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Immunology (First Aid & Lecturio) > Cytokines in Adaptive Immunity > Flashcards

Cytokines in Adaptive Immunity Flashcards

1
Q

Typical size of cytokines

A

8-80 kDa (small)

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2
Q

Treg cells: effector response

A

Immune tolerance

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3
Q

Th1 cells: effector response

A

macrophages, intracellular pathogens

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4
Q

Th2 cells: effector response

A

humoral, IgE immunity

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5
Q

Th17: effector response

A

neutrophils, extracellular pathogens

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6
Q

Th22: effector response

A

skin protection, regeneration

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7
Q

Th9: effector response

A

tissue inflammation, mucus production

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8
Q

TFH: effector response

A

B cell maturation

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9
Q

Treg cells: characteristic cytokines

A

IL10, TGFbeta, IL35

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10
Q

Th1 cells: characteristic cytokines

A

IFNgamma, TNFalpha, IL2

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11
Q

Th2 cells: characteristic cytokines

A

IL4, 5, 13

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12
Q

Th9 cells: characteristic cytokines

A

IL 9, 10, 17, 21, 22

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13
Q

Th17 cells: characteristic cytokines

A

IL17, 21, 22, 23

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14
Q

Th22 cells: characteristic cytokines

A

IL 22

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15
Q

TFH cells: characteristic cytokines

A

IL 21

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16
Q

2 functions of cytokines

A

1) immune response

2) hematopoieisis

17
Q

Treg cells: dev triggering cytokine

A

IL10

18
Q

Th1 cells: dev triggering cytokine

A

IL12, IFNgamma

19
Q

Th2 cells: dev triggering cytokine

A

IL4

20
Q

TFH cells: dev triggering cytokine

A

IL6, 21

21
Q

Th22 cells: dev triggering cytokine

A

TGF beta, IL6

22
Q

Th9 cells: dev triggering cytokine

A

TGF beta, IL 4

23
Q

Th17 cells: dev triggering cytokine

A

TGF beta, IL6, 23

24
Q

2 types of interferons

A 
Type I (alpha & beta)
Type II (gamma)
25
Q

which cells make which interferons?

A

alpha: peripheral leukocytes (ie macrophages)
beta: fibroblasts
gamma: lymphocytes

26
Q

actions of IFNgamma

A

1) increases Th1 production, decreases Th2 production, activates macrophages
2) increases MHC I & II expression
3) blocks IgE class switching

Immunology (First Aid & Lecturio) (12 decks)

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