Dementia Flashcards
(9 cards)
1
Q
what is dementia?
A
a progressive and largely irreversible clinical syndrome characterised by impairment of mental function
2
Q
what are the different types of dementia?
A
- alzheimer’s disease
- vascular dementia
- dementia with lewy bodies
- mixed dementia
- frontotemporal dementia
3
Q
dementia aims of treatment
A
- promote independence
- maintain function
- manage symptoms of dementia
4
Q
what is first line treatment of dementia?
A
acetylcholinesterase inhibitors
5
Q
acetylcholinesterase inhibitors MOA
A
AChE inhibitors stop the enzyme AChE from breaking down ACh into acetate and choline. This causes ACh to build up in the synapse, which activates cholinergic receptors
6
Q
examples of ach esterase inhibitors
A
- donepezil
- galantamine
- rivastigmine
7
Q
Dementia add on therapy
A
- glutamate receptor antagonist (memantine)
8
Q
what type of dementia are ach esterase inhibitors and memantine not recommended
A
frontotemporal dementia
9
Q
MHRA warning dementia
A
increased risk of stroke and death when antipsychotics are used in elderly patients with dementia
