Day 3 Patho Fast Review

Question 1

Stained using Sudan IV and Oil-Red-O?

Answer 1

Steatosis (Fatty Change)

Question 2

Biochemical Disorder in Heme synthesis presents with skin blisters due to photosensitivty?

Answer 2

Porphyria

Question 3

Most common variant of Porphyria? What enzyme is deficient?

Answer 3

Porphyria cutanea tarda due to deficent URO decarboxylase

Question 4

Which DMARD drugs may cause reactivation of latent TB?

Answer 4

Infliximab

Question 5

Only protein that undergoes final modification in the RER (not in Golgi Apparatus)?

Answer 5

Collagen

Question 6

Amplifies Platelet Aggregation leading to primary Hemostasis?

Answer 6

Thromboxane A2 (TXA2)

Question 7

Glycoprotein Iib-IIIa inhibitors?

Answer 7

Abciximab, eptifibatide, tirofiband and Glanzmann’s Thrombasthenia

Question 8

Lines of Zahn (laminations)?

Answer 8

Antemortem Thrombosis

Question 9

Libmanns Sacks Endocarditis occurs in?

Answer 9

SLE

Question 10

Most common casuse of native valve Endocarditis

Answer 10

viridans Streptococci

Question 11

Most common cause of Prosthetic valve endocarditis?

Answer 11

Staph. Epidermidis

Question 12

Which bacterium implicated in marantic endocarditis?

Answer 12

Streptococcus bovis

Question 13

most common ECG manifestation of Pulmo Embo?

Answer 13

Sinus Tachycardia

Question 14

Gold standary diagnosis of pulmo embo?

Answer 14

Pulmonary Angiography

Question 15

DVT that presents as a pale, painfule leg with a diminished arterial pulse due to vasospasm>

Answer 15

Phlegmasia alba dolens

Question 16

DVT that presents as a cyanotic, painful leg due to extensive thrombotic occlusion?

Answer 16

Phlegmasia cerulea doles

Question 17

Most severe form of Meningococcemia

Answer 17

Waterhouse-friderichsen syndrome (due to bilateral adrenal hemorrhage leading to adrenal insufficiency)

Question 18

Mutation in the gene encoding LDL receptor?

Answer 18

Familia Hypercholesterolemia

Question 19

Hexosaminadase alpha-subunit deficiency?

Answer 19

Tay-Sach Disease (GM2 Gangliosidosis)

Question 20

Predominant CNS and retinal involvement, Cherry Red Spot in the Macula?

Answer 20

Tay-Sach Disease (GM2 Gangliosidosis)

Question 21

Zebra bodies, massive splenomegaly and hepatomegaly, cherry red spot in the macula?

Answer 21

Niemann-Pick Disease

Question 22

Most common lysosomal storage disordr? Mutations in the Glucocerebrosidase?

Answer 22

Gaucher Disease

Question 23

(Mucopolysaccharidoses) Alpha-L-iduronidase defect (with corneal clouding, musculoskeletal abnormalities, CNS and CV problems)

Answer 23

Type 1 Hurler

Question 24

(Mucopolysaccharidoses) Iduronososulfate sulfatase with Musculoskeletal and CNS manifestations

Answer 24

Type 2 Hunter

Question 25

(Mucopolysaccharidoses) N-acetylgalactosamine 6-sulfatase deficiency with Corneal clouding, MS and CV manifestations

Answer 25

Type IV Morquio

Question 26

Balloon Cells (distended cells with apparent clearing of the cytoplasm); (+) Zebra bodies?

Answer 26

Mucopolysaccharidoses

Question 27

(Glycogen Storage Disease) Glucose-6-phosphatase deficiency; Severe hypoglycemia

Answer 27

Type 1 von Gierke

Question 28

(Glycogen Storage Disease) alpha-1,4-glucosidase def; with cardiomegalym muscle weaknessm death by 2 years

Answer 28

Type 2 Pompe

Question 29

(Glycogen Storage Disease) Glycogen Debranching Enzyme; mild hypoglycemia; liver enlargement

Answer 29

Type 3 Cori

Question 30

(Glycogen Storage Disease) Muscle glycogen phosphorylase; muscle craps and weakness on exercise

Answer 30

Type V McArdle

Question 31

First human inborn error of metabolism; black urin; Lack of Homogentistic Oxidase?

Answer 31

Alkaptonuria

Question 32

Most commonly associated with Rockerbottom feet? Edwards or Patau?

Answer 32

Patau

Question 33

Polydactyly, Cleft palate, holoprosencephaly?

Answer 33

Patau (Trisomy 13)

Question 34

Chrom 22q11.2 Deletion?

Answer 34

DiGeorge Syndrome

Question 35

CATCH 22 (Cardiac Defects, Abnormal Facies, Thymic Aplasia, Cleft Palate, Hypocalcemia, 22 q11.2 deletion)

Answer 35

DiGeorge

Question 36

lack of NADPH oxidase activity? Failure of oxidative burst?

Answer 36

Chronic Granulomatous Disease

Question 37

AR; failure of phagolysosomal fuion

Answer 37

Chediak-higashi Syndrome

Question 38

PSA Marker?

Answer 38

Prostate CA (may be eleveated in BPH and Prostatitis)

Question 39

Prostatic acid Phosphatase

Answer 39

Prostate CA

Question 40

CEA marker?

Answer 40

Colorectal and Pancreatic CA, Gastic CA and Breast CA

Question 41

AFP Marker?

Answer 41

Hepatocellular CA, Non-seminomatous GCS (yolk sac tumor)

Question 42

b-HCG

Answer 42

Hydatidiform more, choriocarcinoma, gestational trophoblastic tumor

Question 43

S-100

Answer 43

Melanoma, neural tumors, astrocytomas

Question 44

Alkaline Phosphatase

Answer 44

Mets to bone, obst. Biliary diseae, paget's disease of bone

Question 45

Bombesin marker?

Answer 45

Neuroblastoma, lung and gastric CA

Question 46

TRAO marker?

Answer 46

Hairy Cell Leukemia (B-cell neoplasm)

Question 47

CA 19-9 marker?

Answer 47

Pancreatic Adenocarcinoma