Development of arteries Flashcards

(56 cards)

1
Q

قال إنما أشكو بثي وحزني إلي الله وأعلم من الله مالا تعلمون

A

فلما أن جاءه البشر ألقاه علي وجهه فارتد بصيرا قال ألم أقل لكم إني أعلم من الله مالاتعلمون

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2
Q

Asthma

A

◼ Asthma is a Heterogeneous disease characterized
by chronic airway inflammation.
◼ It is defined by the history of respiratory symptoms
such as wheeze, shortness of breath, chest
tightness, and cough, that vary overtime and in
intensity.
◼ Together with variable expiratory airflow limitation
(i.e. difficulty breathing air out of the lungs)

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3
Q

Type 2 Asthma ?

A
  • allergic

- aspirin exacerbated late onset eosiophilic ashtma

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4
Q

Non type 2 athma ?

A

Obesity
Pacugrenulocte mediated asthma smooth muscles medaiated
smoking mediated neutrophilic asthma

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5
Q

Factors that influence the risk of

asthma can be divided into:

A

• Host Factors: those that cause the development of
asthma
• Environmental Factors: those that trigger asthma
symptoms

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6
Q

How is asthma diagnosed?

A
Diagnosis should be based on:
I- History of Present illness
II- Past medical history
III- Family history
IV- Physical examination
V -Investigations
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7
Q

• Only hepatocytes and enterocytes
can effectively excrete cholesterol from
the body.

A

Some of the cholesterol in the intestine
is modified by bacteria before excretion,
giving rise to coprostanol (the major
sterol in stools)

All tissues especially liver, intestine, adrenal cortex, and reproductive
tissues.
• All the carbons provided by acetyl CoA
• It needs NADPH and ATP in the synthesis.
 Synthesis requires enzymes in both the cytosol and the
membrane of the smooth endoplasmic reticulum (ER)

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8
Q

indication of hydralazine artriolar VD

A
  1. HF: with nitrates but ACEI is better

2. Hypertension: IV in eclampsia

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9
Q

Mention the sets of aortic vessles ?

A

the aortic sac the dilated cranial part of TA truncus arteriosus it is
Ventral to pharynx

the 2 dorsal aortae passing dorsal to the primitve gut then unite caudally to form single dorsal aorta

the aortic arches 6 pairs connecting the dorasal aorta to the ventral aortic sac each pair runs in the coressponding pharyngeal archalong the side of pharynx

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10
Q

Arch or aorta is multiple source vessel ?

A

This due to its formation by the stem and left horn of the Aortic Sac
proximal part of the arch!

and middle fromt the left 4th arch

distal by the left dorsal aorta part between the 4th arch and the left 7th intersegmental artery

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11
Q

The bracicephalic artery source?> conitues as?>

A

The right horn of aortic sac and

contiues with the
right subclavian and
right common carotid artery

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12
Q

Dorsal aorta give intersgmental arterirs what are they ?

A

They are arterirs passing between somites to supply the body wall muscles and skin like thoracic wall edx: intercostal arteries

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13
Q

Dorsal aorta give lateral splanchnic arteris what are they ?

A

arteries supplying the intermediate cell mass mesoderm like urogenital system
like renal arteris

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14
Q

Dorsal aorta give ventral splanchmic arterirs what are they ?

A

arteries supplying the gut
1- the vitlline supplying the gut
2-umbilical function during ebryogensis after birth they are obliterated

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14
Q

Dorsal aorta give ventral splanchmic arterirs what are they ?

A

arteries supplying the gut
1- the vitlline supplying the gut
2-umbilical function during ebryogensis after birth they are obliterated

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15
Q

Vitlline arteries Remenatnts mention ?

A

supply yolk sac and gut
1- Coeliac Trunlk foregut
2-Superior Mesenteric artery midgut
3-inferior mesenteric artery hindgut

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16
Q

Umbilical artery connect ?

A

the placenta with develooping viscera

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17
Q

First and second origin of the Umbilical artery

A

1st dorsal aorta

2nd common iliac artey

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18
Q

fate of the umbilical artery ?>

A

the proximal part forms internal iliac artery

the distal part contiues as the umbilical artetry

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19
Q

External iliac source?:

A

its orginated as a bud from the common iliac artery

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20
Q

Dorsal aorta gives?

A

intersegmental
lateral splanchnic
visceral splanchnic

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21
Q

اكرام الضيف

A

عَن أَبِي هُرَيْرَةَ رضي الله عنه أَنَّ رَسُولَ اللهِ ﷺ قَالَ: (مَنْ كَانَ يُؤمِنُ بِاللهِ وَاليَوْمِ الآخِرِ فَلْيَقُلْ خَيْرَاً أَو لِيَصْمُتْ، وَمَنْ كَانَ يُؤمِنُ بِاللهِ وَاليَومِ الآخِرِ فَلْيُكْرِمْ جَارَهُ، ومَنْ كَانَ يُؤمِنُ بِاللهِ واليَومِ الآخِرِ فَلْيُكْرِمْ ضَيْفَهُ) رواه البخاري ومسلم.

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22
Q

سبب إجابة الدعاء

A

عَنْ أَبِيْ هُرَيْرَةَ رَضِيَ اللهُ تَعَالَى عَنْهُ قَالَ: قَالَ رَسُوْلُ اللهِ : (إِنَّ اللهَ تَعَالَى طَيِّبٌ لاَ يَقْبَلُ إِلاَّ طَيِّبَاً وَإِنَّ اللهَ أَمَرَ المُؤْمِنِيْنَ بِمَا أَمَرَ بِهِ المُرْسَلِيْنَ فَقَالَ : (يَا أَيُّهَا الرُّسُلُ كُلُوا مِنَ الطَّيِّبَاتِ وَاعْمَلُوا صَالِحاً) (المؤمنون: الآية51) ، وَقَالَ: (يَا أَيُّهَا الَّذِينَ آمَنُوا كُلُوا مِنْ طَيِّبَاتِ مَا رَزَقْنَاكُمْ ) (البقرة: الآية172) ثُمَّ ذَكَرَ الرَّجُلَ يُطِيْلُ السَّفَرَ أَشْعَثَ أَغْبَرَ، يَمُدُّ يَدَيْهِ إِلَى السَّمَاء،ِ يَا رَبِّ يَا رَبِّ، وَمَطْعَمُهُ حَرَامٌ ،وَمَشْرَبُهُ حَرَامٌ، وَغُذِيَ بِالحَرَامِ فَأَنَّى يُسْتَجَابُ لذلك) رواه مسلم.

23
Q

البعد عن مواطن الشبهات

A

عَنْ أَبِيْ عَبْدِ اللهِ النُّعْمَانِ بْنِ بِشِيْر رضي الله عنهما قَالَ: سَمِعْتُ رَسُوْلَ اللهِ ﷺ يَقُوْلُ: (إِنَّ الحَلالَ بَيِّنٌ وَإِنَّ الحَرَامَ بَيِّنٌ وَبَيْنَهُمَا أُمُوْرٌ مُشْتَبِهَات لاَ يَعْلَمُهُنَّ كَثِيْرٌ مِنَ النَّاس،ِ فَمَنِ اتَّقَى الشُّبُهَاتِ فَقَدِ اسْتَبْرأَ لِدِيْنِهِ وعِرْضِه، وَمَنْ وَقَعَ فِي الشُّبُهَاتِ وَقَعَ فِي الحَرَامِ كَالرَّاعِي يَرْعَى حَوْلَ الحِمَى يُوشِكُ أَنْ يَقَعَ فِيْهِ. أَلا وَإِنَّ لِكُلِّ مَلِكٍ حِمَىً . أَلا وَإِنَّ حِمَى اللهِ مَحَارِمُهُ، أَلا وإِنَّ فِي الجَسَدِ مُضْغَةً إِذَا صَلَحَتْ صَلَحَ الجَسَدُ كُلُّهُ وإذَا فَسَدَت فَسَدَ الجَسَدُ كُلُّهُ أَلا وَهيَ القَلْبُ) رواه البخاري ومسلم .

24
The 1st , 2nd , 3rd right distal of 6th arches diappear the firrst may not develop Remants of first arch of second arch
first arch give maxillary artery for head | second arch gives stapedial artery in the middle ear
25
The 3rd aortic arch gives\ procimally ? distally ?
proximal part gives the common carotid artery which give a bud for external carotid artety how formed ? distal part give the internal l carotid artery
26
external carotid artety how formed ?
the common carotid artery that arises proximal of 3rd arch gives the common carotid artery which give a bud for external carotid
27
the 4th arch gives?
Righ : Right subclavian artery | left : the middle aortic arch
28
the middle aortic arch arise from ?
the 4th arch LEFT
29
the right subclavain arise from
the 4th arch | and dorsal aorta between 4th arch and 7th intersegmental artery itself + brachiocepahilic
30
The 6th arch fate ?>
proximal gives right and left pulmonary artery ! distal left gives ductus arteriosus between left pulmonary and aortic arch right disappear
30
The 6th arch fate ?>
proximal gives right and left pulmonary artery ! distal left gives ductus arteriosus between left pulmonary and aortic arch right disappear
30
The 6th arch fate ?>
proximal gives right and left pulmonary artery ! distal left gives ductus arteriosus between left pulmonary and aortic arch right disappear
31
The arch that disappear completely?
the 5th arch
32
The part of dorsal aorta that disappear?>
the part between 3rd and 4th arches | between 7th intersegmental and the common dorsal aorta
33
aortic arches that remains
the 3d and 4th and 6th except distal right
34
Internal carotid is multiple source vessel ?.
Proximal and Distal !!!! the 3arch distal forms proximal internal carotid the part of dorsal aorta cranial to the 3rd arch forms the distal internal carotid
35
The right subclavian is mixed sourece artery ?
The proximal middle and distal proxiaml from the right 4th arch middle from the right part of the dorsal aorta between the right 4th arch and 7th intersegmental artery dorsal the right 7th intersegmental brachiocephalic
36
the arch of aorta is multisource artery?>
The proximal middle distal proimal form the ventral aortic sac stem and left horn middle from the left 4th arch distal from part of dorsal aorta between the left 4th aortic arch and left 7th intersegmental artery
37
What about left subclavian artery?
from the left 7th intersegmental artery
38
the right and left pulmonary arteris formed by ?
the proximal of 6th arch
39
the left pulmonary artery connected to the arch of aorta by ?
ductus arteriosius formed by distal left of 6th arch
40
Why the recurrent laryngeal nerve Left : in thorax right : in the neck ?
The left reucrrent laryngel nerve hooks around the 6th arch distal part which forms in the left the ductus arteriosus (ligamentum arterous later) so remain in the thorax and it asendes to larynx the right recuurent laryngeal cannot see the distal pare of 6th arch on right side is escaped !?> where are you ? so it try to hooks around the 5th arch but disappointedly , he didn't see him ! he also escaped with the 6th distal so it found a hand of cooperation when he saw the 4th arch which forms the subclavian artery it allowed him to hook around him and gives him a home in the neck
41
ألا أخبركم او احدثكم بشئ اذا نزل برجل منكم كرب او بلاء من بلاء الدنيا دعا به فرج عنه؟ بلي يا رسول الله!
دعاء ذي النون : لا إله إلا أنت سبحانك إني كنت من الظالمين توحيد العبودية والربوبية و التنزيه وكمال الصفات والتضرغ والخيفة و الخوف والرجاء والأمل ! عدم التوازن الضعف التعلق بالأسباب التعلق بالسماء لا بالأسباب التقوي بالله التوكل علي الله فلا يقدر عليه احد ! سبحانك ! لك الكمال إني كنت من الظالمين !!
42
The desncding aorta mention the sources >? o
proximal and distal proximal from the left dorsal aorta caudal to the left 7th intersegmental art distal from the single common dorsal aorta
43
Anomalies of arteries mention >? 4
``` 4 PCDR patent ductus arterosus coarction of aorta double aortic arch right aortic arch ```
44
Explain patent ductus arteriosus ,
The ductus arterosius is not converted into the ligamentum arteriosus make the way open for the deoxygenated blood to flow from the left pulmonary art to the arch of aorta may be 2ry to the coarctation of aorta
45
The aortic coarctation explain ?
it is narrowing of any segment aorta reducing blood flow to the lower body may be preductal and post ductal preductal with PDA Post ductal no PDA in case of postductal there will be good collateral circulation to desceding aorta wich gives the posterior intercostal anastomsing with anterorior inttercostal arssing fomr internal mamary artery the blood flow from ant to post to desscenfing aorta ok>? and the internal thoraci artery aslo shar in collateral cir
46
What are casuses of some notches in the ribs in radiograph of the thorax ?
some collateral vessesl of ant and post intercostal are large and tortuous and pulsating and this leads to erosin and notches ok ?
47
Explain the double aortic arch .
That is due to persisitant part of dorsal aorta between the right 7th intersegmental artery and the common dorsal aorta the 2 aortic arches areis from the ascending aorta and forms a ring around the trachea and esophagus then unites to form the descenging aorta
48
The right aortic arch explain >
This due to reverasl of the fates of 4 and 6 aortic arches the right of 4th will form the right arch aorta left form left subclavian and the right of 6th distal will form ductus artroius meanwhile the left distal disappear s
49
the caudal migration of heart casuining what to the recurrent laryngeal?
pulling it down and forimng a loop before it returns to the neck ?!
50
وتري الملائكة حافين من حول العرش يسبحون بحمد ربهم و قضي بينهم بالحق وقيل:
الحــــــــــــــــــــــــــــــمد لله رب العــــــــــــــــــــــــــــــــــــــــــــــــــــــــالميـــــــــــــــــــــــــــن
51
``` Has the patient had an attack or recurrent attacks of wheezing? Does the patient wheeze or cough after exercise? Does the patient experience symptoms after exposure to allergens or pollutants ``` Do the patient’s colds “go to the chest” or take >10 days to clear up? are symptoms treated by appropriate asthme treatment ? what is these steps?
history of patient
52
cholesterol synthesis steps mention
1.Synthesis of 3-hydroxy-3-methylglutaryl (HMG) CoA 2.Synthesis of mevalonic acid (mevalonate) 3.Conversion of mevalonate to activated isoprene unit (C5) .Condensation of 6 activated isoprene units to form squalene (C30 Conversion of squalene to lanosterol then to cholesterol (C27)
53
1.Synthesis of 3-hydroxy-3-methylglutaryl | (HMG) CoA show it?
Two acetyl CoA molecules condense to form acetoacetyl CoA by Thiolase enzyme. Next, a third molecule of acetyl CoA is added, producing Hydroxymethyl Glutaryl CoA (HMG CoA), a sixcarbon compound, this reaction is catalyzed by HMG CoA synthase.