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farmacotherapie 2 > CYP > Flashcards

CYP Flashcards

(57 cards)

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1
Q

theofylline

A

CYP2A1 substraat

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2
Q

fluvoxamine

A

CYP1A2, CYP2C19 inhibitor

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3
Q

carbamazepine

A

CYP1A2, CYP2C9, CYP3A4 inductor

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4
Q

fenytoïne

A

CYP1A2, CYP2C9, CYP3A4 inductor

CYP2C19, CYP2C9 substraat

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5
Q

rifampicine

A

CYP1A2, CYP2C9, CYP2C19,CYP2D6, CYP3A4, pgp inductor

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6
Q

sigarettenrook

A

CYP1A2 inductor

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7
Q

hypoglycemierende sulfamide

A

CYP2C9 substraat

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8
Q

diazepam

A

CYP2C19 substraat

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9
Q

alprazolam

A

CYP3A4 substraat

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10
Q

zolpidem, zopiclone

A

CYP3A4 substraat

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11
Q

antacida/melk+quinolone

A

complexvorming => gedaalde absorptie

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12
Q

antacida/melk+tetracycline

A

complexvorming => gedaalde absorptie

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13
Q

antacida/melk+Levothyroxine

A

complexvorming => gedaalde absorptie

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14
Q

antacida/melk+bisfosfonaten

A

complexvorming => gedaalde absorptie

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15
Q

antacida+ itraconazole

A

verandering in GI pH=> gedaalde oplosbaarheid/BB

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16
Q

PPI +itraconazole

A

verandering in GI pH=> gedaalde oplosbaarheid/BB

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17
Q

H2 antihistaminica+ itraconazole

A

verandering in GI pH=> gedaalde oplosbaarheid/BB

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18
Q

simvastatine+clarithromycine

A

CYP3A4 subs + CYP3A4 inh

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19
Q

duloxetine

A

SNRI, CYP1A2, CYP2D6 sub+ CYP2D6inh

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20
Q

fenobarbital

A

CYP1A2, CYP2C9, CYP3A4 inductor

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21
Q

dextrometorfan

A

CYP2D6 subs

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22
Q

amitriptyline

A

CYP2D6 subs

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23
Q

haloperidol

Study These Flashcards
A

CYP2D6 subs, QT verlenging

24
Q

paroxetine

Study These Flashcards
A

CYP2D6 subs/inh

25
venlafaxine
SNRI, CYP2D6 subs
26
fluconazole
CYP2C9 inh
27
miconazole
CYP2C9 inh
28
escitalopram
SSRI, CYP2C19 subs, QT verlenging
29
terbinafine
CYP2D6 inh
30
clarithromycine
CYP3A4 inh, QT verlenging
31
erithromycine
CYP3A4 inh, QT verlenging
32
telithromycine
CYP3A4 inh
33
itraconazole
CYP3A4 inh
34
ketoconazole
CYP3A4 inh
35
posaconazole
CYP3A4 inh
36
voriconazole
CYP2C9/CYP3A4 inh
37
digoxine
pgp subs
38
st janskruid
CYP3A4/pgp inductor
39
loperamide
pgp subs
40
risico op hyperkaliëmie
- kalium supplementen - GM die aldosteron secretie verminderen: ACE-I, reninine inh, sartanen, NSAID - GM die binding aldosteron aan recep inh: spironolactone, canrenoaat, eplerenon - GM die renale epithelialen NA kanalen inh: kaliulmsparende diuretica (spironolactin en eplerenon), trimethoprim
41
risico op serotonerg syndroom
AD+ antimigraine GM (triptanen, ergotamines) combo van AD (SSRI, SNRI, MAO inh, lithiumzouten, Sint-jans kruid) AD+ dextrometorfan AD+ tramadol, hydromorfon, pethidine
42
pimozide
antipsychoticum, QT verlenging
43
sertindol
antipsychoticum, QT verlenging
44
droperidol
antipsychoticum, QT verlenging
45
flecainide
anti aritmicum, QT verlenging
46
sotalol
anti aritmicum, QT verlenging, niet selectieve BB
47
amiodaron
anti aritmicum, QT verlenging, CYP2C9 inh
48
disopyramide
anti aritmicum, QT verlenging
49
moxifloxacine
quinolone AB, QT verlenging
50
domperidon
QT verlenging, gastroprokineticum
51
carvedilol
niet selectieve BB
52
propranolol
niet selectieve BB
53
pindolol
niet selectieve BB
54
midazolam
benzo, CYP3A4 subs
55
triazolam
benzo, CYP3A4 subs
56
dexamethasone
cortico, CYP3A4 subs
57
omeprazole
PPI, CYP2C19 inh

farmacotherapie 2 (6 decks)

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