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Integumentary > Derm Drugs (Pt II) > Flashcards

Derm Drugs (Pt II) Flashcards

1
Q

Topical glucocorticoids have what type of effect and can result in what if used chronically?

A

anti-inflammatory and immunosuppressive effects; can result in tachyphylaxis

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2
Q

MOA of topical glucocorticoids?

A

alter gene expression by binding to glucocorticoid response elements on DNA

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3
Q

which topical glucocorticoid is used for corticosteroid-responsive dermatoses?

A

hydrocortisone

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4
Q

Which topical glucocorticoid is used for corticosteroid-responsive dermatoses of scalp, and plaque psoriasis?

A

Betamethasone

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5
Q

Which topical glucocorticoid is used for corticosteroid-responsive dermatoses of scalp, and plaque psoriasis >18 y/o?

A

Halobetasol

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6
Q

Which topical glucocorticoid is used for corticosteroid-responsive dermatoses and psoriasis but has an adverse effect of growth retardation in children?

A

Clobetasol

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7
Q

Which topical glucocorticoid is used for corticosteroid-responsive dermatoses of scalp and moderate-severe atopic dermatitis in pediatric pts?

A

Fluocinolone

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8
Q

Combo of a topical retinoid w/ what is more efficacious than mono therapy?

A

antimicrobial

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9
Q

Which topical retinoid binds to specific retinoic nuclear receptors, is comedolytic, bactericidal, and normalizes desquamation?

A

Adapalene

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10
Q

Which topical retinoid cannot be used in pregnancy, has anti-inflammatory properties and is more effective when combined with an antimicrobial?

A

Tretinoin

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11
Q

What is a prodrug that is hydrolyzed by an esterase and binds to retinoic receptors to tx acne vulgaris, psoriasis, etc.?

A

Tazarotene

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12
Q

Which topical retinoid is a pregnancy category X?

A

Tazarotene

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13
Q

Which systemic retinoid decreases sebum and is used to tx SCC but is a teratogen?

A

Isotretinoin

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14
Q

Women of childbearing age have to be using 2 forms of contraception and monthly pregnancy test in order to use which drug?

A

Isotretinoin

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15
Q

what affects <10% of body surface area, is caused by drugs and occasionally Mycoplasma?

A

SJS

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16
Q

What affects >30% BSA, potentially fatal, and is due to drugs?

A

TEN

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17
Q

What type of drugs are 1st line for pruritis should be cautioned in the elderly population?

A

Antihistamines

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18
Q

(T/F) Sedating H1 receptor and H2 receptor agonist have at most a limited effect in tx of chronic itch

A

FALSE- Nonsedating; sedating may be best at night and is better

19
Q

which antihistamine is used for chronic urticaria, drug-related itch and are CI in neonates, premature infants, and nursing moms?

A

Diphenhydramine

20
Q

which drug blocks H1 and H2 receptors to tx moderate pruritis but cannot be given w/ antidepressants bc it can prolong the QT interval?

A

Doxepin

21
Q

Black box warning for doxepin?

A

increases suicidality risk in children- young adults w/ major psych disorders!

22
Q

which oral antihistamine is used to tx histamine mediated pruritis and doesnt mix well w/ sertraline?

A

Hydroxyzine

23
Q

Which hypo pigmentation agent inhibits tyrosinase and reduces hyperpigmentation (temporary lightening) and can have possible carcinogenicity?

A

Hydroquinone

24
Q

Which hypopigmentation agent causes irreversible depigmentation and should be restricted to pts w/ widespread vitiligo?

A

Monobenzone

25
Q

Which hypopigmentation agent is a substrate for the enzyme tyrosinase & is competitive inhibitor of the formation of melanin precursors and used for solar lentigines?

A

Mequinol

26
Q

Mequinol combined w/ what drug may cause fetal harm?

A

Tretinoin

27
Q

trichogenic agent used to stimulate hair growth secondary to vasodilation that reverses progressive miniaturization of terminal scalp hairs?

A

Minoxidil (topical)

28
Q

Which trichogenic agent is 5 alpha reductase inhibitor promotes hair growth and should not be used in pregnant women?

A

Finasteride (oral)

29
Q

Which trichogenic agent is a synthetic analog of prostaglandin and is used for eyelashes?

A

Bimatoprost (ophthalmic solution)

30
Q

what is a chronic autoimmune inflammatory disease has a significant genetic and environmental association and IL-12,IL-17, and IL-23?

A

Psoriasis

31
Q

Which oral psoriasis tx activates retinoid acid receptors to tx severe psoriasis and should NOT be used in pregnancy?

A

Acitretin

32
Q

Which oral psoriasis tx is a selective inhibitor of PDE4 and inhibits spontaneous production of TNF alpha?

A

Apremilast

33
Q

Which psoriasis tx binds to vitamin D receptors and inhibits keratinocyte proliferation while enhancing differentiation?

A

Calcipotriene

34
Q

Which psoriasis tx is better tolerated and is used to tx plaque psoriasis?

A

Calcitrol

35
Q

Which biologic agent is a decoy receptor?

A

Etanercept

36
Q

Which biologic agent is a partially humanized mouse antibody against TNF alpha?

A

Infliximab

37
Q

Which biological agent is a fully human IgG1 antibody?

A

Adalimumab

38
Q

Which biological agent binds selectively and neutralizes human TNF alpha activity?

A

Certolizumab

39
Q

Before starting biologics, always check what..?

A

check PPD to r/o TB

40
Q

Which biologic agent binds w/ high affinity and specificity to the p40 protein subunit used by both IL-12 and IL-23 ?

A

Ustekinumab

41
Q

Which biological agents bind selectively to the p19 subunit of IL-23?

A

Guselkumab, Tildrazkizumab, Risankizumab

42
Q

which biological agents are used to bind selectively w/ IL-17A?

A

Secukinumab and Ixekizumab

43
Q

Which biological agent binds selectively w/ the IL-17A receptor and has a black box warning of suicidal ideation and behavior?

A

Brodalumab

Integumentary (4 decks)

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