Cytokines Flashcards Preview

Immunology > Cytokines > Flashcards

Flashcards in Cytokines Deck (20):
1

IL-1 alpha and beta

-macrophages and epithelial cells
-induces fever, proinflammatory

2

IL-2

-T cells (naive, Th0, Th1)
-growth factor

3

IL-4

-Th2, mast cells
-Th2 differentiation, B activation, B switch to IgE

4

IL-5

-Th2, mast cells
-promotes eosinophelia

5

IL-6

-Th2, macrophages, endothelial
-T and B growth, acute phase proteins, induce fever

6

IL-7

-stromal cells
-B and T progenitors

7

IL-10

-monocytes, T, certain B
-suppress macrophages and CTL, B growth factor

8

IL-12

-macrophages, dendritic cells
-Th1 differentiation, activates NK

9

IL-13

-Th2
-B and T growth, acute phase proteins, fever, inhibits macrophages

10

IL-17

-Th17 T cells
-neutrophil production, proinflammatroy

11

IL-21

-Th2
-proliferation of B, T, NK

12

IL-22

-NK, Th17
-acute phase proteins, proinflammatory

13

IL-23

-DC, mono, macro
-Development and proliferation of Th17

14

TNF-alpha

-macro, NK, T
-imflammation

15

Lymphotoxin-alpha

- B and T cells
- apoptosis of target

16

BAFF (blys)

-B cells
-B cell proliferation, maturation, survival

17

TGF-beta1

-mono, T, Bsub
-inhibits growth; antiinflammatory; IgA switch

18

IFN-alpha

-all nucleated
-anti-viral; increases MHC1

19

IFN-beta

-fibroblasts
-antiviral; increases MHC1

20

IFN-gamma

- T and NK
- increases macro activation, MHC1 and MHC2 expression, increases Ag processing, Inhibits Th2