D7 Pharmaceutical Suspensions Flashcards Preview

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Flashcards in D7 Pharmaceutical Suspensions Deck (10)
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1

How is alginate a serendipitous product?

Originally designed for carrier of radiological contrast agent
- secondary discovery to relieve heartburn

2

If pH drops below 3.5 (the pKa of alginic acid) it will...

Precipitate as a gel

3

Function of carbonate or bicarbonate

Produces CO2 trapped in gel to produce a low density raft that can float on stomach contents and prevent stomach contents from refluxing into the oesophagus

4

Carbomer uses

Suspending agents, viscosity- increasing material

5

Parahydroxybenzoates (parabens) uses

Antimicrobial preservatives - longer chain esters have a greater antimicrobial activity

6

Sodium saccharin uses

300-600 times sweeter than sugar
Suitable for diabetics

7

Sodium hydroxide (NaOH) uses

Adjust the pH, at low pH values the alginate may precipitate; max viscosity pH 5-9
Increases pH to counter balance acidic carbomer lowering pH

8

Gaviscon _____ product for Peptac Liquid

Innovator

9

HDPE

High density polyethylene
- not impermeable to vapours

10

PET

Polyethylene terephthalate
-less permeable to oxygen than HDPE