Cyst of the jaw Flashcards

(47 cards)

1
Q

what is a cyst

A

pathologicalcavity filled with fluid, semi fluid or gasous content. Not created by pus accumulation

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2
Q

how are cysts classified

A
  1. epithelial lined (most)
  2. odontogenic/non odontogenic
  3. inflam/developmental
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3
Q

appropriate further inv of a cyst

A

plain Rg - OPT/PA/occ
other views - occipitomental/PA mandible
CBCT

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4
Q

should a biopsy be taken - how

describe cystic fluid

A

wide bore needle - FNA
blood/cystic fluid/air/pus
-clear straw coloured fluid (crystals present)

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5
Q

what is the purpose of an incisional biopsy - when

- how

A

to take a sample of cyst lining for histological analysis

  • during marsupilisation
  • usually under L.A.; select place where “cyst” appears superficial; raise mucoperiosteal flap; remove bone as required – using rongeurs or a round bur; incise and remove a section of lining
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6
Q

name the types of cysts of the jaw

A

odontogenic

  • radicular
  • dentigerous
  • keratocyst (keratocystic odontogenic tumour)

non odontogenic

  • nasopalatine
  • stafne cavity
  • aneurysmal bone cyst
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7
Q

sources of epithelium for odontogenic cysts

A
  • rests (debris)of malassez, hertwig’s root sheath
  • rests of serres - lamina remnants
  • reduced enamel ep
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8
Q

radicular cyst

  • what
  • synonyms
  • aetiology
  • features
A

periapical cyst attached to the apex of a NV tooth
inflammatory origin = pulpitis then PA granuloma then cyst
- periapical/dental cyst
-slow painless swelling, no symps until big enough to be noticed
-at first = hard and rounded, later eggshell thickness and cracking on pressure. Eventually wall resorbed leaving soft bluish swelling.
- originate from rests of malassez (hertwig’s root sheath)

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9
Q

radicular cyst - histology

A

epithelial lining (often incomplete), CT capsule,
plasma cells and macrophages - inflammation
-peripherally osteoclasts allow bony expansion, osteocblasts react to inflammation by depositing bone causing corticated margin.

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10
Q

name 2 variations of a radicuar cyst

A

residual cyst

inflamatory lateral periodontal cyst

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11
Q

what is a dentigerous cyst

A

a developmental cyst surrounding the crown of an unerupted tooth

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12
Q

who and where are dentigerous cysts most likely to occur

A

male>female
mandible>max
Lower 8’s and up 3’s

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13
Q

histology of a dentigerous cyst

A

thin non keratinised stratified squamous epithelium
- arises from separation of reduced enamel epithelium and fromation of follicular space - internal pressure causes expansion of this

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14
Q

clinical features of dentigerous cyst

Rg features

A
  • grow by internal pressure - expansion and displacement of adjacent structures. Slow growing
  • developmental but can be caused by inflammation of pericoronitis/adjacent NV teeth.
  • Rg - circumscribed, rounded and unilocular. Contain crown of tooth.
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15
Q

what condition can appear with multiple dentigerous cysts

name one other feature of this condition

A

cleidocranial dysplasia
partly missing collarbones = hypermobility
prognathic mandible
hyperdontia - many supernumeraries

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16
Q

measurements of dentigerous cyst and follicle

A

-<2.5mm = follicle
-> 4.2mm = probable cyst
>10mm - definite cyst
asymmetrical radiolucency = cyst

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17
Q

what is an odontogenic keratocyst
who
clinical presentation

A
developmental cyst
m>f
mostly mandible -third molar and ramus
multilocular
- symptomless until infected
recurrence issue
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18
Q

cyst aspirate of a keratocyst

histology

A

white keratin - contains sqaumes - low soluble protein content
-parakeratosis of cyst lining, basal palisading

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19
Q

why is recurrence likely to occur for a keratocyst

A

thin friable lining - left behind
many daughter cysts missed
cell nests

20
Q

what syndrome is associated with multiple keratocysts

other features

A

gorlin-goltz syndrome (basal cell naevus)
autosomal dominant
skeletal abnormalities and basal cell carcinomas
-frontal & temporalparietal bossing hypertelorism
mild mandibular prognathism
Abnormalities of Ca & PO4 metabolism

21
Q

appearance of a keratocyst on a Rg

growth pattern

A

well defined radiolucent area, scalloped margin , usually ramus/3rd molar, sharply demarcated
- pattern = extensive spread forwardand backward along medullary cavity. MINIMAL expansion
AP growth

22
Q

pathogenesis of an odontogenic keratocyst

A

develop from rests of odontogenic epithelium left after tooth development - eg rests od serres
-Mutation/deletion/inactivation of ptch gene (tumour suppressor gene)

23
Q

nasopalatine cyst
origin
where
presentation

A

found in midline - incisive canal

  • epithelial reminants of nasopaltine duct
  • dependant on canal affected - superficial soft tissue cyst, can grow primarily into nose - salty discharge
24
Q

what differentiates odontogenic and non odontogenic cysts

A

distibution of cytokeratin in cyst epithelium

25
Rg and pathological features nasopalatine cyst
Radiograph Well-defined round, ovoid or heart shaped radiolucency Sclerotic margin anterior region of palate Pathology Lined by st. squ. Respiratory or cuboidal epithelium Neurovascular bundles found in capsule
26
solitary bone cyst (simple bone cyst) | clinical features -who, where
child & adults premolar/molar region asymp, chance finding on Rg
27
Rg features of solitary bone cyst -surgical exploration findings
variable sized radiolucency, irregular margin, well defined. Scalloping! Rough bony-walled cavity devoid of any detectable lining. NO epithelial lining Rapid healing follows Although will resolve spontaneously without
28
Aneurysmal bone cyst clinical Rg
Clinical Children or young adults Mandible, post. part of body or angle Firm, painless swelling Radiograph Uni- or mulitilocular radiolucency with a ballooned out appearance due to gross cortical expansion
29
Aneurysmal bone cyst | pathology
``` numerous, non-endothelial lined, blood-filled spaces varying size separated by cellular fibrous tissue multinucleated giant cells Pathogenesis unknown Many preceded by other 10 lesion of bone ```
30
Stafne idiopathic bone cavity - what | Rg features
developmental anomaly of mandible asymptomatic - Radiograph Round or oval, well demarcated radiolucency Between premolar region & angle of jaw usually located below inferior dental canal
31
Stafne idiographic bone cavity -surgical exploration
Depression or concavity lingual aspect of mandible Varying depth Majority of cases, contains ectopic salivary tissue in continuity with SMG
32
``` Ameloblastoma features -age -features -site/shape - ```
Aggressive tumour originates from remnants of odontogenic epithelium of enamel organ/dental lamina PEAK AGE: adults (Usually >40 years old) FREQUENCY: Rare, but still most common odontogenic tumour SITE & SIZE: Posterior body/angle/ramus of mandible. Occasionally maxilla. Size very variable depending of age of lesion but can become very large and disfiguring SHAPE: multilocular, occasionally monolocular at early stage. Well defined and well corticated.
33
Ameloblastoma - radiodensity - signs,symps - treatment
RADIODENSITY: Radiolucent with internal radiopaque septae ``` SIGNS AND SYMPTOMS: early stages asymptomatic adjacent teeth displaced facial deformity extensive expansion in all directions expansion usually bony hard and non tender (latter stages may get “egg shell crackling”) ``` TREATMENT: Surgical resection with margin normal bone.
34
``` Ameloblastoma fibroma -age -frequency -site/shape clinical features ```
Rare, benign mixed odontogenic tumour originating from both odontogenic epithelium and connective tissue of developing tooth germ. Radiographically closely resembles ameloblastoma but develops in younger age group AGE: Children and adolescents FREQUENCY: Rare SITE & SHAPE: Usually mandible in premolar/molar region. Variable size. Multilocular (monolocular in early stages). Smooth outline. Well defined and well corticated -adjacent teeth displaced
35
Calcifying odontogenic cyst - age - site - size/shape - radiodensity - effect
AGE: wide age range but usually < 40 years old SITE: 75% are intraosseous and either jaw may be involved. Majority arise anterior to first permanent molar. SIZE&SHAPE: Usually small about 1-3 cm in diameter. Shape is variable but usually monolocular. RADIODENSITY: initially radiolucent but in more advanced stage contains a variable amount of calcified radiopaque material EFFECTS: adjacent teeth usually displaced +/or resorbed. Bony expansion.
36
odontogenic myxoma and fibroma - age - site - shape/size - Rg
Very similar non-invasive tumours which originate from odontogenic CT fibroblasts of the developing tooth germ, which produce either excessive fibrous collagen (FIBROMA) or excessive ground substance (MYXOMA). Radiographically often indistinguishable. AGE: Young adults SITE: Usually posterior mandible or maxilla May arise in relation to root of tooth/crown or unerupted tooth or may take place of tooth missing from arch SIZE&SHAPE: Size is variable but may become large if left untreated. Usually multilocular -Rg -radiolucent with fine radiopaque septa -adjacent teeth loosened/displaced
37
chondroma - what - where
Rare, benign slow growing tumour producing a rounded lobulated radiolucency of variable definition within the bone with a variable amount of internal calcification Anterior maxilla and posterior mandible most common sites. Although can also occur in the condylar and coronoid process. -intrinsic primary benign bone tumour
38
Central haemangioma - what is it - age - radiograph appearance
Rare benign tumour that occasionally affects the jaws, particularly the mandible. It is usually a developmental malformation (hamartoma) of the blood vessels in the marrow spaces. Can present at any age but usually adolescents Variable radiograpgic appearance including; moderately well defined zone of radiolucency within which trabeculae spaces are enlarged. Lesion presents therefore as multicystic “saop bubble or honecomb” appearance
39
Osteosarcoma - age - site - signs/symptoms
Commonest primary malignant tumour of bone but is relatively rare in jaws. AGE: Usually around 30 years old at diagnosis. Occasionally, tumour presents in older patients eg in association with Paget’s disease of bone. SITE: Slightly more common in mandible than maxilla SIGNS + SYMPTOMS: Fairly rapidly enlarging swelling that may be accompanied by pain, numbness of lip, trismus and displacement of teeth. Ulceration of overlying skin and mucosa is a late feature.
40
Osteosarcoma Rg features prognosis
RADIOGRAPHIC APPEARANCE: variable and depends on amount of normal bone destroyed by tumour and amount of neoplastic bone formed within lesion. Predominately osteolytic tumours produce irregular areas of radiolucency wheras sclerosing types in which tumour bone is formed, produce irregular areas of radiopacity. The two patterns may co-exist in the same tumour. A symmetrically widened PDL space has been reported as a feature of very early lesions PROGNOSIS: Overall 5 year survival for osteosarcoma of jaws is about 40%. Jaw lesions,in contrast to osteosarcomas at other sites, metastasise infrequently. However local recurrence rates are high.
41
Multiple myeloma - age - site - site/shape - radiodensity - effects
AGE: Adults, middle aged SITE: Multiple lesions affecting - skull vault - posterior part of mandible - other parts of skeleton SIZE&SHAPE: Variable size. Round monolocular shape though multifocal. Well defined outline. Not corticated. RADIODENSITY: Radiolecent EFFECTS: Enlargement/Coalescence may lead to pathological fracture
42
central giant cell granuloma - age - site - size/shape - radiodensity - effect
Uncommon, non neoplastic mass in the jaws producing an expansile radiolucent lesion. AGE: Variable but usually young adolescents and adults under 30 years old. SITE: Anterior mandible. In region of deciduous dentition, often crossing midline. SIZE&SHAPE: Variable size. Can be up to 10 cm. Usually multilocular with well defined and well corticated outline. RADIODENSITY: Radiolucent -adjacent teeth displaced or resorbed
43
cherubism - age - site - size/shape - radiodensity - effect
Inherited disorder. Usually autosomal dominant but many cases appear spontaneously. Radiographically lesions resemble closely other giant cell containing lesions. AGE: Children 2-6 years old SITE: Angle/Posterior mandible - bilateral SIZE&SHAPE: Variable size, up to several cms diameter. Multilocular with bilateral lesions typically symmetrical. RADIODENSITY: Radiolucent with internal radiopaque septa EFFECTS: Gross displacement of deciduous/permanent teeth. Extensive buccal/lingual expansion
44
Fibrous dyplasia - age - site - size/shape - radiodensity - effect
Considered to represent a developmental tumour like lesion. Most cases (80%) are monostotic (limited to a single bone, often the jaw). AGE: 10 - 20 years of age SITE: Usually posterior maxilla SIZE&SHAPE: Variable size. Round shape. Poorly defined outline with no cortiaction RADIODENSITY: Initially radiolucent. Gradually becomes radiopaque to produce “ground glass” or “orange peel” -teeth displaced
45
what cysts are best treated by enucleation | -complications
keratocyst / dentigerous cys t/ radicular and residual cyst ``` Complications: Mainly related to size, position and type of cyst interference with IDC communication with Maxillary sinus pathological fracture Recurrence ```
46
Masurpilisation for? complications
Fenestration’ +/- grommet insertion Useful for large simple cysts, keratocyst, dentigerous cysts ``` Complications: Needs further surgery for removal cyst Long treatment before completion chance of re-infection? Uncomfortable with grommet in situ? ```
47
ameloblastoma/sarcoma treatment
Removal of cyst with margin of ‘normal’ bone. Mainly used for ameloblastoma/sarcoma cases Normally have to have secondary procedure for reconstruction of defect