derm crossword

Question 1

tetracycline used to treat acne, noteworthy for its ability to cause dark pigmentation in skin and sclera

Answer 1

minocycline

Question 2

cyclosporine and tacrolimus are among these agents that revolutionized transplantation therapy because they don’t cause bone marrow suppression. among other used includes topical or systemic administration for —?

Answer 2

calcineurin inhibitors

psoriasis and topical administration for anogenital pruritis

Question 3

route of administration where pharmacokinetic factors influencing absorption and distribution of drug include region, concentration, and vehicle

Answer 3

cutaneous

Question 4

organophosphate anticholinesterase insecticides, kills ectoparasites

Answer 4

malathion

Question 5

prescription synthetic topical antimycotic agent with broad spectrum activity

Answer 5

ciclopirox

Question 6

~50% water based, and 50% oil based with an emulsifier, base that is useful for covering large and/or wet areas with a drug but preservatives, etc, can cause allergic reactions

Answer 6

creams

Question 7

component of plant defenses against bacteria active against P. acne

Answer 7

azaleic acid

Question 8

late choice for treating ectoparasites, works by disrupting GABAergic transmission

Answer 8

lindane

Question 9

urea, alpha-hydroxyl acids and allantoin are among the agents found in moisturizers to soften this and give a smoother feeling (2 words)

Answer 9

horny substance

Question 10

refers to localized pruritis caused by compression/damage to nerves; anticonvulsants gabapentin or pregabalin may provide relief

Answer 10

neuropathic

Question 11

topical treatment o lesions due to herpes simplex

Answer 11

acyclovir

Question 12

example of body region where topically applied agents would be rapidly absorbed

Answer 12

axlla

Question 13

low pressure implementation of this with normal saline is an important component of healing, especially for larger wounds

Answer 13

irrigation

Question 14

delayed hypersensitivity reaction that can be caused by substances such as latex and drugs such as neomycin and bacitracin; sometimes induced as treatment of skin disorder (i.e. psoriasis and alopecia)

Answer 14

contact dermatitis

Question 15

K+ sparing diuretic with partial agonist propoerties at androgen receptors that can make it useful for treating menstrual cycle-linked acne of male pattern baldness in adult women

Answer 15

spironolactone

Question 16

most important component of infection control

Answer 16

hand hygeine

Question 17

platelet-derived growth factor that stimulates diabetic ulcer repair, but must use cautiously as too much increases risk of malignancy

Answer 17

becaplermin

Question 18

orally administrated insecticide to treat ectoparasites, binds glutamate-activated Cl- channels to hyperpolarize the nerve and muscle cells

Answer 18

ivermectine

Question 19

treated surgically when possible with 1-2 cm margins and conventional chemotherapy based on dacarbazine; vermurafenib is also useful in the ~60% that have the BRAF V600D gene mutation

Answer 19

melanoma

Question 20

common cause of diarrhea due to antibiotic-associated colitis, well known example where handwashing with soap and water is superior to acohol-based gels

Answer 20

C Difficile

Question 21

macrlide antibiotic, among uses is for topical or systemic treatment o acne; among the well-known cytochrome P450 inhibitors

Answer 21

erythromycin

Question 22

imidazole antifungal drug applied topically or range of fungal infections, also noteworthy as a classic inhibitor of cytochrome P450

Answer 22

ketoconazole

Question 23

local vasoconstriction due to blood volume deficit, unrelieved pain, hypothermia, etc, can impair wound healing due to inadequate amount of this inthe tissue

Answer 23

oxygenation

Question 24

can be effective treatment for acne in women

Answer 24

combination oral contraceptive

Question 25

to heal best, wounds should be kept clean and

Answer 25

moist

Question 26

potent vasodilator due to hyperpolarization via activation of K+ channels, applied topically to grow hair

Answer 26

minoxidil

Question 27

when used to treat thrush, it is held in the mouth before swallowing (has negligible GI absorption)

Answer 27

nystatin

Question 28

retinoid administered orally for treatment of severe acne, powerful teratogen that mandates participation by prescribers and used in the iPledge program

Answer 28

isotretinoin

Question 29

most common handwashing error in clinical setting

Answer 29

inadequate time

Question 30

applied to inanimate objects to kill microbes

Answer 30

disinfectant

Question 31

blocking this radtion was ~ only goal of early sunscreens; also used to treat psoriasis

Answer 31

UVB

Question 32

good wound coverings during the debridement phase of healing

Answer 32

hydrogels

Question 33

anti-inflammatory agent known since anciet times, keratolytic effects due to its ability to dissolve intercellular cement make it useful for treatment of acne, dandruff and calluses

Answer 33

salicylic acid (ASA)

Question 34

important for optimal wound healing

Answer 34

nutrition

Question 35

useful topically for fungal infections such as jock itch and athlete's foot and systemically for fungal nail infections

Answer 35

terbnafine

Question 36

agents such as iodine, chlorhexidine and hydrogen peroxide and potentially do this to wound healing

Answer 36

impede

Question 37

class of antifungal drugs with a wide range of activity, blocks ergosterol synthesis

Answer 37

imidazoles

Question 38

biologic DMARD directed against IL-17a, used to treat psoriasis and psoriatic arthritis and, for some works much better than anti-TNF therapies

Answer 38

secukinumab

Question 39

class of adrenergic agonists administered topically to treat rosacea or red eyes; bimonidine oxymetazoline and tetrahydrozyline are example

Answer 39

alpha

Question 40

form on surfaces, very hard to kill because 1) resident microbes of different species help each other survive and 2) some also form phenotype that replicates slowly

Answer 40

biofilms

Question 41

effective treatment for acne primarily because o its simple/easy to follow strategy

Answer 41

proactiv

Question 42

monoclonal antibody against IL-12 and IL-23, a biologic agent used to treat psoriasis

Answer 42

ustekinumab

Question 43

prototypical non-steroid androgen antagonist, uses include treatment of prostate cancer and male pattern baldness in women

Answer 43

flutamide

Question 44

very important component of skin care for health care providers

Answer 44

moist urizers

Question 45

antibiotic that works similar to macrolides, kills anaerobes, useful for range of infections including topical treatment of acne and for osteomyelitis; associated with increased risk of C. Dificile

Answer 45

clindamycin

Question 46

topical immune response modifier used to treat actinic keratoses and basal or squamous cell carcinoma; also used to treat genital warts

Answer 46

imiquimod

Question 47

characterizes the topical glucocorticoids that should be applied to face, genitals and skin folds

Answer 47

low potency

Question 48

refers to substance in moisturizers that form an oily layer to trap water in the skin/treat dry skin; petrolatum, lanolin, and mineral oil are among common examples

Answer 48

emolients

Question 49

control that is now considered a priority for optimal wound closure

Answer 49

glycemic

Question 50

example of systemic therapy to treat tinea versicolor

Answer 50

flucanzole

Question 51

orally administered phosphodiesterase type 4 inhibitor used to treat moderate to severe plaque psoriases

Answer 51

apremilast

Question 52

broad-spectrum antimicrobial agent widely used in homes and hospitals due to efficacy on skin and oral mucosa with low irritablity

Answer 52

chlorhexidine

Question 53

the formation of one of these after drug application to the skin may prolong its half-life enough to permit 1/day dosing

Answer 53

reservoir

Question 54

drug class useful for systemic treatment of acne, photo-sensitivity, GI distress and contraindication in pregnancy and young children due to gray discoloration of permanent teeth are noteworthy adverse effects

Answer 54

tetracycline

Question 55

chronic kidney disease, biliary obstruction, diabetes, hypo-and hyperthyroidism, hodgkin's disease, polycythemia vera and pregnancy are among the common systemic causes of this

Answer 55

pruritis

Question 56

applied to skin to kill microbes

Answer 56

antiseptic

Question 57

peptide antibiotic with efficacy against gram- bacteria including pseudomonas, has a detergent-like effect that manages the bacterial cell membrane

Answer 57

polymixib

Question 58

lower, closer to that of skin is why synthetic detergents minimize skin irritation during home skin care

Answer 58

pH

Question 59

topical administration formulations have 7 potency classes so that it is possible to taper down to the lowest dose needed to control inflammation

Answer 59

glucocorticoids

Question 60

refers to autoantibody mediated hair loss that is treated with corticosteroids and/or an agent such as DPCP to induce a contact dermatitis with typical hair growth restoration in the healed skin

Answer 60

alopecia areata

Question 61

antifungal agent with topical effects limited to candida infections, may temporarily stain the skin yellow

Answer 61

amphotericin B

Question 62

important component of wound healing, it conserves the local resources by limiting the need to synthesize proteases

Answer 62

debridement

Question 63

synthetic insecticides similar to that of chrysanthemums, ectoparasite therapy that blocks membrane repolarizing

Answer 63

permethrin

Question 64

topical antimicrobial agent commonly used to treat acne; local skin irritant and may blech hair or clothing

Answer 64

benzoylperoxide

Question 65

macrolide among the systemic therapies used to treat acne; not a cytochrome P450 inhibitor, unusual pharmacokinetics in that it is taken up in phagocytes and released by them at sites of infection

Answer 65

azithromycin

Question 66

refers to agents such as glycerin, lecithin and propylene glycol found in moisturizers to draw water into the outer layer of skin

Answer 66

humectants

Question 67

peptide antibiotic with activity against gram + organisms and some anaerobes; only applied topically to limit systemic toxicity often causes contact dermatitis

Answer 67

bacitracin

Question 68

somewhat surprisingly, making it a good distractor on exams, this does no promote wound healing

Answer 68

EGF

Question 69

effective topical therapy for actinic keratoses, causes fast-proliferating dysplastic cells to die a thymidine-less death; necrosis/erosion gives way to re-epithelization over several weeks

Answer 69

5-fluorouracil

Question 70

treatment for actinic keratoses derived from euphorbia peplus sap, causes chemoablation with neutrophil-mediated antibody dependent cellular cytotoxicity eliminating remaining tumor cells

Answer 70

ingenolmebutate

Question 71

aminoglycoside antibiotic of neosporin with activity against gram - bacteria

Answer 71

neomycin

Question 72

compromised of ~20% water and 80% oils, best for dry skin, stay on the surface of skin and are not well absorbed, permit more complete drug absorption and less llikely to cause allergic reaction skin no preservatives

Answer 72

ointments

Question 73

among OTC drug used to treat jock itch and athletes' foot, like terbinafine, inactive against yeasts

Answer 73

tolnaftate

Question 74

very old remedy for psoriasis; works but color and smells create a challenge

Answer 74

TAR

Question 75

among the wound coverings perferreed during the granulation and epithelization phases of wound healing

Answer 75

low adherance

Question 76

blocks the conversion of testosterone to more potent androgen dihydyrotestosterone, among its uses is to treat male pattern baldness in men and second-line agent for this in women

Answer 76

finasteride

Question 77

drug class that may or may not stop the itch, but the associated drowsiness may help

Answer 77

anti-histamine

Question 78

titanium dioxide is an example that could be applied, for example to your nose when on the beach

Answer 78

sunshade

Question 79

topical retinoid administered or the treatment of acne, aters gene expression to normalize keratinization, decrease keratinocyte cohesiveness and reduce microcomedone formation

Answer 79

tretinoin

Question 80

among the imidazole drugs commonly used to treat vulvovaginal candidiasis

Answer 80

miconazole

Question 81

radiation that may not cause erythema and sunburn but nevertheless still does contribute to skin aging and photocarcinogenesis; under strict supervision, used in combination with photosensitizer psoralens to treat psoriases

Answer 81

UVA

Question 82

inhibitors of this signaling pathway can be used to treat advanced basal cell carcinoma but usually treated surgically and/or topically

Answer 82

SHH