Cyclosporins Flashcards
1
Q
What is therapeutic range for cyclosporine?
A
C0 100-500 mcg/L
C2 600-1700 mcg/L
2
Q
What is the half life for cyclosporine?
A
8.4 hours
3
Q
What are the enzymes that are responsible for cyclosporine metabolism?
A
CYP 450 , CYP 3A4 .CYP 3A5
4
Q
What is the volume of distribution for cyclosporine?
A
3-5 L/Kg
5
Q
Protein binding of cyclosporine is?
A
90-98% to lipoproteins
6
Q
What is the dosage for cyclosporine in graft versus host prophylaxis? In pediatrics
A
IV: 1.5 mg/Kg in 2 divided doses
PO: 6.25 mg in 2 divided doses
7
Q
Time to reach cyclosporine study state?
A
3-5 days
