CYP450 enzymes

Question 1

Which class III antiarrhythmics cause QT prolongation?

Answer 1

sotalol and amiodarone

Question 2

What is the standard of treatment for angioedema if cause still uncertain?

Answer 2

epinephrine, methylprednisolone, diphenhydramine,
TXA- beneficial for hereditary angioedema; it inhibits the conversion of plasminogen to plasmin which is a critical step in kalikkrein activation
FFP also , since pt may need intubation

Question 3

List drugs that will interact with iron and results in decrease GI absorbtion. (iron is a cation)

Answer 3

tetracyclines, levothyroxine, fluoroquinolones

Question 4

Tyrosince kinase inhibitor like erlotinib- what can decrease absorption?

Answer 4

antacid

Question 5

What can increase the free dilantin level

Answer 5

high BUN and low albumin

Question 6

What is the treatment for candida albicans

Answer 6

micafungin- moderate to severe illness, when stable can transition to fluconazole, if these 2 not working, use amphotericin B

Question 7

2D6 inhibitors

Answer 7

fluoxetine

paroxetine

Question 8

Phase I Enzymes

Most Common Enzymes

Answer 8

3A4

2D6

2C9

1A2

2C19

2E1

2B6

Question 9

Calcium Channel Blockers (Sub/Inhib of 3A4;pgp)

Answer 9

Diltiazem:

Levels affected by cimetidine and ranitidine (dec)

Protease inhibitors (inc)

Verapamil:

Levels affected by pehnobarbital and primidone (dec)

phenytoin (dec)

rifampin (dec)

St Johns Wort (dec)

Digoxin, erythromycin , lovastatin, simvastatin (all inc)