CV Risk Flashcards
(30 cards)
What is dyslipidemia
increase in total cholesterol, LDL, TG or decrease in HDL
—- abnormalities in lipoprotein can cause predisposition to coronary, cerebrovascular + PVA + major risk factor for CHD
How is dyslipidemia diagnosed
no specific cholesterol level (LDL level)
—- risk of CHD/CVD risk is the basis of diagnosis
What is CV risk
prob that a pt is going to experience an outcome (whatever the calculator looks at) in defined time period based on her traits
If Y value is continuous such as incidence rate…, what type of regression should you use?
multiple linear regression model
If Y is categorical (yes or no — death), what type of regression should you use
logistic
If Y is time to event (survival data), what type of regression should you use
— ex// time to HA
COX regression (proportional hazard regression)
What are some of the main variables used in risk calculation
age, gender, total cholesterol, HDL, SBP, DM smoking
others: BP treatment, family history, BMI, waist, geographic location, CKD, Afib
What variables does FRS not include
Didn’t include FH of CVD
— variables considered: age/gender/ethnicity/ total cholesterol, HDL, SBP , smoking, DM + BP treatment
What outcomes does the FRS assess risk of
hard + soft outcomes (HA, stroke, angina, HF + intermittent claudications)
What variables does the QRISK2 calculator not include
DM
variables included: age/gender/ethnicity, total cholesterol, HDL, SBP, BP treatment , smoking, FH of CVD, BMI
What outcomes does the QRISK2 calculator determine risk of
hard outcomes —— HA + stroke
What variables are not included/accounted for in ASCVD calculator
FH of CVD
Variables included: age/gender/ethnicity, total cholesterol, HDL, SBP, BP treatment, smoking + DM
What outcomes does the ASCVD calculator determine risk of
CHD death, MI + strokes
T or F: the FRS normally overestimates risk
T
Which risk calculator is the most validated
FRS
Which pop can we apply the FRS calculator to (age group) + traits
those 40-79 w/out CVD (primary )
—— if have CVD — already high risk
How often should you repeat risk calculation
every 5 years or when major changes
Negatives of the ACC/AHA calculator
- only looked at hard outcomes (stroke, CHD, MI)
- doesn’t looked at FH
— DM included in calculation but only as a yes/no (not severity, duration, type)
—- overestimates by 50%
What does the Score calculator tell us
vascular age of person’s arteries
—- look at BP + smoking history to get age of arteries
Which demographics were used for FRS
white middle aged men + women
Advantages of FRS
widely used in NA — showed to be reliable
- validation studies done
- calibration done to show application to different populations
What is considered a low risk FRS score
< 10%
What is considered an intermediate FRS risk
10-20%
What is considered high risk FRS score
> 20%
