Depression Flashcards

(58 cards)

1
Q

What are the core features of depression?

A

Depressed mood
Loss of interest (anhedonia)
Lack of energy (anergia)

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2
Q

What are additional symptoms of depression?

A

Loss of confidence/senf-esteem
Unreasonable feelings of self-reproach or excessive guilt
Recurrent thoughts of death or suicide
Decreased ability to think or concentrate, indecisiveness
Change in psychomotor activity - agitation or retardation
Bleak and pessimistic views of the future
Sleep disturbance
Change in appetite and corresponding weight change

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3
Q

What is psychomotor retardation?

A

Slowing of thoughts and reduction of physical movements, speech and affect

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4
Q

How are appearance and behaviour altered in depression?

A

Reduced eye contact
Reduced facial expression
Limited gesturing (psychomotor retardation)
Difficult to establish rapport

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5
Q

Describe speech in depression

A

Slow
Lowered in pitch
Quiet
Monotonous (reduced intonation)
Increased latencies (longer time between end of a question and them starting to speak)
Limited content (answers are often short, brief, and unembellished)

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6
Q

Describe mood in depression

A

Low, down, miserable, unhappy, sad, flat, empty, black, numb

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7
Q

Describe affect in depression

A

Reduced range - stays low throughout

Limited reactivity

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8
Q

Describe thoughts in depression

A

Form - normal
Flow - slow
Content
- Negative, failure, guilt, low self esteem, pessimism
- Delusions - of poverty, nihilism, hypochondriasis
- Suicidal thinking

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9
Q

Describe perception in depression

A

Most have no perceptual disturbance
Increased self-referential thinking (people are talking about me)
Hallucinations (usually auditory, second person and derogatory, negative and depression)

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10
Q

Describe cognition in depression

A

Slow
Poor memory (inattention)
‘Pseudo-dementia’
Deficits in working memory, attention and planning

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11
Q

Describe insight in depression

A

Insight preserved
Aware of their symptoms - recognition intact
Attribution not always correct - symptoms can be blamed on sins, physical illness, personal failings

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12
Q

What are the subtypes of depression?

A

Somatic syndrome
Atypical depression
Psychotic depression
Chronic depression

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13
Q

What is somatic syndrome?

A

4 of the following present:

  • Marked loss of interest or pleasure in activities that are normally pleasurable
  • Lack of emotional reactions to events or activities that normally produce an emotional response
  • Waking in the morning 2 hours before the usual time (early morning wakening)
  • Depression worse in the morning
  • Objective evidence of marked psychomotor retardation or agitation (remarked on or reported by others)
  • Marked loss of appetite
  • Weight loss (5% or more of body weight in the past month)
  • Marked loss of libido
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14
Q

What is atypical depression?

A

Mood reactivity - mood brightens in response to actual/potential positive events
Weight gain or increase in appetite
Hypersomnia
Leaden paralysis - heavy feeling in arms or legs
Long-standing pattern of interpersonal rejection sensitivity

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15
Q

What is psychotic depression?

A

Depression with psychotic features

Occasionally paranoid

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16
Q

What is chronic depression?

A

2 years of depression

Not necessarily treatment refractory

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17
Q

What is the medical differential of depression?

A
Hypothyroidism
Cushing's
Syphilis
SLE
Drugs: steroids, isotretinoin, B blockers
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18
Q

What are the psychiatric differentials of depression?

A
Bipolar
Schizophrenia
Generalised anxiety disorder
Substance misuse
Dementia
Dysthymia
Bereavement reaction
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19
Q

How would you differentiate depression from bipolar disorder?

A

Have you ever had periods of the opposite where your mood has been very high?

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20
Q

How would you differentiate depression from schizophrenia?

A

Have you ever experienced anything (seeing or hearing) that others haven’t or had thoughts that seemed unusual but you weren’t able to shake?

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21
Q

How would you differentiate depression from generalised anxiety disorder?

A

Do you feel yourself anxious, any physical symptoms of anxiety?

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22
Q

What is dysthymia?

A

Chronic mild depression for a minimum of 2 years in which episodes are either not long enough or severe enough to meet criteria for depression

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23
Q

What is the criteria for depression?

A

Symptoms for minimum 2 weeks

Presence of at least 2 of the core symptoms

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24
Q

What is classed as mild depression?

A

2 core symptoms + 2 additional symptoms

In distress but able to continue with activities of daily living

25
What is classed as moderate depression?
2 core symptoms + 4 additional symptoms | Associated difficulty in carrying out activities of daily living
26
What is classed as severe depression?
3 core symptoms + 5 additional symptoms Associated with hopelessness, worthlessness, suicidal ideation, somatic symptoms and complete inability to carry out activities of daily living
27
What is the management of depression?
Reassure the patient that in time, mood will get better Self-supportive measures (self-help, talk to people, exercise, activities you used to enjoy) CBT Antidepressants ECT
28
How long should antidepressants be continued for? (for a first episode, and subsequent episodes)
First episode - at least 6 months after full recovery w/o reducing dose Second+ episode - at least 1-2 years after full recovery w/o reducing dose May be needed lifelong
29
When is ECT used?
Life-saving or very treatment resistant cases | When a quicker response than anti-depressants can offer is needed
30
What are the classes of antidepressants?
Selective Serotonin Re-uptake Inhibitors (SSRI) Tricyclics Serotonin and Noradrenaline Re-Uptake Inhibitors (SNRI) Noradrenaline and Serotonin Specific Antidepressant (mirtazapine) Monoamine oxidase inhibitors
31
What is the first line class of antidepressant for depression?
SSRIs
32
What are examples of SSRIs?
Fluoxetine Sertraline Paroxetine Citalopram
33
What is the mechanism of SSRIs?
Block serotonin re-uptake from the synapse | Reduce inhibitory controls of serotonin release
34
What other conditions are SSRIs used for?
GAD Panic disorder Phobia OCD
35
What are the side effects of SSRIs?
GI upset (abdo pain, constipation, nausea) - usually settles in a couple weeks Increased risk of GI bleeds Increased anxiety, insomnia, agitation, sexual dysfunction Increased suicidality in first few weeks in younger patients Hyponatremia and falls in older patients Withdrawal
36
What are the withdrawal symptoms of SSRIs?
``` Flu-like symptoms Insomnia Nausea Imbalance Sensory disturbance Hyperarousal (FINISH) ```
37
What are examples of tricyclics?
``` Amitriptyline Nortriptyline Imipramine Lofepramine Clomipramine ```
38
What is the mechanism of tricyclics?
Block the re-uptake of noradrenaline and serotonin from the synapse by blocking their transporters
39
When are tricyclics used in depression?
Second line after SSRIs | Effective at reducing anxiety
40
When should tricyclics be avoided?
For patient working as driver or operating machinery - strong sedative Recent MI or history of arrhythmia
41
What are the side effects of tricyclics?
Sedation Weight gain Cardiac - long QT (arrhythmia), postural hypotension Anticholinergic - dry mouth, constipation, blurred vision, urinary retention sexual dysfunction
42
What are examples of SNRIs?
Venlafaxine | Duloxetine
43
What is the mechanism of SNRIs?
Selectively block the re-uptake of noradrenaline and serotonin from the synapse by blocking their transporters Weak antagonists of dopamine re-uptake
44
When are SNRIs used?
Second line to SSRI | If others not tolerated
45
What are the side effects fo SNRIs?
GI upset | Cardiac - HTN, palpitations, dizziness
46
What is the mechanism of mirtazapine?
Antagonizes presynaptic noradrenaline, serotonin and histamine receptors
47
When is mirtazapine used?
Second line For those where weight loss or sleep are issues Used in isolation or combination with SSRI
48
What are the side effects of mirtazapine?
Sedation Weight gain Can cause nausea or sexual difficulties but less likely to
49
What are examples of monoamine oxidase inhibitors?
Moclobemide | Phenelzine
50
What is the mechanism of monoamine oxidase inhibitors?
Block monoamine oxidase which presents the breakdown of serotonin and noradrenaline amongst other neurotransmitters
51
When are monoamine oxidase inhibitors used?
Good in atypical depression
52
What are the downsides off monoamine oxidase inhibitors?
Interact with tricyclics and SSRIs so need to be off them for several weeks before starting (risk of hypertensive crisis) Penelzine requires dietary restriction - avoid cheese, red wine, soy
53
What are the side effects of monoamine oxidase inhibitors?
Dizziness Postural hypotension Anticholinergic effects
54
How long do antidepressants take to work?
4-6 weeks
55
What is the general algorithm for order of antidepressants to try?
1. SSRI 2. Increase dose then try different SSRI 3. Switch to SNRI (or tricyclic) 4. Mirtazapine 5. Augment with antipsychotics, lithium
56
What antidepressant should be prescribed in the elderly?
Not SSRI due to hyponatremia/falls risk
57
What antidepressant should be prescribed in teenagers?
SSRI or mirtazapine
58
What antidepressant should be prescribed if sleep or weight loss is a major issue?
Mirtazapine