ddx Flashcards
(93 cards)
1
Q
photodist poikiloderma DDX
A
DMS/SLE/MCTD
photodrug(CCB-Telangiectasia),
TMEP, poikilodermatous MF
2
Q
photodist erythema
A
DMS/SLE( no heliotrope, sparing IP joints)/MCTD
MCTD, drug/photo/airborne contact dermatitis; photodermatoses
3
Q
nailfold capillary telangiectasia/erythema-
A
scleroderma, DMS
4
Q
Lichenoid papules over hands dorsum ddx
A
DMS
SLE, MRH(coral beeding),
xanthoma( yellowish hue)
5
Q
generalised sclerosing Ddx
A
1) scleroderma/drug induced(bleomycin, taxanes, vinyl chloride, silica)
2) scleromyxedema,poststrep Scleredema
3) CGVHD, PCT,NSF(absent facial/paraproteinemia),
6
Q
localised sclerotic Ddx - non facial , non linear
A
- morphea/extra genital lichen sclerosus/.cGVHD,
- eosinophilic fasciitis
- PCT
7
Q
localised sclerotic Ddx -facial
A
morphea
morpheic BCC, MAC(perineural, mets)
8
Q
localised sclerotic Ddx -linear
A
- linear morphea
2. atrophoderma of moulin(linear, blaschkoid),
9
Q
localised sclerotic Ddx -breast chest wall
A
- radiation dermatitis/cutaneous metS-ca en cuirasse/DFSP
2. morphea/extra genital lichen sclerosus/cGVHD,
10
Q
papular mucinosis-ddx
A
ddx papular GA/Sarcoid;
11
Q
scleromyxedema ddx
A
scleredema, leprosy, granulomatous dermatitis, disseminated GA, sarcoid, Lymphoma
12
Q
-LSA Ddx:
A
erosive LP /MMP/morphea/SA
13
Q
papulosquamous LP
A
-guttate psoriasis/lichen planus/P rosea/2 syphilis
14
Q
lichenoid papules -LP
A
lichen amyloidosis, papular mucinosis, lichenoid sarcoidosis/GVHD
15
Q
Pigmentation -LP
A
Lichen planus/pigmentosa/ prurigo pigmentosa(itchy)/lichenoid eruption/Peutz Jegher( hyperpigmented macules palms sole)
16
Q
Oral LP-
A
immunobullous, GVHD, SCC, concomitant malignancy
17
Q
Nail LP
A
GVHD,
18
Q
Warty verrucuous LP
A
I:hypertrophic DLE/LP/ poro; EB pruriginosa/EDV, atypical infx,eruptive KA/SCC
19
Q
blister + LP
A
pemphigoides(coexistant BP), bullous LP( within LP lesions, intense interface)
20
Q
PRP
A
DRESS, psoriasis, drug-induced psoriasiform , SCLE
21
Q
Acquired PPK
A
Drug-arsenic, arsenic,bleomycin,hydroxyurea,aquagenic, ; I-PRP/Reiter, TB, leprosy ;M-bazex,tripe palms,MF/hypothyroid, nutritional
22
Q
palmar pits:
A
D-arsenical I-pitted keratolysis I-punctata, punctate porokeratosis; M-Gorlin,,EDV,
G acropigmentation of Kitamura; Cowden ,Darier
23
Q
scaly figurate erythema
A
I: Annular psoriasis/ LP/porokeratosis
I:SCLE/ Sjogrens/
M:EGR
G: GA
24
Q
deep figurate erythema
A
deep EAC inflammatory morphea,tumid lupus
M: MF/pseudolymphoma
G:AEGGG, GA,
25
? Erosive figurate erythema
- IgA pemphigus vs SPD
| - LABD
26
repeated infx(molluscum, simplex, bacterial)+ eczema ?
1) immunodef-HIES,WAS, CGD
| 2) ?malignancy(CTCL):
27
shin/LL –
NLD ,pretibial myxedema
panniculitis/tumidLE/
morphea/scleroderma/scleromyxedema
28
itchy shin papules
1) perforating dermatoses/folliculitis/caclcinosis/GA
2) hypertrophic LP/pemphigoid nodularis(overlap)
3) EB pruriginosa
29
Perforating dermatoses:
inherited RPC;EPS,Kyrles(acquired)
30
upper back –
D:amyloidosis/scleredema/follicular mucinosis/REM/
| dermatomyositis/lupus mucinosis
31
Ear-
ALHE, kimura disease
32
Papulosquamous/pityriasiform
1) SCLE, PLC/parapsoriasis/MF
| 2) guttate psoriasis/secondary syphilis/PR(herald patch),
33
zosteriform-linear, dermatomal:
HSV/VZV,bullous ADR,Zosteriform mets
34
breast-
erysipelas, carcinoma erysipelatoides, lymphangioma circumscriptum
35
anetoderma- Ddx-
1.atrophoderma ,mid dermal elastolysis,papular elastorrhexis
2.post traumatic/infectious/acne scars
3.CTN/neurofibroma/ nevus lipomatosus superficialis
G: Goltz
36
a) multiple indurated yellowbrown plaques
G-NLD, NXG, GA; sarcoidosis,AMYLOID
| D-histiocytic(XG, xanthoma, PNH,RSD)
37
yellowish neoplasms-
sebacous/xanthoma/Xanthelesma/
histiocytic/amyloid,
BCC,
38
b)disseminated red brown Granulomatous:
granulomatous dermatitis, disseminated GA/scleromyxedema,sarcoid, lepromatous leprosy, /Lymphoma
39
c)discrete Multiple brown papules trunk-
eruptive spitz/DF/histiod leprosy/molluscum
histiocytosis: xanthoma-papular,eruptive(yellow) disseminatum, XG, GEH; mastocytosis
sarcoid; disseminated GA
40
face e)multiple brown papules -
histiocytic(generalised eruptive histiocytosis, cutaneous rosai dorfman(S100+,CD1a-) progressive nodular histiocytosis, XG, eruptive xanthoma ,XD)
syringomas, sarcoid
41
red brown plaques
(AGE?old-malignancy, multiple)
| inflammatory: tumid lupus, leprosy; sarcoid, histiocytes- XG, RDD mastocytoma; vasculitis granuloma faciale/EED
42
f)multiple facial papules-flesh colored
eruptive syringoma, sebcaeous neoplasms (Muirr torre syndrom) systemic amyloidosis
angiofibromas/collagenomas- TS
brooke spiegler-TE/Cylindroma/Spiradenoma
cowden(trichilemomma)
Fibrofolliculoma
43
g)grouped brown papules-
benign - segmental neurofibromatosis, agminated IDMN/Spitz, angiokeratoma/lichen aureus
44
h)acneiform- anticonvulsant,HE, iodide/bromide,
anticonvulsant,HE, iodide/bromide, EGFR inhibitor( cetuximab, erlotinib, gefitinib)- CLR/breast/pancreatic/nonsmall cell lung; papulopustular, tetracycline-responsive ,aw xerosis, brittle hair paroncyhia, PG
45
ddx massive LN+ brown papules:
cutaneous rosai dorfman Kikuchi’s, myeloproliferative, cutaneous mets
46
FACE/H+N
| Pustules/erosions-
Ofuji,ACD, PF, eczema herpeticum
47
FACE/H+N
| smooth Red plaque
( tumid lupus, sarcoidosis/Histiocytosis/lymphoma) vasculitis granuloma faciale/EED,
48
FACE/H+N follicular papules/pustules
eosinophilic follicultis
Ofuj
HIV(pruritic, truncal, papular)/hematologic malignancy assoc
49
head/neck flesh colored verrucuous plaque:
alopecia mucinosa idiopathic vs lymphoma associated(older, widespread)
Nevus sebaceous, epidermal nevus ,
50
periorbital granulomatous-
(LMDF) acne agminata, granulomatous rosacea, folliculotropic T cell lymphocytosis, micronodular sarcoid , eruptive syringoma
51
FACE Psoriasiform photodistributed plaque-
SCLE/DLE(annular, psoriasiform), facial discoid dermatosis, DLE like sarcoidosis GVHD
52
FACE/H+N
solitary ulcer/odd site-malignancy, infection,
bullous FDE, trigeminal trophic syndrome/artefacta(?lateral medullary syndrome
impaired somatic sensation, parestheisa, traumatic-relief, faulty sympathetic innervation,
fluoxetine erosive pustular dermatosis scalp),
53
granulomatous oral swelling :
| labial swelling??
OFG/TB/Sarcoid/crohn’s/Weg/Amyloid,Ascher’s TAS COW lip swells!
granulomatous rosacea/solid facial edema,angioedema/amyloidosis/ allergy(food, DTH dental metals)multiple mucosal neuromas: men2B-
54
papillomatous:oral swelling :
papillomatous:Verrucuous CA=oral florid papillomatosis;oral AN,
55
granulomatous nasal nodule
(? nasal obstruction/immunodef/recalcitrant)
-infection- TB* orificialis cutis, rhinoscleroma, mucocutaneous leishmaniasis,deep fungal-rhinosporidiosis, paracoccidio,sporo;atypical mycobacteria, syphilis*/leprosy* *upper airway granuloma; neoplastic- nodular SCC/KA, extranodal nasal NKT cell; Inflammatory: sarcoid, wegeners, churg strauss, rosai dorfman
56
Granulomatous erythematous papules(extra-facial):
papular GA/Sarcoid/xanthoma/RDD; infective granuloma(NTM); ALHE
57
Granulomatous dermatitis-
IGD/drug,patch/interstitial GA,sarcoid,
58
PNGD
papular GA perforating disorders,I: rheumatoid nodules/rheumatoid nodulosis/subcutaneous GA
59
GA
| follicular papules/dyskeratinization
Follicular atrophoderma- KP atrophicans spectrum HV, atrophia maculosa varioliformis cutis, erythromelanosis facei, KP ,trichodysplasia spinulosa
60
keratosis folliculitis spinulosa decalvans
lichen spinulosus, lichen nitidus(like PMLE/sarcoid), lichen syphilliticum
61
LPP graham little syndrome
KP ; Grovers Dariers, flegel’s,GVHD
62
Solitary scaly plaque-
bowen’s, hidroacanthoma simplex, sbcc
63
Warty verrucuous –
I:hypertrophic DLE/LP/porokeratosis
infective- EDV, HPV, mycobacterial deep fungal,
malignant: eruptive KA/SCC,
G- EB pruriginosa
64
Generalised verrucosis:
EDV, HIV organ transplant SCID
65
localised verrucuous/follicular hyperkeratosis+-blashkoid
Porokeratotic eccrine ostial and dermal duct nevus/
nevus comedonicus(dilated follicular ostia cornified)/
milia en plaque
epidermal nevus
66
Calcinosis-dystrophic-(dermis/subcutis/absent organ)
iatrogenic/trauma/neoplasm-cyst,pilomatricoma, CTD, LE/CCLE, morphea, scleroderma, CREST, juvenile dermatomyosistis; metastatic(+organ involvement-hypercalcemia/phosphatemia,CRF, Albright’s hereditary osteodystrophy-shortened 4/5th MC, short stature); idiopathic- calcinosis scroti
67
Hyperpigmentation drugs
drugs- AM; amiodarone
chemo(busulfan, cyP,hydroxyurea);
mino;metals;
endocrine
68
diffuse slate gray sun exposed-
amiodarone,antimalarial
psychotropic-
metals Ag,Me, gold
69
redbrown
clofazamine(drug in fat); Addisons/cushings; arsenic(guttate leukoderma)
70
blue-black
minocycline,clofazimine(lesional); AM
71
Hyperpigmentation
drugs- FDE
erythema dyschromicum perstans:
LPP:
72
axilla/groin annular circinate vesicopustules -
Sneddon wilkinson’s- IgA pemphigus-herpetiform pemphigus ,
LABD, DH
pustular psoriasis,
73
Raynaud’s-
physical- cold, vibration, drug, CTD- DMS, SLE, overlap, cryoglobulinemia, Buergers, thoracic outlet
74
Posterior neck induration-
scleredema/nuchal fibroma
75
multiple brown patches plaque
- cutaneous plasmacytosis/benign pretibial lymphoplasmacytic infiltrate
76
(shoulder plaque)
Leiomyoma/connective tissue nevus/DFSP/dermatomyofibroma
77
special sites: intertriginous
SDRIFE-
| TEC -Eccrine squamous syringometaplasia
78
warty/vegetative,fisurred/erosive?: intertriginous
hailey hailey,PV,
| inverse psoriasis, darier’s
79
seborrheic distribution (V-back),
PF, Dariers, SCLE,
80
ORAL GENITAL SYNDROMES: + OCULAR
erosive LP,LP syndrome-vulvovaginal gingival; immunobullous(MMP, PV); reiter’s
81
Erosive genital/perineal plaque: inflammatory/malignancy
LSA+SCC/bowens/empd???leukoplakia
82
genital growths
Sclerosing FB lipogranuloma
| I:premalignant- HPV, Condyloma acuminata, Bowenoid papulosis N:Erythroplasia queyrat, Verrucuous carcinoma
83
genital annular
GA, circinate balanitis Reiter’s :
84
genital erosions
bullous/ erosion FDE, pemphigus, papular acantholytic dyskeratosis, hailey hailey, PG/Crohns
infectious-syphillitic chancre, TB, Leishmaniasis
85
grouped small angiomatous vascular lesions
angioma,angiokeratoma
| Unilateraral nevoid telangiectasia /angioma serpiginosum
86
multiple/solitary larger vascular,
glomangioma, glomeruloid hemangioma/cherry angioma
| Glomus tumor- glomuvenous malformation
87
scalp red nodule
angiosarcoma ddx hemangioendothelioma
| AFX, melanoma, BCC/SCC
88
KS
KS:acroangiodermatits,
| angiolupoid sarcoid
89
Ddx- ALM,
talon noir-trauma, minute black dots, spindle cell nevus of reed
90
multiple nevi
in transit melanoma mets, Eruptive DF- CTD eruptive spitz,
91
multiple NMSC
1.chronic arsenicism/Radiation/-drug-induced-Organ transplant
2. Immunosuppressed
lymphoma/HIV, EDV-3,5,8,10,47
3.Xeroderma pigmentosum/ EDV/Naevoid BCC syndrome/ Bazex’s Rombo syndrome
92
Gorlin:
ddx Rombo- BCC, TE, milia
93
EMPD
Bowens, supf BCC, MIS
