Cytokines, TH Pathways and Soluble Factors Flashcards
(24 cards)
Chemokines
- Adaptive Immune System
- Attract cells with appropiate receptors (CC or CXC)
TGF-B
T reg Pathway
- Produce TGF-B, IL-10
- Regulate anti-self responses
- CD4+, tolerogenic DCs
- Predominant in GALT
With IL-6
- TH 17 Pathway
- Produce IL-6, IL-17
- Recruit neutrophils
- Autoimmune damage
- Barrier integrity
- Fungi
IL-6
Inflammatory
With TGFB
- TH 17 Pathway
- Produce IL-6, IL-17
- Recruit neutrophils
- Autoimmune damage
- Barrier integrity
- Fungi
TFH Pathway
- Make IL-21
- Helps B cells
Produced by Th17
IL-12
Stimulatory
Th1
- Make IFNy, TNF
- Macrophages
- B cell help (IgG)
- Inflmmation
- Attack intra and extracellular bacteria
IL-33
Th2 (with IL-4)
- Produce IL-4, IL-5, IL-13
- Help B cells (IgE)
- Parasites
- Allergy
- Predominant in GALT
- Tolerogenic DCs
- Mast cells, eosinphil, plasma cells
IL-4
Th2 (with IL-33)
- Produce IL-4, IL-5, IL-13
- Help B cells (IgE)
- Parasites
- Allergy
- Predominant in GALT
- Tolerogenic DCs
- Mast cells, eosinphil, plasma cells
Produced by Th2
IL-10
Suppressive
Produced by Treg
- Regulate anti-self responses
- CD4+, tolerogenic DCs
- Predominant in GALT
IL-17
Produced by Th17
- Recruit neutrophils
- Autoimmune damage
- Barrier integrity
- Fungi
IFN-Y
Antiviral
Produced by Th1
- Macrophages
- B cell help (IgG)
- Inflammation
- Attack intra and extracellular bacteria
TNF
Inflammatory
Produced by Th1
- Macrophages
- B cell help (IgG)
- Inflammation
- Attack intra and extracellular bacteria
IL-5
Produced by Th2
- Help B cells (IgE)
- Parasites
- Allergy
- Predominant in GALT
- Tolerogenic DCs
- Mast cells, eosinphil, plasma cells
IL-21
Stimulatory
Produced by TFH
- Help B cells
T reg
Activated by
- TGFB
Produces
- TGFB
- IL-10
Response
- Regulate anti-self responses
- CD4+, tolerogenic DCs
- Predominant in GALT
TH 17
Activated by
- IL-6
- TGFB
Produces
- IL-17
- IL-6
Response
- Recruit neutrophils
- Autoimmune damage
- Barrier integrity
- Fungi
TH 1
Activated by
- IL-12
Produces
- IFNY, TNF
Response
- Macrophages
- B cell help (IgG)
- Inflammation
- Attack intra and extracellular bacteria
TH 2
Activated by
- IL-4, IL-33
Produces
- IL-4, IL-5, IL-13
Response
- Help B cells (IgE)
- Parasites
- Allergy
- Predominant in GALT
- Tolerogenic DCs
- Mast cells, eosinphil, plasma cells
TFH
Activated by
- IL-6
Produces
- IL-21
Response
- Help B cells
Lysozyme
Innate Immune System
- Disrupts peptidoglycan
C-reactive protein
Innate Immune System
- Binds capsule, aids phagocytosis, triggers complement cascade
Mannose binding lectin
Innate Immune System
- Binds mannose residues on pathogens, triggers the complement cascade
Complement proteins
Innate Immune System
- Pro-enzymes, bind pathogen, trigger cascade of reactions that generate effector molecules against pathogen
Classical Complement Pathway
Bind to antibody
Lectin Complement Pathway
Bind to mannan
Alternative Complement Pathway
Bind to pathogen surfaces
