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Flashcards in Cytokines Deck (14)
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1
Q

IL-1

A

Osteoclast activating factor
Causes fever, inflammation
Activates endothelium to express adhesion molecules
Induces cytokine secretion to recruit WBC

2
Q

IL-6

A

Acute phase protein secretion and fever

3
Q

IL-8

A

Neutrophilic chemotactic factor

4
Q

IL-12

A

Activate TH1

Activate NK cells

5
Q

TNFa

A
Mediates septic shock
Activates endothelium
causes WBC recruitment 
vascular leak
** mediates cachexia in malignancy
6
Q

Secreted by T cells

A

IL-2, IL-3

7
Q

IL-2

A

proliferation of all lines of T cell

Proliferation of NK cells

8
Q

IL-3

A

Acts like G-CSF: bone marrow prolifereation and differentiation

9
Q

Secreted by TH1 cells

A
IFNg
Stimulates macrophages 
Also activates NK cells 
Inc. expression and antigen presentation on all cells 
(accts via the JAK-stat pathway)
10
Q

From TH2 cells

A

IL-1, IL-5, IL-10

11
Q

IL-4

A

beg 4 it

  • mediations proliferation of B cells
  • Class switching to IgE and IgG
  • TH2 stimulation
12
Q

IL-5

A

Class switching it IgA

Differentiation and prolifeation of eosinophils

13
Q

IL-10

A

Modulates the inflammatory response
Dec. the expression of MCH2 and TH1 cytokines
Inhibits activated macrophages and dendritic cells
Secreted by regulatory cells along with TGF-B

14
Q

Secreted by Macrophages

A

IL-1, IL-6, IL-8, IL-12, TNFa