Depression

Question 1

What is the limbic system responsible for?

Answer 1

Emotions

Question 2

What are the 3 monoamines?

Answer 2

1. ) NE
2. ) Serotonin (5HT)
3. ) Dopamine

Question 3

2 ways that neuron terminates monoamine signal?

Answer 3

1. ) Monoamine oxidase- breaks them down

2. ) Monamine reuptake

Question 4

How did the first antidepressant work?

Answer 4

By blocking monamine breakdown and reuptake

Question 5

How do AD ACTUALLY work?

Answer 5

They overstimulate the nerves with monamines which then cause

1. ) Downregulation/ decrease in nerve number
2. ) Overstim/ anxiety

Question 6

Does downregulation help depression?

Answer 6

Yes

Question 7

How does stress effect the size of the hippocampus?

Answer 7

Increased stress = increased cortisol= decreased size of hippocampus

Question 8

how does Serotonin effect the hippocampus?

Answer 8

It increases the production of new cells to replaces the ones destroyed by cortisol

Question 9

SSRI side effects

Answer 9

1. ) Decreased sex drive
2. ) Worsen of suicidal thoughts
3. ) More side effects if stopped abruptly

Question 10

When are TCA (Tryplines) used?

Answer 10

Only if newer drugs don’t work

Question 11

How do Monamine Oxidase Inhbitors work? MAOI

Answer 11

Blocks the enzyme that metabolize monoamines so that they stay in the synapse longer

Question 12

Name 2 MAOI

Answer 12

1. ) Tranycypromine

2. ) Phenelzine

Question 13

What foods should be avoided with MAOI?

Answer 13

Cheese, fruits, wines, pickles

Foods containing Tyramine

Question 14

What is Emsam (Seligine)?

Answer 14

MAOI slow release patch.

Do not need diet restriction with this

Question 15

What drug acts as an SSRI at a low dose?

Answer 15

Effexor

Question 16

What does effexor increase?

Answer 16

1. ) Sero
2. ) NE

Good for severe depression

Question 17

What does Cymbalta(Duloxetine) Increase?

Answer 17

1. ) Sero

2. ) NE

Question 18

What does Wellbutrin (Bupropion) Increase?

Answer 18

1. ) dop
2. ) NE

low incidence of mania

Question 19

Which benzodiazepine reduces anxiety?

Answer 19

Clonazepam