Dementia Flashcards

(72 cards)

1
Q

______ term memory is more affected than _____ term memory

A

short term more affected than long term

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2
Q

What part of the brain handles short-term memory? What are the changes w/ age?

A
  • prefrontal cortex

- stable, but may require more effort to encode before decay

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3
Q

What type of memory stays the longest w/ Alzheimer’s?

A

Procedural memory - stuff you do subconsciously

- implicit

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4
Q

What type of memory is most affected by Alzheimer’s? Why?

A

Explicit (declarative) episodic - autobiographical of events, contextual knowledge, and associated emotions
- occurs in hippocampus which is diminished in Alzheimer’s

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5
Q

Delirium vs Dementia onset

A

Delirium - temporary and has rapid onset

Dementia - slow progression and gradually

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6
Q

Delirium vs Dementia duration

A

Delirium - duration is only as long as the cause of the issue

Dementia - chronic, progressive continuation

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7
Q

Delirium vs Dementia attention

A

both have issues with attention but cleared up after delirium ends and does not with dementia

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8
Q

Delirium vs Dementia consciousness

A

Delirium - has issues w/consciousness

Dementia - there is no issue until the end

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9
Q

Delirium vs Dementia speech

A

Delirium - gargled speech, hallucinations

Dementia - continuum depending on the stage of dementia
- early on anomia - difficulty w/ word finding

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10
Q

What is also common alongside of Alzheimer’s disease?

A

depression - hard for the patient to verbalize sadness and other feelings of depression

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11
Q

What is pseudodementia? What helps patient with this?

A

apparent intellectual decline that stems from lack of energy or effort
- responds well to depression treatment

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12
Q

Difference between pseudodementia from dementia

A
  • more rapid decline in mental function
  • usually not disoriented
  • difficulty w/ concentrating but less difficulty w/ short term memory
  • writing, speaking, and motor skills usually not affected
  • more likely to comment on memory problems
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13
Q

T/F: Writing, speaking, and motor skills are usually not affected w/ pseudodementia

A

true - they are affected w/ dementia

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14
Q

Depression more common in _____ to ______ stages of dementia

A

early to moderate

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15
Q

Increased severity of dementia = ________ prevalence of major depression

A

decreased

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16
Q

Amnestic vs nonamnestic cognitive impairment

A

Amnestic - memory is impaired but other cognitive functions are spared (prestage of dementia)

Nonamnestic - memory remains intact, but 1 or more other cognitive abilities are significantly impaired

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17
Q

What level of cognitive impairment does the following pt have: pt feels like their memory is slipping but testing is normal

A

Subjective cognitive impairment (SCI)

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18
Q

What level of cognitive impairment does the following pt have: testing/outcome measure shows change but not severe enough for dementia

A

Mild cognitive impairment

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19
Q

What level of cognitive impairment does the following pt have: can take care of themselves for the most part - need spouse w/ them or may live in assisted living

A

Mild dementia

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20
Q

Difference between mild cognitive impairment and mild dementia

A

MCI pt can still take care of themselves at home and mild dementia needs some assistance/supervision w/ ADLs

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21
Q

What level of cognitive impairment does the following pt have: need help w/ ADLs and lots of word finding issues

A

moderate dementia

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22
Q

What level of cognitive impairment does the following pt have: wheelchair/bed bound, may be non-verbal and need full time care

A

severe dementia

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23
Q

What is vascular dementia caused by?

A

Caused from stroke, atherosclerosis, diabetes, HTN, smoking – anything that inhibits blood flow to the brain

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24
Q

Vascular dementia key features

A
  • abrupt most often
  • memory loss usually less severe than Alzheimer’s
  • mood changes and apathy common
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25
clinical symptoms of vascular dementia
- impaired attention, planning - difficulties w/ complex activities - disorganized thought
26
What type of dementia is associated w/ complex visual hallucinations? Why?
Lewy Bodies Dementia | - temporal and occipital lobes are affected
27
Key features to Lewy Bodies Dementia
- complex visual hallucinations - parkinsonism - sleep disturbances - autonomic symptoms (HTN) - fluctuating cognition
28
What type of dementia can be in conjunction w/ Parkinson's?
Lewy Body Dementia
29
Key features of frontotemporal dementia
- younger groups - 50-60 y/o - memory in tact in early stage - significant changes in behavior and personality - disinhibition and impulsiveness are common
30
________ and _________ is more affected in frontotemporal dementia compared to other types of dementia.
Behavior and executive function
31
What type of behavior do frontotemporal dementia patients have?
disinhibition and impulsiveness
32
Key features of Alzheimer's disease
- gradual loss of memory and function leading to dependence on caregivers - eventual inability to recognize family/friends/self
33
diagnostic markers for Alzheimer's disease. | - How many have to be present?
- medial temporal atrophy - temporoparietal hypometabolism - abnormal neuronal CSF markers (tau and/or Abeta) only 1 of 3 must be present
34
Which areas of the brain are most affected by dementia, specifically AD?
memory and language
35
What builds up in between neurons in Alzheimer's patients?
amyloid plaques that block signal transmission that leads to cell death
36
What biomarkers are used to determine Alzheimer's? Where are they found?
- AB42 - tau - p-tau all in CSF
37
T/F: High level of amyloids are less likely to have tumor and vice versa
true
38
What appears to be driving force behind AD?
Beta amyloid
39
Why are drug trials not showing patient improvement in AD?
by the time the patient shows symptoms, amyloid accumulation is at the peak and the drugs can only slow further progression - by the time the drug is given there is simply too much damage done
40
What is APOE? What is the lowest and what is the highest?
- genetic marker for chance to develop AD APO2 – linked with lowest risk of Alzheimer’s APO4 – highest risk - Everyone has 2 of some combination (2 alleles)
41
What type of medication would you want for someone w/ AD?
acetylcholinesterase - want something to block the break down of Ach
42
What are the 3 types of memory?
- Short-term memory- Registration - Working memory- Processing - Long-term memory- Storage and retrieval
43
What is the Zarit Burden scale?
survey to see caregiver burn out
44
What is the functional assessment staging (FAST) scale used for?
describe the stages of dementia | - stages 1 (normal adult) - 7 (severe AD)
45
What is Blessed and Short Blessed testing for?
memory and concentration test
46
What is the dementia screening indicator?
simple screening tool that can be used in primary care setting
47
What types of questions are on the functional activities questionnaire? Is it short or long?
- bill paying, tracking current events, transportation questions - short test that provides greatest diagnostic utility
48
What is the geriatric depression scale? How long is it?
- self report yes/no questionnaire to identify depression | - long form has 30 questions and short form has 15
49
What is the global deterioration scale? How is it completed?
7 stages to characterize where an individual is at in the dementia disease process (done through observation)
50
Mini-Cog consists of what tests?
3-step assessment: - 3-word registration - clock drawing - 3-word recall
51
What are the 5 areas of cognitive function?
- orientation - registration - attention and calculation - recall - language
52
What is the mini mental state exam (MMSE)?
11 question measure that tests 5 areas of cognitive function - orientation - registration - attention and calculation - recall - language
53
Clinical Dementia Rating (CDR) 0
no cognitive impairment
54
Clinical Dementia Rating (CDR) 0.5
very mild cognitive impairment (MCI)
55
Clinical Dementia Rating (CDR) 1
mild dementia
56
Clinical Dementia Rating (CDR) 2
moderate dementia
57
Clinical Dementia Rating (CDR) 3
severe dementia
58
What does Montreal cognitive assessment (MoCA) evaluate?
- 30 question test - orientation - short term memory - executive function/visuospatial ability - language abilities - animal naming - abstraction - attention - clock-drawing
59
Which test has clock drawing?
MoCA and Mini-Cog
60
What is the Trail making test used to assess?
- executive function - visual search - scanning - speed of processing - mental flexibility
61
What test uses the task of sewing stitches to evaluate cognition?
Allen Cognitive Level Screen (ACLS) | - Measures global cognitive processing abilities through observation of activity performance
62
3 tips for selecting the appropriate test to use on someone w/ cognitive impairments
- short instructions w/ no more than 3 steps - short test duration to avoid fatigue - select tests based on goal (balance, activity tolerance, etc.)
63
The 6 min walk test has good to excellent test-retest reliability w/ what type of patients? What is 1 downside?
mild to moderate dementia and mild to severe dementia | - there is a large MDC
64
What does repeated chair stand test test for?
LE strength/power and fall risk
65
What are the 3 parts of the short physical performance battery?
- balance - gait speed - 5x sit to stand
66
Who is the miniBESTest most appropriate for?
MCI and early stages of dementia
67
What measures dynamic walking ability by walking over meandering curved line with emphasis on walking speed and stepping accuracy while changing directions
Groningen Meander walking test
68
What type of dementia has the slowest gait speed? Why?
- frontotemporal dementia | - due to frontal lobe involvement
69
What can be a precursor to cognitive issues due to impact on the hippocampus?
HTN - associated w/ white matter disease and atrophy
70
What type of exercise is beneficial for executive functions?
aerobic activities
71
What reduced gait variability during dual task in both healthy subjects and those with PD – Parkinson’s?
tai chi | - rhythmic auditory cueing (RAS) reduced gait variability in patients w/ PD
72
What are the 6 domains of balance?
- biomechanical constraints - stability limits/verticality - anticipatory postural adjustments - postural responses - sensory orientation - stability in gait