Cytokines, Chemokines, Igs And Adhesion Molecules Flashcards
(32 cards)
Primary inflammation
Activation of neutrophils
Induction of adhesion molecules
TNF
Thermoregulation/fever
Slow inflammation
IL-1
Produces INF-gamma from NK cells
IL-12
Major producer of APPs
Inflammation
IL-6
Not produced by macrophages but instead NK cells
Activates macrophages
INF-gamma
Lymphocyte/DC recruitment to HEVs
Control of inflammation (anti)
IL-10
Neutrophil recruitment
Conformational change in surface molecules for migration into tissue
IL-8 also known CxCL8
3 cytokines that work with proliferation of immunoglobins/T0cells and isotype switching
IL-2,4, and 5
Cytokine that associates with IgM
IL-2,4,5
Cytokine that that associates with IgE and IgG1
IL-4
Cytokine that associates with IgG3 and IgG2a
INF-gamma
Cytokine that associates with IgA and IgG2b
TGF-beta
Chemokine for monocyte recruitment
CCL2/MPC-1
Chemokine for T-cell, DC, NK monocyte recruitment
CCL4 (MIP-1beta)
2 chemokines for migration to parafillicular zones
CCL19 (MIP-3beta), CCL21 (SLC)
Chemokine serves as effector T-cell recruitment
Activates integrins and other chemokines
CxCL10 (IP-10)
Chemokine for hominv naive B-cells to LN
CxCL12 (SDF-1alphabeta)
Chemokine for B-cell migration and T-follicular helper cell migration into follicles
CxCL13 (BCA-1)
Immunoglobulin for neutralization in mucosal secretions; TGF-beta cytokine
IgA
Immunoglobulin complement activator; in plasma
IgM - default
Immunoglobulin B-cell receptor
IgD
Immunoglobulin that Penetrates deep tissue, works with complement and neutralization
IgG
Helminth defense/allergies and mast cell surfaces; IL4 cytokine
IgE
Peripheral selectin that acts by histamine and thrombin
P-selectin (CD62P)
