Defensive Failure and the Bone Marrow Flashcards
What are the 3 main types of immunodeficiency?
Congenital, acquired, and iatrogenic
How common is congenital immunodeficiency?
Rare
What specificly can be deficient in congenital immunodeficiency?
B cells, T cells, Combined, neutrophils
What specificly can be deficient in acquired immunodeficiency?
B cells, T cells, B and T cells, neutrophils
Give an example of congenital B cell deficiency.
X linked hypogammaglobulinaemia
Give an example of congenital T cell deficiency.
Di George Syndrome
What is SCID?
Severe combined immunodeficiency - recessive condition characterised by low T and B cells.
How is SCID treated?
Bone marrow transplant
What is ataxia telangiectasia?
Recessive immunodeficiency characterised by thymic hypoplasia and low B cells.
How is ataxia telangiectasia treated?
Bone marrow transplant
Give an example of a congenital neutrophil deficiency.
Chronic granulomatous disease
Tell me about chronic granulomatous disease.
X linked recessive characterised by persistent infection of skin/resp tract/GI tract. Treated with bone marrow transplant.
What can cause an acquired B cell immunodeficiency?
Chronic lymphatic leukaemia
Other lymphoproliferative disorders
Myeloma
Nephrotic syndrome
What can cause an acquired T cell immunodeficiency?
HIV
Chemotherapy
Hodgkin’s disease
Immunosuppression
What can cause a B and T cell deficiency?
Radiotherapy
CLL
Malnutrition
