Derma lectures Flashcards
(107 cards)
1
Q
Tuber=
A
Cellular infiltration in the reticular dermis and SC
2
Q
Gumma is a type of
A
Tuber
3
Q
Urticaria=
A
Edema of the dermis
4
Q
Etiology of lower limb ulcers
A
Venous insuff. Arterial insuff.- PAD Neuropathy Microcirculation abnormalities Vasculopathy Vasculitis Pyoderma gangrenosun Tumor Injury Infection
5
Q
Inflammation of the layer of fat under the skin=
A
Panniculitis
6
Q
Leg looks like this- Livid brown color Atrophy Scarring Loss of hair
What is it called?
A
Lipodermatosclerosis
7
Q
Venous ulcer location and properties
A
Mainly above inner/outer ankle
Moderate pain
Not deep
Irregular shape
8
Q
Artrial ulcer location and properties
A
Sharply demarcated
Ring shape
Tose are not affected
Very painfull
9
Q
Pyoderma gangrenosum- describe the ulcer
A
Painful Devrlops rapidly Purple Pustules Ulcers Mainlly on shins
10
Q
Treatment for acne vulgaris
A
Benzoyl peroxide Retinoids Tretinoin gel Azelaic acid Erythromycin Oral isotretinoin Anti adronergic drugs- Spironolactone
11
Q
Rosacea=
A
Chronic inflammatory skin disease in the central face with flushing erythema telangiectasia, papules and pustules
12
Q
Rosacea treatment
A
Metronidazole
Low dose Doxyxycline
Azelaic acid
Isotretinoin
13
Q
Lichen Planus etiology
A
Unknown
Possible autoimune (Ab against desmoglein 3/ collagen VII
Associated with Hep. C
Stress
14
Q
Lichen Planus- how does it look like?
A
Pruritic Purple Papule Polygonal Wickham's striae Nail distrophy
15
Q
NGU
לפרטנרים מלפני כמה זמן צריך לעדכן
A
2 months
16
Q
Syphilis
לפרטנרים מלפני כמה זמן צריך לעדכן
A
Primary- 3 months
Secondary- 6 months
Early latent- 12 months
17
Q
Vaginal pH
A
3.8-4.7
18
Q
Syphilis most common non specific test
A
RPR
19
Q
Syphilis most common specific test
A
TPPA
20
Q
We give in case of Syphilis what I.M?
How much in primary?
A
Benzatene Penicillin
2.4 million I.U
21
Q
Atypical course of Lymphogranuloma venarum
A
Intraanal entry -> Purulent proctitis (looks like IBD) -> Strictures and pistula
22
Q
Lymphogranuloma venarum treatment
A
Doxycycline 2X100 mg for 21 days
23
Q
HPV incubation period
A
6-12 months
24
Q
Which virus doesnt have a specific therapy?
A
HPV
25
Lyme disease general treatment
Doxyxycline 100 mg X 2 per day for 10-21 days
Cefuroxime 500 mg X 2 per day for 10-21 days
26
Folliculitis Furuncle Carbucle treatment
Fuzidic acid
Penicillin
Cephalosporin
27
Impetigo local treatment
Mupirocin oinment
Fusidin acid oinment
Betadine
28
Erysiples treatment
Systemic aminopenicillin
Cephalosporines
Clindamycin
Ciprofloxacin
29
Herpes zoster treatment
Systemic acyclovir 5X800 mg
| Painkillers
30
Scabies treatment
Benzoyl benzoat
Permethrin leave on for 12 h
Ivermectin
31
Classifications of Cutan lupus erythematus
Acute
Sub acute
Chronic
32
What is always present in case of Cutan lupus erythematus
Photosensitivity
33
Which Cutan lupus erythematus is always a part of SLE?
Acute CLE
34
Genetic factors affecting CLE
MHC complex and comlement cascade
35
Enviormental factors affecting CLE
```
UV
Smoking
Cold
Female hormones
Drugs
Infections
Stress
```
36
Which Ab are present in CLE?
```
ANA
SSA
SSB
Anti-dsDNA
C1q AB
```
37
Acute CLE symp.
Butterfly erythema
| Photosensitivw lupus dermatitis
38
Subacute CLE symp.
Annular
| Papulosquamous/psoriasiform
39
Annular form in SCLE describe it
Erythematous
Central atrophy
Scaly plaques
40
SCLE treatment
Avoid sun
Local cortico.
Chloroquine/Hydroxycloroquine
Systemic cortico.
41
Chronic CLE can be divided into
Localized discoid
Generalised discoid
Hypertrophic
Tumidos
42
What is the most fequent form of CCLE?
Discoid LE
43
Discoid LE skin symp.
```
Erythematous
Telangiectasia
Plaques covered with hyperkeratosis
Scar formation
Scarring alopecia
```
44
Sprcial feature of Discoid LE
Scarring alopecia
45
LE therapy
```
UV protection
Vit. D
Quit smoking
Local cortico.
Antimalarial drugs
Azathioprin
Methotrexate
Biologic therapy
```
46
Biologic therapy for LE
Belimumab
47
What is the most frequent form of CLE?
Discoid
48
SCLE clinically can be two forms-
Annular
| Psoriasiform
49
How does SCLE regress?
Vitiligo like hypopigmented mucules
50
Localized scleroderma=
Morphea
51
Two phases of localized scleroderma
Initial inflammatory
| Late fibrotic
52
Localized scleroderma Limited types (3)
Plaque morphea
Guttate morphea
Suprficial morphea
53
Generalized morphea definition
4 or more plaques of more than 3 cm involving 2 ore more anatomical regions
54
Which scleroderma is common in kids?
Linear
55
Localized scleroderma treatment
| Limited skin involvement
Topical cortico.
Topical calcineurin
PUVA
56
Localized scleroderma treatment
| Severe skin involvement
MTX 12 months
Methylprednisone
Prednisolone
57
Localized scleroderma Limited types
| Which is most common
Plaque type
58
Localized scleroderma Limited types
| What is a sign of active inflammation?
Lilach ring
59
What can causes the mortality in case of Dermatomyositis?
Interstitial Lung Didease
60
Diagnostic criteria for Dermatomyositis
```
Proximal muscle weakness
Positive muscle biopsy
Increased skeletal muscle enzymes
EMG
Cutaneous symp.
```
61
Dermatomyositis Cutaneous symp.
```
Heliotrop rash
Livid erythema
Scalp involvement
Gottorn papules (MCP)
Gottorn sign (Elbows, knees)
V sign
Periungual sign
Poikiloderma
```
62
Another type of Dermatomyositis
Amyopathic Dermatomyositis
63
Is psoriasis itchy?
Not that much
64
Primary and secondary lesions found in Psoriasis
```
Plaque
Patch
Papules
Scaling
Fissures
Rhages
```
65
Psoriatic skin lesions induced by traume to the skin is also called
Koebner phenomenon
66
Psoriasis prelevance
1-2% of adults
67
Genetics assoiciated with Psoriasis
HLA-B27
68
Medications that can evoke Psoriasis?
B Blockers
Lithium
INF-a
69
Psoriasis- where is it usually found on the body?
```
Elbows
Knees
Scalp
Back
Nails
Folds
```
70
Nails symp. in Psoriasis
```
Beau pitting
Oildrop sign
Onycholysis
Keratosis
Dystrophy
```
71
Histology findings in Psoriasis
Papillomatosis
Acanthosis
Parakeratosis
72
What is Guttate Psoriasis
Many smll scaly papules
73
Guttate Psoriasis is often triggered by
Strep.
74
Special forms of Psoriasis
Erythrodermic
Pustulosa
Inverse
Palmoplantar
75
Scoring systems for Psoriasis
PASI (Psoriasis Area Severity Index)
| BSA (Body Surface Area)
76
For patient with 90% PASI (Psoriasis Area Severity Index) how will you treat?
```
Methotrexate= Folic acid antagonist
Adalimumab= Anti TNF-a
```
77
Treatment for Buulous Pemphigoid
Methotrexate
Azathioprin
Dapson
Doxyxycline
78
Define Dermatitis herpatiformis
Autoimmune bullous disease
79
Auto-Ag in Dermatitis herpatiformis
Tranglutaminase 3
80
Describe classic case of BCC
```
Sun exposed skin
Old age
Shiny
Pearly border
Telangiectasia
Ulceration
```
81
Types of BCC
Nodular
Superficial
Pigmented
82
Low risk BCC treatment
Surgical excision with 3-5 mm borders
83
High risk BCC treatment
MOHS surgery (Microscopically Oriented Histologic Surgery)
84
Non surgery BCC treatment
Radiation
Cryotherapy
Laser therapy
Sonidegib
85
How do we classify SCC
By differentiation
Well, moderate, poorly
86
In which case will we use radiation in SCC?
In situ form, does not invase the BM
87
SCC therapy most likely will be
MOHS
88
Which skin cancer do not form on mucos mmb.?
BCC
89
Which cancer is in connection with chronic sun exposure?
SCC
90
Melanoma classification
Superficial spreading
Nodular
Lentigo maligna
Acral lentigoid
91
Therapy for primary melanoma
Surgical removal with 5-20 mm border according to Breslow scale
92
Breslow I means
Intraepidermal
93
Breslow V means
Enters fat
94
Melanoma immunotherapy
Nivolumab
| Pemprolizumab
95
New therapy for Melanoma?
Ipilimumab (Target cytotoxic T cells)
| Vemurafenib
96
Psoriasiform hyperplasia=
Elongation of rete ridges and elongation of dermal papillae
97
Which WBC are found in Billous pemphigoid and where can we find them?
Eosinophils
| In the papillary dermis and the blister fluid
98
Dermatitis herpatiformis
| What will we see on histology and on IF?
Fibrin and neutrophils at the tip of dermal papillae
Small microabscess
IgA type Ab at the tips of dermal papillae
99
Special histological feature of BCC
Palisade
100
SCC may arrise from (2 lesions)
Keratoacanthoma
| Actinic keratosis
101
Common mole is also called
Melanocytic nevi
102
Where can we find junctional nevus?
Epidermis
103
Where can we find compound nevus?
Epidermis and dermis
104
Nevus that is only present in the dermis?
Intradermal
105
Dermis can be divided into
Papillary dermis
Papillary reticular
Reticular dermis
106
Kaposi sarcoma
```
Purple
Singular/wide spread
Flat/raised
HHV8
Immunosuppression
AIDS
Skin
Mucosal
Internal organs
```
107
Kaposi sarcoma histology
Plump spindled shape stromal cells
