Cystic Fibrosis- Treatment

Question 1

Dornase Alfa

Answer 1

Break down extracellular DNA in the lungs. Pulmonary secretions extracellular DNA released by degenerating leukocytes. Hydrolyses DNA in sputum of CF patients and reduce viscosity + viscoelasticity. Enzyme does not appear to effect sputum in absence of inflammatory response to infection or effect healthy individuals

Question 2

Bronchodilators

Answer 2

Open or widen airways, specifically bronchi/ bronchioles. Make breathing easier- air in mucus out. 20 minutes to work, lasts 4-6 hours.

Question 3

Beta-Agonists

Answer 3

Albuterol

Levabuterol

Question 4

Physiotherapy

Antigenic Drainage

Positive Expiratory Pressure

Answer 4

Active cycle of breathing techniques: cycle of deep breathing, huffing, coughing and relaxed breathing to move mucus
Moves mucus from smaller to bigger airways using controlled breathing at different levels
Breathing out through a mask or mouthpiece against a resistance to build up pressure to move mucus

Question 5

Antibiotics

Answer 5

Limiting growth bacteria of bacteria cells by interfering with bacterial protein synthesis, DNA replication, or other aspect of bacteria cellular metabolism