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Flashcards in Depression Deck (16):
1

lifetime prevalence of depression

16% (#1 new dx in primary care)

2

big RF's for suicide?
biggest RF?

M + >65
past attempt

3

RF's for depression

Family hx
Personal hx
Female
Stressful events
Lack of support
Loss of parents early on
Child abuse
Substance use
Anxiety
Medical conditions

4

Classic stroke assoc w depression?

Left frontal lobe

5

lifetime risk for depression (M v F)

10% men
20% women

6

stressful life event can increase risk of depression by?

9x

7

stressful life event vs depressive episodes

link weakens as depression develops into a chronic illness i.e. you don't need an event to cause a new depressive episode

8

DSM criteria for MDD
SIGECAPS

Sleep (insomnia/hypersomnia)
Interest (/pleasure)
Guilt (worthless)
Energy (mood)
Concentration (indecisive)
Appetite (weight)
Psychomotor (agitatn/retardatn)
Suicidal

9

persistent depressive disorder

dysthmic disorder

10

part of anterior cingulate that's below the genu

subgenual PFC

11

part of cortex deep w/in brain, connects superior parts (frontal/parietal) with temporal, important for representation of bodily states

insula

12

what part of brain regulates amygdala activity?

VMPFC
more activity in VMPFC, less activity in amygdala
this control is loosened in depression, and actually a POSITIVE relationship is seen

13

fxnl/structural brain adaptations to the environment

plasticity
experience-dependent

14

cells that fire together wire together (who's law?)

learning/adaptive behavior

activity-dependent neuroplasticity (Hebb's Law)

experience-dependent NP

15

plasticity enhanced by?

psychotherapy
antidepressanys
ECT/DBS
Exercise
Phototherapy
Omega-3's

16

CBT (3 steps)

1. Notice auto thoughts/habits
2. Self-validation
3. Apply new skill (coaching, emotion regulation)

This very practice changes neural networks (e.g. PFC-amygdala)