Deja Review - Biochemistry I Flashcards Preview

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Flashcards in Deja Review - Biochemistry I Deck (47):
1

ELISA

determine presence of Ab or Ag in test sample

2

cell concentrations of lytes

K - intracellular
Na and Ca - extracellular

3

crumpled tissue paper cells

gaucher disease

4

vit A defciency

ocular abnormal
night blindness
keratomalacia - soft cornea

squamous metaplasia of resp tract

5

vit A in eye

11-cis to all trans - with light

vit A - regenerate rod cell rhodopsin - 11-cis

6

beta-carotene

precursor to vit A

7

deficient vit E

erythrocyte fragile - hemolysis

8

vit D from sun

cholecalciferol - D3

9

vit D from milk

ergocalciferol - D2

10

confabulation

exaggerated lying story

with wernicke-korsakoff

hemorrhagic lesion - maxillary bodies and paramedian gray mater

11

dry and wet beriberi

thiamine - B1 deficiency

dry - dilated cardiomyopathy
wet - polyneuropathy

12

pathways with B1 cofactor

oxidative carboxylation a-ketoacids
transketolase in HMP shunt

13

measure of B1 deficiency

transketolase activity in RBCs

14

riboflavin

vit B2

FAD and FMN

15

niacin

vit B3

NAD and NADP

reduction and oxidation reactions

16

hartnup disease

get B3 deficiency

inadequate tryptophan absorption in gut and renal tubules

17

B3 deficiency in carcinoid

because tryptophan being used to synthesize serotonin instead of niacin

18

function of B5

panthenoic acid - CoA

for fatty acid synthesis

19

sups with isoniazid

need B6

20

pathways use B6

GABA production
transaminoation cofactor
decarboxylation cofactor

21

cobalamin

B12

22

B12 deficient in japanese immigratn

diphyllobothrium datum
-fish tapeworm

23

test localize B12 deficiency cause

shilling test

24

require folic acid pathways

synthesis of nitrogenous bases - purines and thymine

25

biotin

vit B7

26

pathways used B12

homocysteine methylation to methionine

27

menke disease

copper deficiency
-X-linked disease

kinky haur and mental retardation

28

tx cyanide poisoning

thiosulfate
hydroxocobalamin

29

CCl4 exposure

centrilobular necrosis and fatty change of liver

30

tx ethylene glycol toxicity

fomepizole
ethano

31

lead toxicity anemia

hypochromic microcytic

decreases heme synthesis

32

lead inhibits what enzymes

d-ALA dehydratase
ferrochelatase

33

fanconi syndrome

impaired renal absorption of AA, glucose, and P

association with lead toxicity

34

tx lead poisoning

succimer
penicillamine
EDTA
dimercaprol

35

antidote B-block

glucagon

36

antidote TCA

sodium bicarb

37

antidote quinidine

sodium bicarb

38

gingival hyperplasia, hirsutism, folate deficiency

phenytoin

39

severe flushing with lipid agent

niacin

40

lupus like syndrome drugs

hydralazine
INH
procainamide
phenytoin

41

photosensitivity rxns drugs

sulfonamides
amiodarone
tetracycline

42

agranulocytosis drugs

clozapine
carbamazepine
colchicine

43

drugs with gynecomastia

spironolactone
digitalis
cimetidine
estrogen
ketoconazole

44

fructose intolerance

hypoglycemia, jaundices, cirrhosis

increased fructose 1-P

decreased phosphate

aldolase B deficient

45

avoid with hereditary fructose intolerance

fructose and sucrose

46

asymptomatic with fructose in urine

essential fructosuria

deficient - fructokinase

47

genetic of fructose intolerance

auto recessive