatelets uses
people at risk for acute coronary syndrome, MI, stroke, intermittent claudication
70
antiplatelets SE
palpitations, bleeding, dizzy, headache, constipation, dyspepsia
71
antiplatelets CI
preg/lact, CHF, active bleeding, TTP
72
antiplatelets precautions
elderly, pancytopenia
73
antiplatelets interactions
aspirin, NSAID, macrolides, digoxin, phenytoin
74
antiplatelets ex
abciximab, anagrelide, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticagrelor, ticolpidine, tirofiban, vorapaxar
75
thrombolytics ex
alteplase, tenecteplase, reteplase
76
thrombolytics MOA
break down existing fibrin clots
77
thrombolytics uses
acute stroke or MI by lysis of blood clots in coronary arteries, PE, DVT, occlusion in central venous catheters
78
thrombolytics SE
bleeding (internal or external)
79
thrombolytics CI
active bleeding, stroke history, aneurysm, recent intracranial surgery
80
thrombolytics precautions
recent major surgeries, recent stroke, trauma, labor, GI bleeding, hypertension, diabetic retinopathy, anticoagulants
81
thrombolytics interactions
aspirin, dipyridamole, anticoagulants
82
Cardiotonics ex
digoxin, ivabradine, milrinone
83
cardiotonics MOA
positive inotropic activity
84
cardiotonics uses
heart failure, atrial fibrillation
85
cardiotonics SE
headache, weakness, drowsy, visual disturbance, arrhythmia, anorexia
86
cardiotonics CI
ventricular failure, ventricular tachycardia, cardiac tamponade, restrictive cardiomyopathy, AV block
87
cardiotonics precautions
electrolyte imbalance, thyroid disorder, severe carditis, heart block, MI, severe pulmonary disease, acute glomerulonephritis, preg/lact
88
cardiotonics interactions
thyroid hormones, loop/thiazide diuretics, amiodarone, benzodiazepines, indomethacin, itraconazole, macrolides, propafenone, quinidine, spironolactone, tetracycline, verapamil, aminoglycosides, antacids, antineoplastics, charcoal, cholestyramine, colestipol, neomycin, rifampin
89
class 1 antiarrhythmics ex
Na channel blockers: disopyramide, flecainide, lidocaine, mexiletine, propafenone, quinidine
90
class 2 antiarrhythmics ex
beta blockers: acebutolol, propanolol
91
class 3 antiarrhythmics ex
K channel blockers: amiodarone, dofetilide, dronedarone, ibutilide, sotalol
92
class 4 antiarrhythmics ex
CCBs: verapamil
93
class 5 antiarrhythmics ex
misc: adenosine, digoxin, magnesium sulfate
94
antiarrhythmics MOA
treat conduction problems
95
antiarrhythmics uses
PVCs, ventricular tachycardia, PACs, paroxysmal atrial tachycardia, Atrial fibrillation or flutter, tachycardia when you want rapid, short term control
96
antiarrhythmics SE
weak/lightheaded, somnolence, hypotension, arrhythmia, bradycardia, urinary retention, inflammation
97
antiarrhythmics CI
preg/lact, 2nd/3rd degree AV block, severe HF, aortic stenosis, hypotension, cardiogenic shock, myasthenia gravis, lupus
98
antiarrhythmics precautions
electrolyte disturbance, HF
99
antiarrhythmics interactions
grapefruit