Dermatopathology Chapter 7

Question 1

Multiple basaloid tumor micronodules fused together in jigsaw pattern, small ducts, and thick hyaline (pink) BMZ material surrounding each tumor micronodule?

Answer 1

Cylindroma

Question 2

Lymphocytes “peppered into tumor”?

Answer 2

Spiradenoma

Question 3

Nodule of monomorphous poroid cells with no epidermal connection?

Answer 3

Dermal duct tumor

Question 4

Erythema induratum (Bazin disease) is?

Answer 4

Subcutaneous inflammatory nodules with ulceration on posterior calves, Associated with past or active TB

Question 5

Verhoeff-van Gieson (VVG) stains elastic fibers and collagen?

Answer 5

Elastic fibers - Black
Collagen - Red
Rest of connective tissue - Yellow

Question 6

Masson Trichrome stains smooth muscle?

Answer 6

Smooth muscle - Red
Collagen fibers -Blue/green

Question 7

Movat’s pentachrome stains smooth muscle?

Answer 7

Smooth muscle - Red (Same as Masson trichrome)
Elastic fibers - Black
Collagen - Yellow

Question 8

Smooth muscle stains blue with what stain?

Answer 8

Phosphotungstic acid hematoxylin

Question 9

Lipids stain red with Oil-Red-O and Scarlet red part from?

Answer 9

Sudan black B, which stains lipid black

Question 10

What stain distinguishes iron/hemosidrin from melanin?

Answer 10

Prussian blue, stains iron, blue

Question 11

Von Kossa stains calcium?

Answer 11

Brown/black
and stains calcium red/orange with Alizarin red

Question 12

Congo red stains amyloid?

Answer 12

Red/pink, apple green birefringence when polarized

Question 13

Which stains are used for amyloid?

Answer 13

Thioflavin T and cresol violet

Question 14

Fontant masson and silver nitrate stain for?

Answer 14

Melanin

Question 15

Clear cell acanthoma and trichilemmoma show positive stain for?

Answer 15

PAS is positive due to increase glycogen in these conditions

Question 16

PAS-D for diastase is useful for?

Answer 16

Helpful for demonstrating BMZ thickening (lupus, DM) and thickened vessel walls of porphyria

Question 17

Giemsa stains?

Answer 17

Leishmania, Histoplasma, and Rickettsia

Question 18

What stain can you use for neurofibroma’s?

Answer 18

Bodian, stains positively black for nerve axons

Question 19

What stain would highlight elastic fiber changes in PXE?

Answer 19

Verhoefs-Van Gieson

Question 20

Most serious adverse event with clofazimine?

Answer 20

Crystal deposition in the bowel

Question 21

Granular layer contains?

Answer 21

Profillagrin

Question 22

Function of IL-1?

Answer 22

T-lymphocyte chemotaxis

Question 23

Weibel-Palade bodies are characteristic of?
A. Vascular endothelial cells
B. Keratinocytes
C. Langerhans cells
D. Melanocytes

Answer 23

A. Vascular endothelial cells

Question 24

Cellular blue nevus histo buzzword?

Answer 24

“dumb-bell configuration”

Question 25

Neurothecoma stains?

Answer 25

S100A6+, NKI-C3+, and PGP9.5+

Question 26

“copper pennies" or "Medlar bodies” within granulomatous dermal infiltrate are seen with?

Answer 26

Chromoblastomycosis

Question 27

Large spherules (up to 80 micro mm) containing smaller endospores?

Answer 27

Coccidioidomycosis

Question 28

Clear gelatinous capsule, mucicarmine+, surrounding yeast clusters seen with?

Answer 28

Cryptococcus

Question 29

Acantholytic dyskeratosis, corps ronds, corps grains seen in?

Answer 29

Darier disease

Question 30

Staining pattern for dermatofibroma?

Answer 30

Factor XIIIa+, stromelysin 3+, CD34- Opposite is true for Dermatofibrosarcoma is storiform pattern, extensive honeycombing of fat, factor XIIIa–, stromelysin 3–, CD34+

Question 31

Dermatomyositis has lots or less of mucin?

Answer 31

Abundant dermal mucin

Question 32

Tight (“coat-sleeve”) lymphocytic perivascular inflammation is histo seen in?

Answer 32

Erythema annulare centrifugum

Question 33

Glomus tumor stains positive for?

Answer 33

SMA+

Question 34

Granuloma faciale special histo?

Answer 34

Grenz zone; perivascular mixed inflammation (neutrophils, plasma cells, eosinophils)

Question 35

“satellite cell necrosis” feature of?

Answer 35

Acute GVHD

Question 36

“mulberry cells” (white vacuoles w pink borders)

Answer 36

Hibernoma

Question 37

Spindled myofibroblasts with characteristic perinuclear eosinophilic cytoplasmic inclusion bodies (PTAH+, trichrome+ , SMA+)

Answer 37

Infantile digital fibromatosis

Question 38

thin “sieve-like” vessels w/ hemorrhage and hemosiderin, conspicuous plasma cells

Answer 38

Kaposi sarcoma

Question 39

“sawtoothed rete,” seen with?

Answer 39

Lichen planus

Question 40

“pop bead-like”

Answer 40

Lobomycosis

Question 41

large CD30+ Reed-Sternberg-like cells

Answer 41

Lymphomatoid papulosis

Question 42

“Chicken wire” blood vessels in myxoid background?

Answer 42

Myxoid liposarcoma

Question 43

“buckshot” pattern, and transepidermal elimination of tumor cells; CK7+, CK20- seen in?

Answer 43

Paget's disease, extramammary PD

Question 44

“mariner’s wheel” seen in?

Answer 44

Paracoccidioidomycosis

Question 45

"ghost cells" seen with?

Answer 45

Pancreatic fat necrosis Pilomatricoma

Question 46

Multinucleated floret cells, “flower-like” arrangement of nuclei?

Answer 46

Pleomorphic lipoma

Question 47

PLEVA histo?

Answer 47

Parakeratosis Lichenoid interface Extravasated blood V-shaped (“wedge”) dermal lymphocytic infiltrate Acute epidermal changes, spongiosis +/– ulceration

Question 48

Answer 48

Dermatofibroma Interstitial spindle cell proliferation in “curlicue pattern,” collagen trapping, epidermal/follicular induction, hemosiderin-laden histiocytes/Touton-like GCs, Factor XIIIa+ and CD34-

Question 49

Dirty necrosis

Answer 49

Metastatic colon adenocarcinoma

Question 50

Anastomosing tumor islands with eccrine differentiation that demonstrate multiple foci of attachment to the epidermis.

Answer 50

Poroma

Question 51

Multiple nests of basaloid cells, some showing abortive hair follicle differentiation

Answer 51

Trichoepithelioma

Question 52

Sebaceous glands in cyst wall, eosinosphilic cuticle, “sharktooth” lining, represents?

Answer 52

Steatocytoma