Dermatology Flashcards
(153 cards)
WHAT IS ECZEMA?
Papules and vesicles on an erythematous base.
ITCHY!!!
Reaction pattern to stimuli
What are the two type of eczema?
What is the exogenous one precipitated by?
- Endogenous (atopic)
- Exogenous (contact dermatitis)
Contact dermatitis is a type of eczema precipitated by an exogenous agent e.g. chemicals, sweat, abrasives
What is filaggrin?
Skin barrier protein
If damaged increases the risk of eczema
Genetic predisopsition
What is the treatment of eczema?
- Emollients
-
Topical steroids
- Mild - hydrocortisone
- Moderate - Betamethasone
- Potent - Fluticasone
- Very potent - Clobetasol
- UV radiation
-
Immunosuppressants:
- e.g. ciclosporin, antihistamines and azathioprine
WHAT IS ACNE?
Inflammatory disease of the pilosebaceous follicles
What is the pathology of acne?
- Increased sebum production (hormonal in adolescents)
- Abnormal follicular keratinization
- Pilosebaceous duct obstruction
- Bacterial colonisation with Propionibacterium acne
- Inflammation
P. acnes
What is the presentation of acne?
- Blackheads and whiteheads (open and closed comedomes)
- Inflammatory lesions
- Papules
- Nodules
- Cysts
What is the management of acne?
-
Mild
- Topical therapies e.g. benzylperoxide and topical antibiotics and topical retinoids
- Topical adapalene with benzyl peroxide
-
Moderate
- Oral therapies
- e.g. oral antibiotics - erythromycin, doxycycline
- anti-androgens in females (COCP or cyproteroneacetate)
-
Severe
- Oral retinoids
WHAT IS PSORIASIS?
Chronic, inflammatory skin disease due to hyper-proliferation of Keratinocytes + inflammatory cell infiltration
Well demarcated erythematous plaques topped with silvery scales
NOT ITCHY
Where can psoriasis be seen?
Extensor surfaces
Associated nail changes: pitting, onycholysis

What are the precipitating (flare up) factors for psoriasis?
- Trauma
-
Drugs
- Lithium
- Beta blockers
- Stress
- Smoking
- Alcohol
What is the treatment for psoriasis?
Mild
- Regular emollients may help to reduce scale loss and reduce pruritus
-
First-line: NICE recommend:
- Potent corticosteroid applied once daily plus vitamin D analogue applied once daily, for up to 4 weeks as initial treatment -
Second-line: if no improvement after 8 weeks then offer:
- A vitamin D analogue twice daily -
Third-line: if no improvement after 8-12 weeks then offer either:
- A potent corticosteroid applied twice daily for up to 4 weeks, or a coal tar preparation applied once or twice daily
NEED TO WAIT 4 WEEKS IN BETWEEN EACH STEROID COURSE
Moderate
Phototherapy
Severe
Oral methotrexate
Retinoids
Ciclosporin
Infliximab
What is Koebner phenomenon?
The Koebner phenomenon describes skin lesions that appear at the site of injury. It is seen in:
- psoriasis
- vitiligo
- warts
- lichen planus
- lichen sclerosus
- molluscum contagiosum
WHAT ARE THE FEATURES OF A BCC?
What is it a tumour of?
Does it metastasise?
- Slow growing
- Locally invasive
- Tumour of the epidermal keratinocytes
- Rarely metastasises but locally destructive

What are the risk factors for a BCC?
- UV exposure
- Skin type 1 (burns rather than tans)
- Aging
What is the presentation of a BCC?
- many types of BCC are described. The most common type is nodular BCC, which is described here
- sun-exposed sites, especially the head and neck account for the majority of lesions
- initially a pearly, flesh-coloured papule with telangiectasia
- may later ulcerate leaving a central ‘crater’
What is the treatment of a BCC?
Surgically excise
Radiotherapy if surgery is not appropriate
What are the complications of a BCC?
Local tissue destruction
WHAT IS A SCC?
Locally invasive malignant tumour of keratinocytes

What are the risk factors for a SCC?
- Excessive exposure to sunlight / psoralen UVA therapy
- Actinic keratoses and Bowen’s disease
- Immunosuppression e.g. following renal transplant, HIV
- Smoking
- Long-standing leg ulcers (Marjolin’s ulcer)
- Genetic conditions e.g. xeroderma pigmentosum, oculocutaneous albinism
What is the presentation of a SCC?
Scaly and crusty, ill-defined edges, may ulcerate

What is the management of a SCC?
- Surgical excision with 4mm margins if lesion <20mm in diameter.
- If tumour >20mm then margins should be 6mm.
- Mohs micrographic surgery may be used in high-risk patients and in cosmetically important sites.
WHAT IS A MELENOMA?
Invasive tumour of melanocytes
What are the risk factors for a melenoma
- UV exposure
- Skin type 1
- Atypical moles
- Multiple moles
- Family history


























