Dermatology CVT Flashcards
(44 cards)
What type of neoplasia has been associated with feline-acquired skin fragility?
Hepatic neoplasia
What is linear preputial erythema seen with?
Testicular neoplasia (sertoli cell tumor and seminoma)
What 2 neoplasia in a cat have been associated with symmetrical ventral alopecia in which the skin appears shiny?
Pancreatic adenocarcinoma (most common with hepatic mets) and bile duct carcinoma (2 reports)
In which disease had an exfoliative dermatiits in cats been described?
Thymoma
In what breed has a syndrome of nodular dermatofibrosis been described and what is it associated with?
GSD - autosomal dominant inheritance
Renal cystadenocarcinomas or cystadenomas
NOTE: Female dogs can also get uterine leiomyomas - they should be spayed
In dogs, what is paraneoplastic pemphigus linked to?
Antibodies that target desmoplakin, envoplakin, perplakin, desmoglein I and 3 = All proteins that are responsible for connections btwn keratinocytes
What is superficial necrolytic dermatitis associated with?
Glucagonoma (more commonly with a yet to be determined alteration in metabolism = depletion of AA)
Where is zinc found in highest concentration?
Nasal planum, tongue, foot pad (keratinized tissue)
What is Syndrome I and in which breeds is it common?
Zinc Responsive Dermatitis (skin has a flaky silver appearance)
Siberian huskies, Alaskan malamutes, other breeds
Not related to unbalanced diet
In which breed is there a Zn responsive dermatitis in puppies (thought to be rapidly growing)?
Pharaoh hound puppies - Syndrome II
In what breed is lethal acrodermatitis seen?
White Bull Terriers
CS within a few weeks of life, crusting on extremities and mucocutaneous junctions = Bronchopneumonia and sepsis
What odd PE findings can be found in lethal acrodermatitis?
White Bull Terriers
Arched hard palate, stunted growth, splayed digits
What is another name for heptocutaneous syndrome?
Superficial necrolytic dermatitis
What other conditions can superficial necrolytic dermatitis be seen with?
Hepatopathy (vaculor, phenobarb)
Glucagonoma of pancreas
GI disease (PLE)
Which breeds may be predisposed to hepatocutaneous syndrome?
Shetland sheepdogs
West Highland White Terriers
Cocker Spaniels
Scottish Terriers
What AUS finding is consistent with superficial necrolytic dermatitis?
Honeycomb pattern (Hypoechic regions surrounds by hyperechoic borders)
What is low in animals with superficial necrolytic dermatitis?
Hypoaminoacidemia - Less than 60% of normal
What are cutaneous xanthomas?
Occur when there is an underlying hereditary defect in lipid metbolism or acquired dyslipoproteinemia secondary to diabetes mellitus, or use of megesterol acetate
= Lipid-laden macrophags within the dermis - Pale yellow to white plaques, papules, nodules with erythematous border = Located on the head, particularly near pinnae
Which breeds are at an increased risk of developing SLE?
Collie, Shetland Sheepdog, GSD, Spitz, poodle
What percentage of dogs will develop skin disease with SLE?
Less than 20%
Most common CS of SLE = Fever, polyarthritis, PLN, anemia, thrombocytopenia
What is erythema multiforme?
Acute onset of erythematous plaques and macules
Need to look for trigger: Drugs, infection, neoplasia (majority of dogs we do not find the cause)
What is sterile nodular panniculitis?
Ulcerated or draining nodular lesions or nonculerative SQ nodules
Often febrile
What concurrent diseases have been identified with sterile nodular panniculitis in dogs?
Pancreatic disease (pancreatitis and pancreatic neoplasia) IM disease (polyarthritis, SLE, rheumatoid arthritis)
How is cyclosporine metabolized in the liver?
CYP450 3A12 - ketoconazole inhibits this!!
