Cytokines

Question 1

IL-1 alpha and beta

Produced by

Answer 1

Macrophages

Epithelial Cells

Question 2

IL-2

Produced by

Answer 2

T cells (naive, Th0, and Th1 cells)

Question 3

IL-4 and IL-5

Produced by

Answer 3

Th2 cells

Mast cells

Question 4

Function of

IL-1

Answer 4

fever

Pro-inflammatory

Question 5

Function of

IL-4

Answer 5

Th2 differentiation
B cell activation
B cell switch to IgE

Question 6

Function of

IL-5

Answer 6

Promotes Eosinophilia

Question 7

IL-6

Produced by

Answer 7

Th2 cells
Macrophages
Endothelial cells

Question 8

Function of

IL-6 and IL-13

Answer 8

B and T cell growth
Acute phase protein production
Induce fever
Inhibits macrophages (IL-13, not IL-6)

Question 9

IL-7

Produced by

Answer 9

Stromal cells

Question 10

Function of

IL-7

Answer 10

Devo of B and T cell progenitors

Question 11

BAFF (Blys)

Produced by

Answer 11

B cells

Question 12

Function of BAFF (Blys)

Answer 12

B cell proliferation, maturation, survival

Question 13

IL-8

Produced by

Answer 13

Macrophages

Endothelial/ Epithelial cells

Question 14

Function of

IL-8

Answer 14

Chemotactic factor for neutrophils and other granulocytes

Question 15

IL-10

Produced by

Answer 15

Monocytes
T cells
Certain B cell subsets

Question 16

Function of

IL-10

Answer 16

Suppress macrophages and CTL

B cell growth factor

Question 17

IL-12

Produced by

Answer 17

Macrophages

Dendritic Cells

Question 18

Function of

IL-12

Answer 18

Th1 differentiation

Activates NK cells

Question 19

IL-13

Produced by

Answer 19

Th2 cells

Question 20

Function of

IL-17

Answer 20

Increase neutrophil production

Pro-inflammatory

Question 21

IL-22

Produced by

Answer 21

NK cells

Th17 cells

Question 22

Function of

IL-21

Answer 22

Proliferation of B, T, and NK cells

Question 23

Function of

IL-22

Answer 23

Induces acute phase proteins

Pro-inflammatory

Question 24

IL-23

Produced by

Answer 24

Dendritic cells

Monocytes/ Macrophages

Question 25

Function of | IL-23

Answer 25

Devo and proliferation of Th17 cells

Question 26

TNF-a | Produced by

Answer 26

Macrophages NK cells T cells

Question 27

Function of | TNF-a

Answer 27

Inflammation

Question 28

Lymphotoxin-a | Produced by

Answer 28

B and T cells

Question 29

Function of | Lymphotoxin-a

Answer 29

Induces apoptosis of target cells

Question 30

TGF-B1 | Produced by

Answer 30

Monocytes T cells Certain B cell subsets

Question 31

Function of | TGF-B1

Answer 31

Inhibits cell growth Anti-inflammatory Promotes IgA switch

Question 32

IFN-a | Produced by

Answer 32

all nucleated cells

Question 33

Function of | IFN-a and IFN-B

Answer 33

Anti-viral | Increases HLA Class I expression

Question 34

IFN-B | Produced by

Answer 34

Fibroblasts

Question 35

IFN-y | Produced by

Answer 35

T cells | NK cells

Question 36

Function of | IFN-y

Answer 36

Increases macrophage activation | HLA I and II expression

Question 37

IL-21 | Produced by

Answer 37

Th2 cells | Th17 cells