Dermatology/Rheumatology

Question 1

Treatment of bowens disease

Answer 1

Topical 5 fluoracil

Question 2

Treatment of rosacea

Answer 2

Topical metronidazole (mild symptoms)
Brimonidine gel
Oxytetracycline orally if severe symptoms

Question 3

What is the most common cardiac manifestation of lupus?

Answer 3

Pericarditis

Question 4

What antibodies are associated with polymyositis?

Answer 4

Anti synthetase antibibodies

Anti Jo 1

Question 5

Causes of osteomalacia

Answer 5

Vitamin D deficiency 
Chronic kidney disease 
Anticonvulsant medications 
Inherited 
Liver cirrhosis

Question 6

Blood results in osteomalacia

Answer 6

Low vitamin D
Low calcium
Low phosphate
Raised alkaline phosphatase

Question 7

Treatment of osteomalacia

Answer 7

Vitamin D supplementation

Question 8

What is the inheritence pattern of hereditary haemorrhagic telangiesctasia?

Answer 8

Autosomal dominant

Question 9

What are the symptoms of pellagra (niacin deficiency)

Answer 9

Dermatitis, diarrhoea and dementia

Question 10

Treatment of pyoderma gangrenosum?

Answer 10

Oral steroids

Ciclosporin/Infliximab in some cases

Question 11

Blood results in pagets disease?

Answer 11

Raised ALP. Normal calcium and phosphate

Question 12

Treatment for pagets disease

Answer 12

Bisphosphonates

Question 13

What is the most common malignancy associated with acanthosis nigricans

Answer 13

Gastrointestinal cancer

Question 14

What is the gold standard diagnostic investigation for polymyositis?

Answer 14

Muscle biopsy

Question 15

First line treatment for chronic plague psoriasis

Answer 15

Topical potent corticosteroid and vitamin D analogue

Question 16

Antibodies for drug induced lupus?

Answer 16

Anti histone antibodies

Question 17

What are the most common causes of drug induced lupus

Answer 17

Procinamide

Hydralazine

Question 18

How does denosumab work?

Answer 18

Human monoclonal antibody that prevents the development of osteoclasts by inhibiting RANKL.

Question 19

Antibodies in sjogrens syndrome?

Answer 19

Rheumatoid factor
ANA
Anti Ro
Anti LA

Question 20

Which way does the lens dislocate in marfans syndrome?

Answer 20

Upward

Question 21

Risk factors for pseudogout

Answer 21

Haemochromatosis 
Hyperparathyroidism 
Low magnesium 
Low phosphate 
Acromegaly 
Wilsons disease

Question 22

Type of crystals in pseudogout

Answer 22

Calcium pyrophosphate

Weakly positive birefringent rhomboid shaped crystals

Question 23

What is sezary syndrome?

Answer 23

T cell cutaenous lymphoma 
Symptoms include itching, erythroderma of the palms, soles and face
Atypical T cells
Lymphadenopathy 
Hepatosplenomegaly

Question 24

Antibodies for diffuse cutaneous systemic sclerosis?

Answer 24

SCL 70 antibodies

Question 25

Most common cause of death in diffuse cutaneous systemic sclerosis?

Answer 25

Interstitial lung disease and pulmonary hypertension

Question 26

Antibodies for limited cutaneous systemic sclerosis?

Answer 26

Anti centromere

Question 27

Virus associated with polyarteritis nodosa

Answer 27

Hepatitis B

Question 28

What is necrobiosis lipoidica diabeticorum?

Answer 28

Shiny, painless areas of yellow/red skin on the shins or people with diabetes

Question 29

What is the triad of symptoms in bechets syndrome?

Answer 29

Oral ulcers, genital uclers and anterior uveitis

Question 30

What HLA type is associated with bechets syndrome?

Answer 30

HLA B51

Question 31

Antibodies associated with dermatomyositis?

Answer 31

Anti Mi 2

Question 32

Is microscopic polyangitis more associated with pANCA or c ANCA?

Answer 32

pANCA

Question 33

Antibodies associated with SLE?

Answer 33

``` ANA Rheumatoid factor (20%) ANti DsDNA (highly specific) Anti Smith (highly specific) Anti Ro and Anti La ```

Question 34

Drugs which worsen psoriasis?

Answer 34

Beta blockers, lithium, chlroquine, NSAIDS, ACE inhibitors, infliximab

Question 35

What is pagets disease?

Answer 35

A disease of increased bone turnover.

Question 36

Treatment for methotrexate toxicity?

Answer 36

Folinic acid

Question 37

What is the criteria for TNF inhibitors in rheumatoid arthritis?

Answer 37

Inadequate response to at least two DMARDs including methotrexate

Question 38

What is the most definitive diagnostic test for sjogrens syndrome?

Answer 38

Salivary gland biopsy

Question 39

What are the features of stills disease/

Answer 39

``` Arthralgia Elevated ferritin Pink maculopapular rash Pyrexia Lymphadenopathy RF and ANA negative ```

Question 40

Treatment for stills disease?

Answer 40

NSAIDs Steroids (may improve symptoms but don't improve prognosis) If persisting symptoms methotrexate, IL1 or anti TNF can be considered.

Question 41

Treatment for lichen planus?

Answer 41

Potent topical corticosteroids