Cytochrome P-450 interactions Flashcards Preview

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Flashcards in Cytochrome P-450 interactions Deck (24)
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1
Q

Inducers of P-450

Chronic alcholic mona steals phen-phen never refuses greasy carbs

A
  • chronic alcohol
  • Modanfil (narcolopsy)
  • St. Johns work (hypericum perforatum)
  • Phenytoin (seizures)
  • Phenobarbital (long active seizure control)
  • Nevirapine (NNRT)
  • Rifampin (- DNA dependent RNA polymerase)
  • Griseofulvin (oral anti-fungal: ring worm)
  • Carbamazepine (seizure, nerve damage or bipolar)
2
Q

Inhibitors of P-450

Acute Gentaleman Gipped Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon Rolls

A
  • Acute alchol abuse
  • Gemfibrozil (high cholesterol, TTG)
  • Ciprofloxanin (quinolone)
  • Isoniazid (TB)
  • Grapefruit juice
  • Quinidine (irregular HB, Class I)
  • Amiodarone (life threatening arrhythmias)
  • Ketoconazole (seborrheic dermitits: tinea corpis)
  • Macrolides (- 50S)
  • Sulfonamides (- folate synthesis)
  • Ritonavir ( protease -)
3
Q

Define the substrates in P-450

Always, Always, Always, Always, think when starting others

4-A’s and TWOS

A
  • Anti-epileptics
  • Anti-depressents
  • Anti-psychotics
  • Anesthetics
  • Theophylline
  • Warfarin
  • Statins
  • OCPs
4
Q

Inducer/inhibitors

chronic alcohol use

A

Inducer

5
Q

Inducer/inhibitor

Modafinil

A

Inducer

6
Q

Inducer/inhibitor

St. John wort

A

Inducer

7
Q

Inducer/inhibitor

Phenytoin

A

inducer

8
Q

Inducer/inhibitor

Phenobarbital

A

inducer

9
Q

Inducer/inhibitor

Nevirapine

A

inducer

10
Q

Inducer/inhibitor

Rifampin

A

Inducer

11
Q

Inducer/inhibitor

Griseofulvin

A

Inducer

12
Q

Inducer/inhibitor

Carbamazepine

A

Inducer

13
Q

Inducer/inhibitor

Acute alcohol abuse

A

inhibitor

14
Q

Inducer/inhibitor

Gemfibrozil

A

inhibitor

15
Q

Inducer/inhibitor

Ciprofloxacin

A

inhibitor

16
Q

Inducer/inhibitor

Isoniazid

A

Inhibitor

17
Q

Inducer/inhibitor

Grapefruit juice

A

inhibitor

18
Q

Inducer/inhibitor

Quinidine

A

Inhibitor

19
Q

Inducer/inhibitor

Amiodarone

A

inhibitor

20
Q

Inducer/inhibitor

Ketoconazole

A

inhibitor

21
Q

Inducer/inhibitor

Macrolides

A

Inhibitor

22
Q

Inducer/inhibitor

Sulfonamides

A

inhibitor

23
Q

Inducer/inhibitor

Cimetidine

A

inhibitor

24
Q

Inducer/inhibitor

Ritonavir

A

inhibitor