Depression Flashcards
Selective Serotonin Reuptake Inhibitors (SSRIs)
Citalopram
Escitalopram
Fluvoxamine
Fluoxetine
Paroxetine
Sertraline
SSRI ADEs
initial anxiety
insomnia
headache
discontinuation syndrome
serotonin syndrome
hyponatremia
SIADH
Selective Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs)
Desvenlafaxine
Venlafaxine
Duloxetine
Levomilnacipran
SNRI ADEs
abnormal bleeding
increased risk of activation of mania
elevated BP
hyponatremia
serotonin syndrome
discontinuation syndrome
Serotonin Modulators
Nefazodone
Trazodone
Vilazodone
Vortioxetine (Trintellix)
Tricyclic Antidepressants
Amitriptyline
Amoxapine
Clomipramine
Desipramine
Doxepin
Imipramine
Nortriptyline
Maprotiline
Tricyclic Antidepressants ADEs
anticholinergic
CV
- ventricular tachycardia
-heart block
cognitive impairment
weight gain
sexual dysfunction
Monoamine Oxidase inhibitors (MAO-Is)
Phenelzine
Selegiline
Tranylcypromine
MAOI ADEs
postural hypotension
diarrhea
anticholinergic drying
sexual dysfunction
MAOI dietary restriction
Tyramine-
aged, smoked, and pickled products, also yeast extracts
First line agents
SSRI
SNRI
Bupropion
Mirtazapine
Vortioxetine
Neurologic Malignant Syndrome
Dopamine antagonists
onset variable 1-3 days
lead pipe rigidity
hyporeflexia
normal pupils
normal or decreased bowel sounds
Serotonin Syndrome
serotonin agents
onset variable < 12 hrs
hyperreflexia
dilated pupils
hyperactive bowel sounds
NMS common culprits
Haloperidol
Fluphenazine
Chlorpromazine
Trifluoperazine
Prochlorperazine
Special Population: Elderly
1st line: SSRI
2nd line: bupropion or venlafaxine
Mirtazapine benefits for anxiety, sleep, and appetite stimulation
AVOID TCAs
