D&D

Question 1

Histamine

Answer 1

Released by: mast cells, basophils, plats
Fxn: arterial dilation, endothelial contraction
Due to: 
   -Physical
   -Immune (binding of IgE)
   -Compliment (C3a, C5a)
   -Leuks histamine releasing proteins
   -Cytokines (IL1, IL8)

Question 2

Serotonin

Answer 2

In: plat granules
fxn: aid in clotting

Question 3

Arachidonic Acid metabolites

Answer 3

Source: leuks, mast, endothelium, plats
From cell membrane phospholipids
=Cmps that mediate inflam & hemostasis
2 activation pathways:
i. Cycooxygenase –> PG & TX
PG (vasodilation, stop plat aggregation)
Tx (vasoconstriction, increase plat aggregation
ii. Lipoxygenase –> leukotrienes, lipoxins
Leukotrienes (BV perm, leuk activation)
Lipoxins (X adhesion, anti-inflam)

Question 4

Cox1

Answer 4

• constitutive actions (always being produced)
• Plats: TXA2–> pro aggregation
• GI: PG–> ^ contractions, decrease acid secretion
• Kidneys: PG–> ^ renal blood flow (diuresis)
• BV smooth m: PG (dilation), TXA2 (constrict)