Delivery of proteins: vaccines and monoclonal antibodies Flashcards Preview

PM3B: Autumn > Delivery of proteins: vaccines and monoclonal antibodies > Flashcards

Flashcards in Delivery of proteins: vaccines and monoclonal antibodies Deck (5)
Loading flashcards...
1
Q

What are the two main classes of polypeptides

A
  1. Proteins and peptides

2. Monoclonal antibodies

2
Q

What are the three different vaccine types and give examples of each of them

A

Live attenuated: polio, BCG, typhoid fever

Killed: influenza

Subunit: Hepatitis B, tetanus toxin, typhoid fever

3
Q

Describe the four different compositions of vaccines

A
  1. Antigen- what the immune response generates to and protects from infection
    Example: Whole organism
  2. Adjuvant- promotes an immune response to drive inflammation
    Example: ALUM (aluminimum salts)
  3. Stabilisers- prevents physical or chemical degradation of antigen
    Example: Polysorbates
  4. Preservatives
    Prevents microbial growth
    Example: Formaldehyde
4
Q

How are vaccines normally delivered via which route

A

Intramuscular injection

Oral

5
Q

What are the formulation challenges involved with vaccines

A

Stability: complex bio macromolecule formation

Multiple doses required

Minimal interactions possible to create multivalent doses