CVD 2 Flashcards
(150 cards)
1
Q
This is a segmental, nonatheromatous, noninflammatory
arterial disease of unknown etiology, almost exclusively
in women
A
Fibro m u scu l a r Dysplasia
2
Q
Arteries involved in FMD
A
internal carotid artery is involved most frequently,
followed by the vertebral and cerebral arteries
3
Q
Histology of FMD
A
The narrowed arterial segments show degeneration
of elastic tissue and irregular arrays of fibrous and
smooth muscle tissue in a mucous ground substance
4
Q
Mechanisms of ischemia in FMD
A
from thrombi in the pouches or in relation to intraluminal septa
5
Q
In pts with FMD, between 7 and 20 percent of affected individuals are found to have intracranial
_________ (rarely a giant aneurysm),
A
saccular aneurysms
6
Q
the process formerly
known as Erdheim’ s medionecrosis aortica cystica
A
I nte r n a l Ca rot i d Artery D i ssect i o n
7
Q
The frequency of cerebral stroke with aortic dissection
has varied from ______ percent and that of spinal
stroke has been approximately ______ percent
A
10 to 50
10
8
Q
___________are also associated with an increased risk of vascular dissection
A
The Ehlers-Danlos and Marfan syndromes,
osteogenesis imperfecta,
Loeys-Dietz syndrome (transforming growth factor [TGF]-,B receptor mutation), and alpha1 -antitrypsin deficiency
9
Q
In most cases, dissection of the internal carotid artery
can be detected by ultrasonography and confirmed by
MRl and CTA, which show a _____
A
double lumen
10
Q
In pts with Carotid artery dissection,
angiography usually reveals an elongated, but variable
length, irregular narrow column of dye, usually
begiruting 1 .5 to 3 em above the carotid bifurcation and
extending to the base of the skull, a picture that Fisher
has called the ________
A
string sign
11
Q
Rapid
and extreme rotational movement of the neck is the most
common identifiable cause of ____________
A
vertebral artery dissection
12
Q
Another interesting but rare
association with dissection has been the ________
A
reversible cerebral vasoconstriction syndrome
13
Q
___________percent of patients
with the angiographic signs of cervical artery dissection;
mainly, these were patients who had fluctuating
ischemic symptoms but without stroke have a complete or excellent recovery
A
85%
14
Q
Tx of cervical artery dissection
A
anticoagulation for several weeks
or months and followed up with some form of arteriography.
15
Q
relative CI to anticoagulation in pts with cervical artery dissection
A
there is existing
subarachnoid blood on a CT scan or if there is a pseudoaneurysm
within the intracranial portion of the dissection
16
Q
refer to an extensive basal
cerebral rete mirabile-a network of small anastomotic
vessels at the base of the brain around and distal to the
circle of Willis,
A
Moya-Moya
17
Q
Associations of Moya-Moya dse
A
segmental stenosis or occlusion of the terminal intracranial parts of both internal carotid arteries
18
Q
Certain hemoglobinopathies, particularly sickle cell anemia, may cause a vasoocculsive condition equivalent to moyamoya disease, possibly because of sickling of red blood cells in the vasa vasorum of the_______
A
supraclinoid carotid artery.
19
Q
MC initial presentation of Moya Moya in adults
A
subarachnoid hemorrhage was the most common initial
manifestation.
20
Q
in pts with Moya Moya, EEG phenomenon in which high-voltage slow waves reappear 5 min after the end of hyperventilation is called?
A
rebuild up
21
Q
Histology of pts with Moya Moya
A
The adventitia, media, and internal
elastic laminae of the stenotic or occluded arteries were
normal, but the intima was greatly thickened by fibrous
tissue
22
Q
Theories on the origin of the rete mirabile
A
congenital vascular malformation (i.e., a
persistence of the embryonal network) or a rich collateral
vascularization secondary to a congenital hypoplasia,
acquired stenosis, or occlusion of the internal carotid
arteries early in life.
23
Q
Tx of Moya Moya
A
transplantation of a vascular muscle flap,
omentum, or pedicle containing the superficial temporal
artery to the pial surface of the frontal lobe temporal pial
synangiosis with the idea of creating neovascularization
of the cortical convexity
24
Q
The term has come to denote a widespread degeneration of cerebral white matter having a vascular causation and observed in the context of hypertension, atherosclerosis of the small blood vessels, and multiple strokes.
A
Binswanger Disease
25
Imaging feature of Binswanger
leukoaraiosis describes the imaging appearance
of hypointense periventricular tissues, presumably
damaged by chronic ischemia
26
Clinical features of Binswanger
Dementia, a pseudobulbar state, and a gait disorder,
alone or in combination, are the main features of
Binswanger cases
27
A process with an imaging appearance of large confluent
cerebral white matter changes, somewhat similar to
Binswanger leukoencephalopathy, has been identified
as an autosomal dominant familial trait linked in several
families to a missense mutation on chromosome 19.
Fa m i l i a l Su bcortica l I nfarction
| CADASI L a n d CARAS I L
28
A syndrome of early alopecia and lumbar spondylosis
with the white matter changes typical of CADASIL has
been identified as a recessively inherited disease _______________
(cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy [CARASIL])
29
Mutation associated with Binswanger
missense change on
chromosome 19 of the NOTCH 3 gene, in the same locus
as the gene for familial hemiplegic migraine
30
Biopsy of Binswanger disease
eosinophilic inclusions in the arterioles of a skill
| biopsy
31
Mutation associated with CARASIL
HTAR1 gene
32
Result of HTAR1 gene mutation
fragmentation and duplication of the internal elastic
| lamina of cerebral vessels with narrowing of their lumens
33
MC cause of inherited deficiencies of naturally
| occurring anticoagulant factors as a cause of stroke
heterozygous mutations
in the genes encoding proteins in the clotting cascade
(antithrombin III, proteins S and C) and from those that
disturb clotting balance (resistance to activated protein C,
or factor V Leiden mutation, and prothrombin mutations
as well as excess factor VIII)
34
___________ in young women with an established history of migraine as a risk for strokes, most of which occurred in the posterior circulation
prolonged
| aura
35
women who take oral
contraceptives in the childbearing years-particularly if
they are _________, _________, ________, _____________--are at increased risk of
cerebral infarction
older than 35 years of age and also smoke, are
| hypertensive, or have migraine
36
The vascular lesion underlying cerebral
| thrombosis in women taking oral contraceptives consists of__________
nodular intimal hyperplasia of eccentric distribution with increased acid mucopolysaccharides and replication of the internal elastic lamina.
37
The use of ________ has not been associated with stroke as far as can be currently determined
progestin-only
| pills or of subcutaneously implanted capsules of progestin
38
The risk of both
cerebral infarction and intracerebral hemorrhage appears
to be mainly in the________ period after delivery rather
than during the pregnancy itself
6-week
39
The occurrence of ________ embolus is always a
consideration in pregnancy because of a tendency to form clots in the pelvic and leg veins, coupled with increased right heart pressures
paradoxical
40
Atherosclerotic
plaques may be dislodged during ________ and are an important source of cerebral
emboli.
cross-clamping of the
| proximal aorta
41
Frequency of stroke depending on location
(1) the putamen and adjacent internal capsule (SO percent);
(2) the central white matter of the temporal, parietal, or frontal lobes (lobar hemorrhages, not strictly associated with hypertension);
(3) the thalamus;
(4) one or the other cerebellar hemisphere;
and (5) the pons
42
Phagocytosis of red cells begins within 24 h, and hemosiderin is first observed around the margins of the clot in ________
5 to 6 days
43
The _________ the appearance of contrast within the
hemorrhage during CT angiography, is associated with a
high rate of hematoma expansion
"spot sign,"
44
As _______ and _______ form, the hematoma signal becomes bright on Tl-weighted images and dark on T2
deoxyhemoglobin and
| methemoglobin
45
The hypertensive vascular lesion that leads t o arteriolar
rupture in most cases appears to arise from an arterial
wall altered by the effects of hypertension, i.e., the change referred to in a preceding section as ______ and _________
segmental lipohyalinosis and the false aneurysm (microaneurysm)
46
The immediate prognosis for large and medium-sized
cerebral clots is grave; some _______ percent of patients
die in 1 to 30 days.
30 to 35
47
Scoring system for ICH
incorporates the patient's age, size and location of hematoma, the presence of preexisting cognitive impairment, and Glasgow Coma score
FUNC
48
Scoring system for ICH
uses GCS, volume, presence of intraventricular hemorrhage, the location-supra- or infratentorial, and age above or below 80 years
ICH
49
Target Osm and serum Na in ICH Tx
osmolality kept at 295 to 305 mOsm/L and Na at 145 to
| 150 mEq
50
Findings of the STITCH Trial
failed to show a benefit from early surgery on survival or
| neurologic functioning at 6 months.
51
Hematomas that are _______or more in largest diameter,
especially if located in the vermis, pose the greatest risk,
and some surgeons have recommended evacuation of
lesions of this size no matter what the clinical status of the
patien
4 em
52
They take the form of small, thin-walled blisters
protruding from arteries of the circle of Willis or its
major branches
"berry" aneurysms.
53
aneurysmal process is initiated by focal destruction
of the__________ which is produced
by hemodynamic forces at the apices of bifurcations
internal elastic membrane,
54
4 MC sites of aneurysms
(1) the proximal portions of the anterior communicating artery,
(2) at the origin of the posterior communicating artery
from the stem of the internal carotid,
(3) at the first major bifurcation of the middle cerebral artery, and
(4) at the bifurcation of the internal carotid into middle and anterior cerebral arteries.
55
Aneurysms of the carotid artery that rupture in the
| cavernous sinus give rise to an ______
arteriovenous fistula
56
The
_______ is caused by a septic embolus that
weakens the wall of the vessel in which it lodges, almost
always at a site in a distal cerebral vessel, well beyond the
circle of Willis.
mycotic aneurysm
57
Fusiform deformities are
also referred to as _________, as they frequently
show atheromatous deposition in their walls, but
it is likely that they are at least partly developmental in
nature.
arteriosclerotic aneurysms
58
MC syndrome of SAH at the onset
severe generalized headache develops in the same
instantaneous manner but the patient remains relatively
lucid with varying degrees of stiff neck-the most common
syndrome
59
Percentage of Sz in SAH
Convulsive seizures, usually brief and generalized,
| occur in 10 to 25 percent
60
An aneurysm on the posteroinferior
or anteroinferior cerebellar artery may cause unilateral
______ or _______
occipital or cervical pain
61
approximately_______ percent
of patients with aneurysmal rupture will not have an
aneurysm evident.
5 to 10
62
Patients with the typical clinical picture of spontaneous
subarachnoid hemorrhage in whom an aneurysm
or arteriovenous malformation cannot be demonstrated
angiographically have a distinctly _______prognosis than
those in whom the lesion is visualized
better
63
T or F
MR1 detects most aneurysms of the basal vessels and
of their first branches but may not yet be of sufficient
sensitivity to replace CT or conventional angiography in
cases where an aneurysm is strongly suspected but too
small to be detected by MRA
T
64
Delayed and subacute hydrocephalus as a result of
blockage of the CSF pathways by blood may appear after
_______
2 to 4 weeks
65
smoothsurfaced,
sharply outlined collections of blood that cover
the retinal vessels-preretinal or subhyaloid hemorrhages. What is this syndrome?
Terson syndrome
66
ECG changes associated with SAH
The ECG changes include symmetrically large peaked T waves ("cerebral T waves") and other alterations, suggesting subendocardial or myocardial ischemia.
67
Reasons of volume contraction in SAH
bed rest, but sodium loss, probably
resulting from the release of atrial natriuretic factor
(ANF), a potent oligopeptide stimulator of sodium loss in
renal tubules, may also be a factor
68
In the hands of experienced anesthesiologists and cerebrovascular surgeons, the operative mortality, even in grades III and IV patients, has now been reduced to _________percent
2 to 3
69
the International Subarachnoid Aneurysm Trial Group randomly assigned more than 2,000 patients
to surgery or coil deployment; the overall rate of death or
dependence at 1 year was ______percent in the endovascular group and _____ percent in the operated group
24
31
70
Risk of rupture for unruptured aneurysm is dependent on:
size
71
Size of Giant Cerebral Aneurysm
>2.5cm
72
Mechanism of enlargement of giant aneurysms
They grow slowly by accretion of blood clot
within their lumens or by the organization of surface
blood clots from small leaks
73
duration of abx for Mycotic aneurysm
6 weeks
74
An___________ consists of a
tangle of dilated vessels that form an abnormal communication
between the arterial and venous systems
arteriovenous malformation (AVM)
75
In AVM, blood. The tangled blood vessels
interposed between arteries and veins are abnormally
________
thin and do not have the structure of normal arteries or
| veins
76
The two lesions-AVM and saccular aneurysm
(on the main feeding artery of the A VM)-are associated in
approximately _______ percent of case
5%
77
Onset of sx for AVM
between 10 and 30 years
78
When the vein of Galen is enlarged as a
result of drainage from an adjacent AVM,_______
may result, particularly in children
hydrocephalus
79
A systolic bruit
heard over the ______ in the neck or over the ______
process or the eyeballs in a young adult is suggestive of
an AVM.
carotid
mastoid
80
The summed score gives guidance as to the difficulty in
surgical removal and has a less certain relationship to
the clinical behavior of the lesion. What scoring system for AVM?
Spetzler and Martin
81
Factors increasing risk of bleeding for AVM
deep location of the AVM or deep venous drainage channels, and mostly, a previous hemorrhage
82
Rate of re-bleeding in AVM
The rate of rebleeding in most series has been
| 2 to 4 percent per year over decades but may be as high as 6 to 9 percent in the year after a first hemorrhage
83
The combination of a prolonged history of
_____________ in Adams'
series almost always indicated a large malformation
headaches, seizures, and a progressive deficit
84
T or F
The weight of evidence
suggests that the risk is raised by pregnancy alone in AVM
F
85
Arteriography is usually necessary to establish the diagnosis
with certainty and will demonstrate AVMs larger
than ____ mm in diameter
5
86
In AVM,
Grades_____ are generally not resected;
grade ________ lesions may be approached surgically
but often with preceding interventional embolization
of parts of the lesion
IV and V
III
87
Some _________percent of AV Ms
are amenable to block dissection, with an operative
mortality rate of 2 to 5 percent and a morbidity of 5 to
10 percent
20 to 40
88
This
approach is utilized most often with A VMs of 3 em or
smaller located in an area of the brain in which resection
would be likely to produce a serious neurologic disability.
radiosurgery
subnecrotizing stereotactically directed proton radiation
89
The main drawback to "radiosurgery"
| is that obliteration of AVMs occurs in ______
a delayed manner, usually with a latency of at least 18 to 24 months after treatment, during which the patient is unprotected from rebleeding
90
In radiosurgery,
After 2 years, ________ percent of AV Ms smaller than 2.5 em in diameter have been obliterated
75 to 80
91
Cx of RT
The first
is delayed radiation necrosis, which is predictable based
on the radiation dose, and the second is venous congestion
that occurs several weeks or months after treatment
92
Radiation necrosis may be reduced
by the administration of ________but the vascular
problem generally is not helped
corticosteroids
93
The defining features
are radiologic-a nidus of abnormal arteries and veins
with arteriovenous shunting contained entirely within
the leaflets of the dura.
D u ra l Arteriovenous Fistu l a
94
In DAVF,
The lesion is usually fed by dural arterial vessels derived from the internal cranial circulation and often, more prolifically, from the external cranial circulation (_______ and______
external carotid artery and muscular
| branches of the vertebral artery).
95
The ________ through dural fistulas accounts
| for the early opacification of the draining venous structures
rapid transit of injected angiographic dye
96
The best-defined examples of acquired
fistulas are those that arise adjacent to a_________ or in association with a ________, most
often of the transverse sigmoid sinus or adjacent to the
cavernous sinus.
venous sinus thrombosis
vascular atresia
97
Presentation of DAVF
Subdural hemorrhage is an infrequent but dramatic
mode of presentation, sometimes creating a large and
fatal clot; another syndrome is a cerebral-subarachnoid
hemorrhage, although this occurs with not nearly the
same frequency or severity as bleeding from brain
AVMs
98
Tx of DAVF
Treatment is by surgical extirpation or endovascular
embolization, at times a painstaking procedure because
of the multitude of potential feeding vessels
99
Cx of high flow DAVF especially in children
the high-flow lesions may shunt so much
| blood as to cause congestive heart failure, similar to arteriovenous malformations of the vein of Galen.
100
Vascular malformations composed mainly o f clusters
of thin-walled veins without important arterial feeders
and with little or no intervening nervous tissue make
up a significant group, some 7 to 8 percent of AVMs
Cavernous Ma lfo rm ations (Cavern o m a )
101
In Cavernomas, The incidence of bleeding is uncertain but is estimated to be __________ per year per lesion but quite often they are multiple lesions so that the cumulative risk in
any one patient is higher
less than 1 percent
102
Risk of bleeding in cavernomas
0.3 percent annually for
asymptomatic lesions and found that individuals who
had a previous episode of bleeding or had more than
one lesion were 2.5 times more likely to have another
hemorrhage.
103
In Cavernomas,
approximately 10 percent of these lesions
are multiple and _______ percent are familial
5
104
MRI of cavernoma
which discloses a cluster of vessels surrounded by
| a zone of hypodense ferritin in the T1-weighted images
105
About one-half of all cavernous angiomas lie in the
________ and in the past (before the availability of MRI),
many of them were misdiagnosed as multiple sclerosis
because of the stepwise accumulation of neurologic deficits with each hemorrhage
brainstem,
106
Cavernous angiomas on the surface of
the brain, within reach of the neurosurgeon, even those
in the brainstem, can be________
with low morbidity and mortality
plucked out like blackberries,
107
This i s perhaps the most common cerebral vascular malformation, estimated to occur in almost 3 percent of large autopsy series
D e e p ( Deve l o p m e nta l ) Ve n o u s A n o m a l y
108
The defining characteristics are of a caput medusa draining into a small collecting vein. The draining vein itself is often visualized most easily and fills with contrast concurrently with normal cerebral
D e e p ( Deve l o p m e nta l ) Ve n o u s A n o m a l y
109
When the bleeding is precipitated
by warfarin therapy, treatment with ________, _________, _________ and similar products, which contains
clotting factors, is recommended.
fresh-frozen
plasma and vitamin K, sometimes prothrombin complex
concentrate (PCC)
110
In the elderly, ________ appears to be a
major cause of lobar bleeding, especially if hemorrhages
appear in succession or are multiple
amyloid angiopathy
111
Greenberg and colleagues found that _________
the same marker that is overrepresented in Alzheimer
disease, is associated with severe amyloid angiopathy
and a risk of intracerebral hemorrhage, but others have
found an association with the E2 allele
apolipoprotein E4,
112
Primary intraventricular
hemorrhage, a rare event in adults, can sometimes
be traced to a __________ and _________ or one of the choroidal arteries
vascular malformation or neoplasm of
| the choroid plexus
113
Multiple small hemorrhages, brain "microbleeds,"
are most commonly considered to be the result of _________ , but may
also be associated with_____
vascular amyloid
chronic hypertension
114
The pathologic entity called brain purpura (pericapillary
encephalorrhagia), incorrectly referred to as _____________consists of multiple petechial
hemorrhages scattered throughout the white matter
"hemorrhagic
| encephalitis,"
115
In hemorrhagic encephalitis
The lesions in brain purpura are
small, 0.1 to 2.0 mm in diameter, and are confined to the
white matter, particularly the ____,________,______
corpus callosum, centrum
| ovale, and middle cerebellar peduncles
116
This angiopathy consists of the deposition of amyloid in
the media and adventitia of small vessels, predominantly
in the meninges, cortex, and cortical penetrating vessels
CAA
117
There is a separate familial amyloidotic condition of
diffuse white matter degeneration with dementia, associated
in some families with calcification in the occipital
lobes, and the aforementioned mutations in the _______
gene cause a disruption of the small vessel wall that can
cause small cerebral hemorrhages that are similar to those
of cerebrovascular amyloid
COL4A
118
_________ is the term applied to a relatively
rapidly evolving syndrome of severe hypertension
in association with headache, nausea and vomiting, visual disturbances, confusion, and-in advanced cases-stupor and coma.
Hypertensive encephalopathy
119
MRI findings of HPN encephalopathy
bilateral increase in T2 signal intensity in the
white matter on .MRI and a corresponding reduced density
on CT, usually concentrated in the posterior part of
the hemispheres
120
Hypertensive encephalopathy and eclampsia may
cause _________. Most such cases are
not caused by the rupture of an intracranial aneurysm
subarachnoid hemorrhage
121
Pathophysio of brain edema in HPN encephalopathy
The brain edema is the result of active exocytosis of water rather than simply a passive leak from vessels subjected to high pressures
122
Target BP for HPN Enceph
a safe target is a pressure of 150 / 1 00 mm Hg
| or a 20 percent reduction in mean pressure
123
Anti-HPN for HPN enceph
intravenous sodium nitroprusside, 0.5 to 0.8 mg/kg/min;
a calcium channel blocker such as nifedipine, 10 to 20 mg
sublingually;
or intravenous beta-adrenergic blockers (labetalol, 20 to 40 mg intravenously followed by an infusion at 2 mg/min, or esmolol are favored)
124
This type of vasculopathy is produced by sympathomimetic
drugs alone, such as ephedra in health food
supplements, phenylpropanolamine, pseudoephedrine,
methamphetamine, and cocaine
DIFFUSE CEREBRA L VASOSPASM
( R EVERSIBLE CERE BRAL
VASOCONSTRICTIO N SYN DROM E [RCVS],
CALL-FLE M I N G SYN DROM E)
125
Most feared cx of Giant Cell Arteritis
Occlusion of branches of the ophthalmic
artery (mainly those to the posterior ciliary artery
and the choroidal circulation that supply the anterior
optic nerve) results in blindness in one or both eyes, is the most feared complication, often unpredictably
126
In Giant Cell Arteritis, The administration of prednisone, ____________provides striking relief of the headache and polymyalgic symptoms within days and sometimes within hours, and also prevents blindness.
50 to 75 mg/ d,
127
This i s a nonspecific chronic arteritis involving mainly
the aorta and the large arteries arising from its arch. It
is similar in some ways to giant cell arteritis except for
its propensity to involve the proximal rather than the
distal branches of the aorta.
Ta kayasu D i sease ( " P u l se l ess D i sease " )
128
Mechanism of Takayasu
The etiology has never been ascertained
| but an autoimmune mechanism is suspected
129
Arteries involved in Takayasu
brachiocephalic, subclavian, carotid, vertebral,
and other arteries that may be asymptomatic or
cause neurologic ischemic symptoms
130
Pathology of Takayasu
periarteritis
of the large vessels, often with giant cells and reparative
fibrosis.
131
_______when injected intravenously more so than when
used intranasally, is prone to cause cerebral hemorrhage
as a result of acute hypertension, similar to the bleeding
that may be precipitated by other sympathomimetic
drugs such as amphetamine and phenylpropanolamine
```
cocaine hydrochloride (the usual form of ingestible
cocaine)
```
132
The strokes
| with crack cocaine, however, are more often _______
ischemic,
| typically involving the territory of a large vessel
133
Crack cocaine may also cause a _____________ not unlike that associated with
antiphospholipid antibody but generalized rather than
focal
choreiform disorder
| ("crack dancing"),
134
This i s yet another poorly understood form of vasculitis,
consisting of a microangiopathy affecting mainly the brain
and retina. Psychiatric symptoms, headache, dementia,
sensorineural deafness, vertigo, and impairments of vision
are the clinical manifestations
S u sac Sy n d ro m e
135
In Susac syndrome, The MRI may show characteristic white
| matter lesions, particularly in the ____
corpus callosum
136
The administration of drugs such as _____, ________, and _______ and even the hypercoagulable
reaction to heparin that is associated with
thrombocytopenia have all been cited as risks for cerebral venous thrombosis
tamoxifen,
| bevacizumab, and erythropoietin,
137
Thrombosis of the vein
of Labbe causes infarction of the underlying________ and occlusion of the vein of Trolard implicates
the _______
superior temporal lobe,
parietal cortex
138
Increased intracranial pressure without ventricular
| dilatation occurs with thrombosis of the :
superior sagittal
sinus, the main jugular vein, and the transverse sinus or
the confluence of the sinuses
139
Once a venous thrombosis
becomes established for several days or longer, the tributary
surface veins take on a ________appearance that is
appreciated on the venous phase of an angiogram
"corkscrew"
140
In Cavernous sinus thrombosis, Also involvement of the _________
may be accompanied by a fifth nerve palsy
superior petrosal sinus
141
Occlusion of the ______ and ______ is the least common and clinically most obscure of
the venous syndromes
vein of Galen and of the internal cerebral
| veins
142
the overall mortality rate
remains high, with large hemorrhagic venous infarctions
found in ______ percent of cases
10 to 20
143
Sterile vegetations, referred to also as ___________, consist of fibrin and platelets and are loosely attached to the mitral and aortic valves and contiguous endocardium
nonbacterial thrombotic endocarditis
144
The essential pathologic change in ______ is the occurrence
of widespread fibrin thrombi in small vessels,
resulting in numerous small infarctions of many organs,
including the brain
DIC
145
Ab associated with APAS
l upus an ticoagulant and
| anticardiolipin
146
The most frequent neurologic abnormality in APAS is a TIA,
often taking the form of ________`, with or without retinal arteriolar or
venous occlusion
```
amaurosis fugax (transient monocular
blindness)
```
147
The _______`is an arteriopathy producing
deep blue-red skin lesions of livedo reticularis and
livedo racemosa in association with multiple ischemic
strokes. Many, but not all, patients have high titers of
antiphospholipid antibodies
Sneddon syndrome
148
In APAS asscoiated strokes, Warfarin, the definitive therapy, alters the testing for antibodies and several guidelines recommend confirming the presence of antibodies after_______ before starting treatment
INR must be maintained close to _______for
effective prevention of stroke
an interval of two weeks
3
149
T or F
in APAS
Aspirin, on uncertain grounds, is thought
not to confer protection for stroke
T
150
T or F
in APAS
In "catastrophic" cases
with repetitive strokes, intravenous immunoglobulin and
plasma exchange have been used with some effect
T
