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Flashcards in deck_524014 Deck (130)
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2

review of structure of paramyxoviruses- enveloped?- nucleocapsid symmetry?- genome structure?- -/+ stranded?

enveloped virionhelical symmetrygenome consists of a single molecule of RNARNA genome is minus-stranded

3

what type of virus are mumps and measles?

paramyxoviruses

4

are mumps and measles antigenically related to parainfluenza viruses?

mumps ismeasles is not

5

describe mumps and measles:- nucleocapsid- genome- +/-- envelope?

helical nucleocapsidminus-stranded RNAenvelope with virus-specified glycoproteins

6

do mumps and measles hemagglutinate red cells?

yes

7

do paramyxoviruses carry an RNA polymerase?

yes

8

can measles and mumps viruses reassort? why or why not?

since the RNA is only one piece, genetic reassortment is impossibleas a result, no significant antigenic variation has been seen

9

what types of infections do mumps and measles (and paramyxoviruses) cause?

systemic infections with viremia as an essential step in pathogenesis

10

what is an essential step in the pathogenesis of mumps and measles

viremia

11

what kinds of infections do orthomyxoviruses and paramyxoviruses generally cause?

local, nonsystemic noviremic infections

12

what is the significance of the fact that mumps and measles cause systemic infection (summary)?

incubation period is longer for mumps and measles because cycles of multiplication in several sites in sucession are requiredlifelong immunity occurs in individuals who have had the disease - obligatory viremia allows neutralization by IgG

13

how does the incubation period of mumps and measles compare with that of orthomyxoviruses and paramyxoviruses (so flu and paraflu)?

it's longer because the cycles of multiplication is several sites in succession are required to establish infection in mumps and measles

14

how long is immunity to mumps and measles after infection?

lifelong

15

what antibody type is involved in the reaction to mumps and measles?

obligatory viremia allows for neutralization by IgG

16

how many serotypes of mumps are there?

only one

17

how many types of species can mumps infect?

humans are the sole reservoir of mumps

18

how is mumps transmitted?

by respiratory droplets

19

how long is the average incubation period of mumps before symptoms appear?

18 days

20

what are the symptoms of mumps? what would allow you to diagnose mumps (ie what would you look for)?

around 18 days, a prodromal period of fever, malaise, and anorexia is followed by unilateral or bilateral swelling of the parotid gland (parotiditis) = usual presenting clinical symptomwill have inflamed parotid duct (stensens duct) in mouthalso get orchitis in males after age of puberty

21

what is paratiditis

caused by mumpsinfection of the parotid glandthe virus grows in the enlarged parotid salivary glands becomes painfulis excreted in saliva several days before and after swelling of the gland begins

22

why does mumps cause pain?

pressure and swelling within organs in tight capusles, so ones like the parotid gland and testis (orchitis) after puberty

23

are most mumps infections symptomatic or asymptomatic?

most are symptomatic - only 30% are subclinical/asymptomatic

24

where does mumps virus multiply, primarily?

in respiratory epithelium and local lymph nodes

25

what is the result of primary mumps multiplicaton (ie what's the secondary step in infection)?

in viremia that spreads to the salivary glands and other organs

26

where do most of the infectious virions in mumps come from?

they are produced in the salivary glandsthey go down the duct to the mouth and are spread by coughs and sneezes

27

how long does it take for parotiditis to begin in a mumps infection?

about 18-21 days = a three week incubation period

28

how frequent is orchitis in mumps infections?

occurs in about 30% of infected males past puberty

29

what is orchitis?does it resolve?who can get it?

painful inflammation of the testiclescaused by mumpsunilateral orchitis resolves with no other complicatoinsbilateral can result in sterility or subfertility but this outcome is uncommononly in adults after puberty because children don't have fibrous capsule yet

30

what organs are affected by mumps?

testicles, parotid glanduncommonly the pancrease and ovarymore commonly the meninges (aseptic meningitis)all have a generally benign course

31

how long is the immunity to mumps after infection?

generally lifelong, even after subclinical infection