Cytokines (All) Flashcards by Heather Acuff

IL-7

Category
Secreted by / On surface of
Acts upon
Function

Development

Bone marrow and thymic stroma

B/T progenitors

B and T development

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IL-15

Category
Secreted by / On surface of
Acts upon
Function

Development

Bone marrow

NK progenitor

NK development

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IL-3

Category
Secreted by / On surface of
Acts upon
Function

Development

Bone marrow

Myeloid progenitor

Myeloid development

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G-CSF

Category
Secreted by / On surface of
Acts upon
Function

Development

Bone marrow

Neutrophil progenitor

Neutrophil development

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Erythropoietin (EPO)

Category
Secreted by / On surface of
Acts upon
Function

Development

Bone marrow

RBC progenitor

RBC development

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Mannose binding lectin

Category
Secreted by / On surface of
Acts upon
Function

Pathogen Recognition Receptor

Free protein in blood

Dense mannose/ fucose on pathogen

Opsonization, C’ activation

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Surfactant protein

Category
Secreted by / On surface of
Acts upon
Function

Pathogen Recognition Receptor

Free protein in blood

Pathogen

Opsonization, C’ activation

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Macrophage mannose R

Category
Secreted by / On surface of
Acts upon
Function

Pathogen Recognition Receptor

Macrophage surface

Dense mannose/ fucose on pathogen

Phagocytosis

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Scavenger R

Category
Secreted by / On surface of
Acts upon
Function

Pathogen Recognition Receptor

Phagocyte surface

Anionic polymers and acetyled LDL

Phagocytosis

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fMLP R

Category
Secreted by / On surface of
Acts upon
Function

Pathogen Recognition Receptor

Innate cell surface

fMet-Leu-Phe bacterial peptides

Innate cell secretion of CK

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TLR

Category
Secreted by / On surface of
Acts upon
Function

Pathogen Recognition Receptor

Surface and endosome

Bacterial / viral common patterns

Secretion of CK & chemokines, increase co-stimulatory molecules

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IL-1

Category
Secreted by / On surface of
Acts upon (2)
Function (2)

Pro-inflammatory

Macrophages, keratinocytes

(1) Lymphocytes
(2) Liver

(1) Enhances responses
(2) Induces acute phase protein (C-reactive protein and MBL) secretion

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IL-6

Category
Secreted by / On surface of
Acts upon (2)
Function (2)

Pro-inflammatory

Macrophages, DC

(1) Lymphocytes
(2) Liver

(1) Enhances responses, ↑Ab production
(2) Induces acute phase protein (C-reactive protein and MBL) secretion

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IL-8 (CXCL8)

Category
Secreted by / On surface of
Acts upon
Function

Pro-inflammatory

Macrophages, DC

Phagocytes

Chemoattractant for neutrophils, activates binding extravasation

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IL-12 (inflammatory)

Category
Secreted by / On surface of
Acts upon
Function

Pro-inflammatory

Macrophages, DC

Naïve T cells

TH1, pro-inflammatory, CK secretion

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TNFα

Category
Secreted by / On surface of
Acts upon
Function

Pro-inflammatory

Macrophages, DC

Endothelium

Extravasation changes; systemic can cause sepsis

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IFNα/β

Category
Secreted by / On surface of
Acts upon
Function

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Pro-inflammatory

Infected cell

NK cells

NK secretion of IFNγ, activate NK to kill, ↑MHC I

MHC I

Category
Secreted by / On surface of
Acts upon
Function

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Surface Molecule of APCs

All nucleated cells

CD8 T cells (CTL)

Killing of Ag-expressing infected cell

MHC II

Category
Secreted by / On surface of (2)
Acts upon
Function (2)

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Surface Molecule of APCs

(1) APC: DC, macrophages
(2) B cells

CD4 T cells

(1) T cell CK secretion to activate macrophages to increase phagocytosis
(2) T cell CK secretion to increase Ab secretion

B7-1 / B7-2 (aka CD80 / CD86)

Category
Secreted by / On surface of
Acts upon (2)
Function (2)

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Surface Molecule of APCs

APC

(1) CD28 (on T cells)
(2) CTLA4

(1) Co-stimulation of T cells
(2) Inhibit T cell activation

CD3, ζ

Category
Secreted by / On surface of
Function

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T Cell Accessory Molecule

T cell

Signal transduction of TCR complex

CD4 / CD8

Category
Secreted by / On surface of
Acts upon
Function

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T Cell Accessory Molecule

T cell

MHC II / I on APC

Adhesion and signal transduction

CD28

Category
Secreted by / On surface of
Acts upon
Function

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T Cell Accessory Molecule

T cell

B7-1/ B7-2 on APC

Signal transduction and co-stimulation

CTLA-4

Category
Secreted by / On surface of
Acts upon
Function

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T Cell Accessory Molecule

T cell

B7-1/ B7-2 on APC

Inhibitor of TCR transduction

CD40L Category Secreted by / On surface of Acts upon (2) Function (2)

T Cell Accessory Molecule T cell (1) CD40 on macrophages (2) CD40 on B cells (1) Activate macrophage (along with IFNγ and correct MHC + Ag) (2) Required for CD4 T dependent activation of B cells (along w/ MHC-Ag-TCR)

LFA-1 / VLA-4 Category Secreted by / On surface of Acts upon Function

T Cell Accessory Molecule T cell ICAM / VCAM on APC / endothelium Adhesion

IL-2 Category Secreted by / On surface of Acts upon (3) Function (3)

Adaptive Immune System CD4 and CD8 T (1) CD4 & CD8 T cells (2) B cells (3) NK cells (1) T cell growth stimulation (2) Increase Ab production (3) NK growth stimulation

IL-4 Category Secreted by / On surface of (2) Acts upon (2) Function (2)

Adaptive Immune System (1) APC (2) CD4 T cells, mast cells (1) CD4 T cells (2) B cells (1) Induces TH2 responses (2) Ig class switching to IgE

IL-5 Category Secreted by / On surface of (2) Acts upon (2) Function (2)

Adaptive Immune System (1) APC (2) CD4 T cells, mast cells (1) CD4 T cells (2) Eosinophils (1) Induces TH2 responses (2) Eosinophil activation

IL-12 (adaptive immunity) Category Secreted by / On surface of Acts upon (2) Function (2)

Adaptive Immune System DC (1) NK cells (2) CD4 T cells (1) Activates NK (DC-NK cross talk) (2) Induces TH1 responses

IFNγ Category Secreted by / On surface of (3) Acts upon (3) Function (3)

Adaptive Immune System (1) NK cells (2) CD4 TH1 cells (3) CD8 CTLs (1) DC (2) Macrophages; CD8 T cells (CTLs); B cells (3) Macrophages (1) Activates DC (DC-NK cross talk), steers DC to activate CD4 to Th1 response (2) Macrophage activation (also with CD40L to CD40 and correct MHC + Ag); Stimulate CTL activity; Stimulate C' activating Ab production (class switch to IgG1, IgG3) (3) Macrophage activation (also with CD40L to CD40 and correct MHC + Ag)

IL-17 Category Secreted by / On surface of Acts upon Function

Adaptive Immune System Th17 cells, some innate cells Innate cells, neutrophils Extracellular immunity (esp fungal infections), ↑neutrophil activity, bridges adaptive / innate

TGFβ Category Secreted by / On surface of (2) Acts upon (2) Function (2)

Adaptive Immune System (1) CD4 Tregs, many others (2) CD4 T cells (1) T cells (2) B cells (1) Inhibition of T cell activation, inhibits Th, CTL, NK (2) IgA class switch

IL-10 Category Secreted by / On surface of Acts upon Function

Adaptive Immune System CD4 Treg, many others T cells Inhibition of T cell activation, Th, CTL, NK

Igα/β (aka CD79a/b) Category Secreted by / On surface of Function

B Cell Accessory Molecule B cells BCR complex signal transduction

CD5 Category Secreted by / On surface of Function

B Cell Accessory Molecule B1 cells Surface marker (B2 cells are CD5-)

CD19 Category Secreted by / On surface of Function

B Cell Accessory Molecule B cells Surface markers from pro-B --> plasmablast

CD20 Category Secreted by / On surface of Function

B Cell Accessory Molecule B cells Surface marker from pre-B --> plasmablast

TLR4 Category Secreted by / On surface of Acts upon Function

B Cell Accessory Molecule B1 cells Lipopolysaccharide Polyclonal activation of B1 cells --> shortlived IgM secretion

CR2 Category Secreted by / On surface of Acts upon Function

B Cell Accessory Molecule B cells C3d deposited on pathogen C' activation B2 cells (along with BCR association with Ag on pathogen)

CD40 Category Secreted by / On surface of Acts upon Function

B Cell Accessory Molecule B cells CD40L on CD4 T Required for CD4 dependent activation of B cells (along w/ MHC-Ag-TCR)

Cytokines (All) Flashcards

(41 cards)