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Flashcards in Cystic Fibrosis Deck (11):
1

How common is it to carry the CF gene?

1 in 25

2

What causes dry secretions in CF?

CFTR protein- altered ion transportation resulting in less H2O in lumen

3

Which mutations are common in CF?

F508del
G551D

4

Who gets a CF genetic test?

bronchiectasis under 40
Upper lobe bronchiectasis
Colonisation with staph
Infertility
Low weight

5

What are some difficulties of CF?

Burden
Preventative treatment
Complications can be rapid in onset

6

What are antibiotics for colonised staph aureus?

Oral fluclox
Oral Septrin

7

what are antibiotics for colonised pseudomonas?

Oral azithromycin
Nebulised colomycin/tobramycin/aztreonam
Inhaled Tobramycin

8

How many antibiotics should be given?

2 minimum

9

what is OHPAT?

continuity of IV antibiotics at home

10

What drug targets G551D mutation?

Ivacaftor
(increased affect with grapefruit)

11

what drug is for F508del mutations?

Lumacaftor
(to be used with ivacaftor too)